Major congenital anomalies in children born after frozen embryo transfer: a cohort study 1995-2006

Pelkonen, S.; Al, Hartikainen; Ritvanen, Annukka; Koivunen, Riitta; Martikainen, Hannu; Gissler, Mika; Tiitinen, Aila

doi:10.1093/humrep/deu088

Cited by 53 publications

(31 citation statements)

References 21 publications

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“…For the birth defects, our study did not indicate a significant difference between births after FET and births after fresh ET. The results from most previous studies are similar to this result, except for one study that found a higher risk for birth defects among births by FET (Belva et al 2008;Davies et al 2012;Pinborg et al 2013;Pelkonen et al 2014). In general, our result indicated that FET is a safe, convenient, effective method to use during ART treatment.…”

Section: Discussionsupporting

confidence: 89%

Comparative study on risk for birth defects among infants afterin vitrofertilization and intracytoplasmic sperm injection

Zhu

Wang

et al. 2018

Systems Biology in Reproductive Medicine

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Comparative study on risk for birth defects among infants after invitro fertilization and intracytoplasmic sperm injection, Systems Biology in Reproductive Medicine, 65:1, 54-60, ABSTRACTThis large retrospective study was conducted to compare the risk for birth defects among infants conceived by in vitro fertilization (IVF) with that among infants conceived by intracytoplasmic sperm injection (ICSI) and to explore the effect of frozen embryo transfer (FET) on the risk for birth defects among infants born by IVF and ICSI. All patients who received assisted reproductive technology (ART) treatment and who underwent childbirth during the period January 2005-August 2017 were included in this study. There were 18,221 births after ART included in the analysis; of these births, 12,649 were conceived by IVF, and 5,572 were conceived by ICSI. In the study, the prevalence of any birth defect in singleton infants was 1.15% with the use of IVF and 1.38% with the use of ICSI, and that in twin infants increased to 2.74% by IVF and 2.58% by ICSI. However, no significant difference between IVF and ICSI was found among all infants, singleton births or twin births. Additionally, in assessing ART infants born after FET, we did not detect a difference in the risk for birth defects between infants born by IVF and those born by ICSI. These results indicate that among the entire cohort of children conceived from ART and among the children conceived from FET, the risk for birth defects after ICSI is similar to that after IVF.

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Section: Discussionsupporting

confidence: 89%

Comparative study on risk for birth defects among infants afterin vitrofertilization and intracytoplasmic sperm injection

Zhu

Wang

et al. 2018

Systems Biology in Reproductive Medicine

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“…They concluded that singleton pregnancies following frozen versus fresh transfers were associated with better perinatal outcomes (antepartum hemorrhage RR 0.67, 95 % CI 0.55-0.81; preterm birth RR 0.84, 95 % CI 0.78-0.90; small for gestational age RR 0.45, 95 % CI 0.30-0.66; low-birth weight RR 0.69, 95 % CI 0.62-0.76; and perinatal mortality RR 0.68, 95 % CI 0.48-0.96) [45]. When comparing the risk of major congenital anomalies, no difference between the techniques was shown [46]. On the other hand, there is a report of an increased risk of macrosomia in singletons born after FET comparing with fresh embryo transfer [47].…”

Section: Discussionmentioning

confidence: 96%

Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

Rodriguez-Purata

Lee

Whitehouse

et al. 2016

J Assist Reprod Genet

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Purpose The aim of this study is to compare implantation and live birth rates (LBR) between fresh euploid embryo transfers versus cryo-all cycles with a subsequent embryo transfer into a prepared endometrium. Material and Methods This is a retrospective cohort study. Patients who underwent an IVF cycle with PGS with trophectoderm biopsy from January 2011 to July 2015 were included. Patients were divided into three groups: "Fresh Only," "Frozen Embryo Transfer ('FET) Only," and "Fresh ET then FET." For "Fresh Only" group (n = 345), PGS results were received within 24 h. For "FET Only" group (n = 514), results were expected after 24 h, and embryos were cryopreserved after biopsy; only FET was performed in this group (no fresh transfer). For "FET with a previous fresh ET" (n = 139) group, patients underwent a fresh ET with a subsequent FET, in which the same cohort of embryos was utilized. The main outcome measures were pregnancy rate (PR), clinical PR, implantation rate (IR), LBR, and early pregnancy loss rate. Results IRs were statistically higher in the "FET Only" group when compared to the "Fresh Only" group (59.5 vs. 50.6 %, p < 0.01) and the "FET with a previous fresh ET" (59.5 vs. 50.6 %, p < 0.05). LBR was statistically significant in the "FET Only" group when compared to the "Fresh Only" group (57.6 vs. 46.5 %, p < 0.005) but not when compared to "FET with a previous fresh ET" group (57.6 vs. 47.7 %, p = 0.07). Conclusions This analysis suggests euploid embryos to be more likely to implant and achieve a LBR in a synthetic FET cycle than in a fresh cycle.

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“…An increased risk of high birth weight and being large for gestational age (LGA, above 90th percentile) was reported as well [23][24][25][26][27][28][29]. A higher risk of congenital malformations for infants born after cryopreservation compared to fresh ET is also described [30,31]. When comparing children born after FET with natural conception, an increased risk for preterm birth, LBW, very LBW and need for caesarean sections was found [6].…”

Section: Introductionmentioning

confidence: 95%

Fresh and Frozen-Thawed Embryo Transfer Compared to Natural Conception: Differences in Perinatal Outcome

Spijkers

Lens

Schats

et al. 2017

Gynecol Obstet Invest

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Background/Aim: To compare the pregnancy outcome of singletons conceived after transfer of cryopreserved and thawed embryos (frozen embryo transfer [FET]) to singletons conceived after fresh embryo transfer (fresh ET) and natural conceived singletons. Methods: Using a retrospective data analysis on a study population consisting of 1,261 singletons born after FET and 2,519 singletons born after fresh ET between 2006 and 2015. The control group consisted of singletons born after natural conception. Main outcome measures consisted of birth weight (in grams), gestational age, preterm birth (<37 weeks of gestation), being large for gestational age (LGA, above 90th weight percentile adjusted for gestational age) and Apgar scores. Results: Babies born after FET had an increased risk of high birth weight (adjusted OR [AOR]) 2.92; 1.503-3.482) and being LGA (AOR fresh ET vs. FET 1.47; 1.210-1.787) compared to singletons born after fresh ET, as well as higher birth weights compared to natural conceived children. Conclusions: Singletons born after FET have a higher risk of high birth weight and being LGA compared to singletons after fresh ET and compared to natural conceived singletons. We assume that the freezing process might be the underlying cause.

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Major congenital anomalies in children born after frozen embryo transfer: a cohort study 1995-2006

Abstract: University Hospital of Oulu and Helsinki, Finland. THL covered the data linkages and the work of Annukka Ritvanen and Mika Gissler. There are no competing interests to be reported.

Cited by 53 publications

References 21 publications

Comparative study on risk for birth defects among infants afterin vitrofertilization and intracytoplasmic sperm injection

Comparative study on risk for birth defects among infants afterin vitrofertilization and intracytoplasmic sperm injection

Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

Fresh and Frozen-Thawed Embryo Transfer Compared to Natural Conception: Differences in Perinatal Outcome

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