Major depression disorder may have no causality on the atrial fibrillation risk: Evidence from the Mendelian randomization study
Feng Li,
Yan-Ni Wu,
Chi Geng
et al.
Abstract:Background:
Accumulated studies have indicated that depression was significantly associated with the atrial fibrillation (AF) risk. However, the causal effect of major depressive disorder (MDD) on the risk of AF was elusive.
Methods:
We performed a two-sample Mendelian randomization (MR) analysis using two genetic instrument tools for MDD to assess the potential causal effect of MDD on the AF risk, including a training dataset (37 single-nucleotide polymorphisms (SNPs) significantly associated with MDD) and … Show more
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