Major Coagulation Disturbances During Fractionated Plasma Separation and Adsorption

Meijers, Björn; Verhamme, Peter; Nevens, Frederik; Hoylaerts, Marc; Bammens, Bert; Wilmer, Alexander; Arnout, Jozef; Vanrenterghem, Yves; Evenepoel, Pieter

doi:10.1111/j.1600-6143.2007.01909.x

Cited by 67 publications

(38 citation statements)

References 15 publications

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“…[31,39] We observed no significant negative dynamics of serum albumin [oscillations: 32 (30-35) and 30 (26)(27)(28)(29)(30)(31)(32)(33)(34)(35) g/L, P = 0.052, before and after MARS-therapy; 33 (31-34) and 31 (28-36) g/L, P = 0.051, before and after Prometheus-therapy], which is probably due to the adequate routine correction of hypoproteinemia in patients with ALF. [39] Likewise, despite published data on the loss of coagulation factors during Prometheus-therapy, [40] we did not observe clinically significant hemorrhagic complications.…”

Section: Extracorporeal Blood Purification In Intensive Care Patientscontrasting

confidence: 54%

Blood purification in intensive care patients with multiple organ dysfunction syndrome and sepsis after cardiac surgery

Yaroustovsky¹,

Abramyan²,

Komardina³

et al. 2017

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How to cite this article: Yaroustovsky M, Abramyan M, Komardina E, Nazarova H. Blood purification in intensive care patients with multiple organ dysfunction syndrome and sepsis after cardiac surgery. Vessel Plus 2017;1:49-60.Extracorporeal blood purification is becoming increasingly important in intensive therapy for multiple organ dysfunction syndrome (MODS) and sepsis, considering all of their pathophysiological aspects. The results of treatment, particularly in children, considering their anatomical and physiological features, are related to the severity and progression of organ failure, the indications that are found, the choice of method, and the timely initiation of blood purification. Multiple organ support therapy is the aim of introducing and applying blood purification today. Various extracorporeal blood purification techniques directly affect the molecular and electrolyte composition of blood and influence all structures of the human body, which can allow us to correct, recover, replace and maintain homeostasis in MODS. The potential of new extracorporeal molecular technologies allows their successful use in severe cardiac and respiratory failure, acute kidney injury and hepatic dysfunction and in complex therapy for severe infections and sepsis and extreme metabolic violations. Adult and pediatric patients after cardiac surgery with cardiopulmonary bypass form a special cohort that often requires the application of various intra-and extracorporeal techniques due to the development of MODS, infections and sepsis in the postoperative period. Key words:Extracorporeal blood purification, acute kidney injury, acute liver failure, extracorporeal membrane oxygenation, sepsis, selective lipopolysaccharideadsorption, critical condition, cardiovascular surgery ABSTRACT Article history:

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Section: Extracorporeal Blood Purification In Intensive Care Patientscontrasting

confidence: 54%

Blood purification in intensive care patients with multiple organ dysfunction syndrome and sepsis after cardiac surgery

Yaroustovsky¹,

Abramyan²,

Komardina³

et al. 2017

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“…In the prometheus system, plasma is separated from the blood through a filter with pore size of 250 kDa, allowing the passage of large molecules. The consequent filtration and adsorption of clotting factors may cause coagulation disturbances (39). The nonselective removal of physiologically important molecules and the substantial plasma/albumin requirement limits the usefulness of artificial liver assist devices.…”

Section: Bridging Therapiesmentioning

confidence: 99%

Bridging Therapies and Liver Transplantation in Acute Liver Failure; 10 Years of MARS Experience from Finland

Kantola¹,

Ilmakunnas²,

Koivusalo³

et al. 2011

Scand J Surg

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acute liver failure is a life-threatening condition in the absence of liver transplantation option. the aetiology of liver failure is the most important factor determining the probability of native liver recovery and prognosis of the patient. extracorporeal liver assist devices like Mars (Molecular adsorbent recirculating system) may buy time for native liver recovery or serve as bridging therapy to liver transplantation, with reduced risk of cerebral complications. Mars treatment may alleviate hepatic encephalopathy even in patients with a completely necrotic liver. taking this into account, better prognostic markers than hepatic encephalopathy should be used to assess the need for liver transplantation in acute liver failure.

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“…In patients with advanced coagulation failure, an increased bleeding risk has been associated with MARS therapy [37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Molecular Adsorbents Recirculating System dialysis in children with cholestatic pruritus

et al. 2011

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Major Coagulation Disturbances During Fractionated Plasma Separation and Adsorption

Cited by 67 publications

References 15 publications

Blood purification in intensive care patients with multiple organ dysfunction syndrome and sepsis after cardiac surgery

Blood purification in intensive care patients with multiple organ dysfunction syndrome and sepsis after cardiac surgery

Bridging Therapies and Liver Transplantation in Acute Liver Failure; 10 Years of MARS Experience from Finland

Molecular Adsorbents Recirculating System dialysis in children with cholestatic pruritus

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