Major component causing neurological toxicity in acute glufosinate ammonium poisoning: determination of glufosinate, 1-methoxy-2-propanol, and ammonia in serum and cerebrospinal fluid

Yeon, Seonghoon; Kim, Sung Hwa; Sim, Juhyun; Kim, Sunchun; Lee, Yoon-Suk; Kim, Hyun; Sung, Yong

doi:10.1080/15563650.2021.1952215

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…The mortality of GA poisoning patients was rarely reported in the literature. Neurotoxicity symptoms and central apnea requiring mechanical ventilation support were thought to be caused by hyperammonemia and hemodynamic toxicity [20]. Although previous study [21] have found signi cant correlations between ammonia levels in the serum and CSF and neurological complications, CSF ammonia detection was not available in our hospitals include our hospital.…”

Section: Discussionmentioning

confidence: 82%

Clinical features and prognostic factors of acute glufosinate ammonium

Huang

Xie

Shen

et al. 2023

Preprint

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This retrospective study was conducted on 67 patients who suffered from acute oral glufosinate ammonium poisoning to summarize a comprehensive overview of the clinical characteristics. General clinical data and laboratory test results were collected from the time of admission to hospital discharge. The most common clinical symptom of GA poisoning were nausea and vomiting, The incidence of unfavorable outcomes and the mortality of GA poisoning were 41.8% and 13.4%. The unfavorable outcomes group had a higher initial serum ammonia level (75.7±17.3umol/L vs 47.5±12.8umol/L), more ingestion amount of GA (103.6±63.4ml vs 72.3±37.7ml) and higher-level CK-MB (43.5 U/L vs 16.0 U/L) compared to favorable outcomes groups. The area under the curve in the ROC analysis for the predictive variables, initial ammonia and CK-MB, were 0.873 and 0.680.The patients with GA poisoning may exhibit clinical symptoms of gastrointestinal and neurological toxicity, as well as respiratory failure which experience different latent period that we need to pay special attention to. Initial serum and CK-MB might be the most accurate prognostic factors for predicting the unfavorable outcomes.

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Section: Discussionmentioning

confidence: 82%

Clinical features and prognostic factors of acute glufosinate ammonium

Huang

Xie

Shen

et al. 2023

Preprint

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“…Even though the blood ammonia concentration in patients with acute GAH poisoning may not accurately reflect the CNS ammonia level, it is necessary to monitor the plasma ammonia level from the ED admission (88,(97)(98)(99). This is because changes in plasma ammonia concentration can provide some estimation of the worsening or improvement of CNS toxicity symptoms in acute GAH poisoning (79,100). Therefore, it is believed that monitoring this can help assess the severity of patients with acute GAH poisoning regardless of the occurrence of CNS toxicity.…”

Section: Figure 4 Clinical Progress Of Acute Gah Poisoningmentioning

confidence: 99%

A Narrative Review of Contemporary Lethal Pesticides: Unveiling the Ongoing Threat of Pesticide Poisoning

Choi,

Kim,

Lim

2024

Clin Exp Emerg Med

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Following the 2011 ban on paraquat sales, South Korea has witnessed a significant reduction in the mortality rate associated with acute pesticide poisoning (1). Traditionally, paraquat and diquat, alongside several highly toxic organophosphates, carbamates, and organochlorine insecticides, have been recognized as culprits in causing fatalities among patients with acute pesticide poisoning (2,3).However, despite global efforts to curtail the use of these highly toxic pesticides, certain pesticides still exhibit a level of lethality surpassing their established clinical toxicity profiles (1-6). Understanding the clinical progression of these pesticides is paramount for physicians and toxicologists, as it holds the potential to enhance patient prognoses in cases of acute poisoning. This review aims to address the persistence of such highly lethal pesticides, which continue to pose a grave threat to victims of acute poisoning.

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