Major depression, sleep, hostility and body mass index are associated with impaired quality of life in schizophrenia. Results from the FACE-SZ cohort.

Fond, Guillaume; Korchia, Théo; Verville, P L Sunhary de; Godin, O.; Schürhoff, Franck; Berna, Fabrice; Meynier, André; Aouizerate, Bruno; Capdevielle, Delphine; Chéreau, Isabelle; d’Amato, Thierry; Dubertret, Caroline; Dubreucq, Julien; Leignier, Sylvain; Mallet, J.; Misdrahi, D.; Passerieux, C.; Pignon, Baptiste; Rey, R.; Szöke, Andreı̈; Urbach, M.; Vidailhet, Pierre; Leboyer, Marion; Llorca, Pierre‐Michel; Lançon, Christophe; Boyer, Laurent

doi:10.1016/j.jad.2020.05.003

Cited by 12 publications

(12 citation statements)

References 57 publications

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“…This replicated finding is clinically significant, because it points to a window for maintaining the QoL as it provides a basis for clinicians to establish interventions for schizophrenia. Efforts should aim at improving patients' sleep problems using medications or cognitive behavioral therapy, thereby improving patients' QoL ( 55 ).…”

Section: Discussionmentioning

confidence: 99%

Quality of life in patients with schizophrenia: A 2-year cohort study in primary mental health care in rural China

Migliorini

Huang

et al. 2022

Front. Public Health

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ObjectiveQuality of life (QoL) has been always an important way to evaluate the outcomes of schizophrenia, but there have been few previous longitudinal studies and few in middle-income countries. This study aimed to explore the QoL in Chinese patients with schizophrenia treated in primary mental health care and the risk factors of QoL over time.MethodsPatients with schizophrenia treated in primary mental health care in rural/regional areas in Luoding, Guangdong, PR China, were evaluated with an extended questionnaire including the Chinese version of the World Health Organization Quality of Life (WHOQOL-BREF) at baseline and 2-year follow-up. Bivariate and multivariate analyses were conducted including Generalized Estimated Equation analyses (GEE).ResultsFour hundred and ninety-one patients with schizophrenia in primary care completed the 2-year follow up evaluation. The QoL physical, environmental, and social relationships domains showed improvement after the 2-year period, but the psychological domain did not. GEE results showed that earlier age of onset, older age, being employed, being unmarried, the thicker waist circumference, less use of clozapine or other SGAs, fewer hospitalizations, more frequent insomnia, more severe depressive and negative symptoms as well as worse treatment insight were independently associated with poor QoL in patients with schizophrenia.ConclusionAccording to our results, to improve the quality of life of patients with schizophrenia in primary care, we should pay more attention to the treatment of depression, negative and insomnia symptoms of schizophrenia, the choice and dosage of antipsychotic medication and improvement in the treatment compliance. The combined use of educational and behavioral strategies may improve treatment adherence.

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Section: Discussionmentioning

confidence: 99%

Quality of life in patients with schizophrenia: A 2-year cohort study in primary mental health care in rural China

Migliorini

Huang

et al. 2022

Front. Public Health

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“…Calligraphy activity may be particularly helpful for people with schizophrenia. This population experiences psychosis, including positive and negative symptoms, 7 and other health concerns, including cognitive impairments, 8 , 9 low QoL, 10 , 11 and emotional problems including depression, anxiety, and stress. 12 To build upon preliminary evidence of treatment effects of calligraphy activity for people with schizophrenia, 6 additional evidence using rigorous methods and large samples is needed.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of using calligraphic activity to treat people with schizophrenia: a randomized controlled trial in Southern Taiwan

Huang

Tsang

Wang

et al. 2022

Therapeutic Advances in Chronic Disease

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Background: Prior research has shown preliminary evidence that calligraphy activity improves various body functions and decreases severity of psychotic symptoms in individuals with schizophrenia. However, major limitations of earlier studies include small and heterogeneous samples. The current large-scale randomized controlled trial examined effects of calligraphy activity on cognition (including attention), emotions, psychotic symptoms, quality of life, and mood in people with schizophrenia. Methods: One-hundred-and-fifty patients with schizophrenia were randomly allocated to the treatment group (receiving calligraphy activity) or the control group (receiving general activity), both of which lasted for 24 weeks (70 minutes per session; one session per week). Assessments were conducted at pretest, posttest, and three-month follow-up. The Montreal Cognitive Assessment, Chu’s Attention Test, Depression, Anxiety, and Stress Scale, Positive and Negative Syndrome Scale, World Health Questionnaire on the Quality of Life-Brief Form, and Visual Analogue Scale were used. Results: Improved cognition and attention were found in both groups, although no group effects were shown. The treatment group appeared to show lower severity of positive symptoms at follow-up than posttest, whereas the control group appeared to show the opposite pattern. Improved mood was found in the treatment group. Conclusion: This study provides evidence regarding effects of calligraphy activity on increasing cognition and potentially decreasing severity of positive symptoms in patients with schizophrenia. Calligraphy activity can be incorporated in clinical occupational therapy and may be provided to supplement medication treatment. Trial Registration: ClinicalTrials.gov NCT03882619; https://clinicaltrials.gov/ct2/show/NCT03882619

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“…Modern medicine uses treatments based on synthetic molecules such as neuroleptics, anxiolytics, and antidepressants to treat neuropsychiatric diseases such as schizophrenia. Certainly, these treatments can exert some positive effects to decrease the degree of the severity of these disorders, but at the same time, they have important side effects which can be dangerous in certain cases [ 15 , 16 ]. Based on this fact, the present study comes to remedy these drawbacks and to frame the use of aromatic and medicinal plants for the treatment of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Carob Seed Peels Effect on Cognitive Impairment and Oxidative Stress Status in Methionine-Induced Mice Models of Schizophrenia

et al. 2022

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Ceratonia siliqua L. (Carob tree) is a Mediterranean evergreen, well known for its medicinal properties. The different parts of Carob were proven to exert antidiabetic, antibacterial, antifungal, and antiproliferative effects. Hence, the present paper aims to validate the positive correlation between the high antioxidant activity of carob seed peels and the improvement of negative symptoms of schizophrenia. Materials & Methods: The antioxidant activity was carried out using the β-carotene test. Methionine and carob seed peels (CSP) extracts (50 and 100 mg/kg) were orally administrated to mice for a week. After administration, behavioral tests were assessed using the Y-maze, elevated plus maze, and forced swimming tests, as well as the novel object recognition task. Furthermore, the oxidative stress status was evaluated by analyzing the levels of the antioxidant enzymes: Superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde levels (MDA). Results: Both extracts exhibited remarkable antioxidant activity and showed antibacterial effect against Gram-positive bacteria tested (Bacillus subtilis and Staphylococcus aureus) and against Pseudomonas aeruginosa (Gram-negative). Therefore, Escherichia coli was very resistant. The behavioral tests proved the efficacy of CSP in enhancing the cognitive impairment of animal models of schizophrenia. Hence, the stated correlation between oxidative stress and schizophrenia was confirmed by the increased SOD and GPx activities and the decreased MDA level. Conclusions: The present study gave further confirmation of the potential correlation between oxidative stress and the development of psychiatric disorders and highlighted the use of natural antioxidants, especially Ceratonia siliqua L. in the improvement of cognitive impairment in the dementia of schizophrenia.

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Major depression, sleep, hostility and body mass index are associated with impaired quality of life in schizophrenia. Results from the FACE-SZ cohort.

Cited by 12 publications

References 57 publications

Quality of life in patients with schizophrenia: A 2-year cohort study in primary mental health care in rural China

Quality of life in patients with schizophrenia: A 2-year cohort study in primary mental health care in rural China

Effectiveness of using calligraphic activity to treat people with schizophrenia: a randomized controlled trial in Southern Taiwan

Carob Seed Peels Effect on Cognitive Impairment and Oxidative Stress Status in Methionine-Induced Mice Models of Schizophrenia

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