Major bioactive metabolites from marine fungi: A Review

Abstract

Biologists and chemists of the world have been attracted towards marine natural products for the last five decades. Approximately 16,000 marine natural products have been isolated from marine organisms which have been reported in approximately 6,800 publications, proving marine microorganisms to be a invaluable source for the production of novel antibiotic, anti tumor, and anti inflammatory agents. The marine fungi particularly those associated with marine alga, sponge, invertebrates, and sediments appear to be a rich source for secondary metabolites, possessing Antibiotic, antiviral, antifungal and antiyeast activities. Besides, a few growth stimulant properties which may be useful in studies on wound healing, carcinogenic properties, and in the study of cancers are reported. Recent investigations on marine filamentous fungi looking for biologically active secondary metabolites indicate the tremendous potential of them as a source of new medicines. The present study reviews about some important bioactive metabolites reported from marine fungal strains which are anti bacterial, anti tumour and anti inflammatory in action. It highlights the chemistry and biological activity of the major bioactive alkaloids, polyketides, terpenoids, isoprenoid and non-isoprenoid compounds, quinones, isolated from marine fungi.

Fungi associated with mesophotic macroalgae from the ‘Au‘au Channel, west Maui are differentiated by host and overlap terrestrial communities

“…Recent research shows that marine fungi contain a high diversity of putatively novel taxa (Comeau et al, 2016; Ishino et al, 2016; Picard, 2017), some of which may have medical applications (Hasan et al, 2015; Zin et al, 2016). Perhaps the best-described communities of reef-associated fungi are those growing on or in corals.…”

Quorum Sensing Inhibitors from the Sea Discovered Using Bacterial N-acyl-homoserine Lactone-Based Biosensors

“…Marine fungal strains are potent producers of polyketide-derived alkaloids, terpenes, peptides, and mixed biosynthesis compounds that represent chemical groups of secondary metabolites produced by fungi [79]. A fermentation broth of Penicillium sp.…”

Sponge-associated fungi from a mangrove habitat in Indonesia: species composition, antimicrobial activity, enzyme screening and bioactive profiling

“…Since the discovery of penicillin from fungi, substantial amounts of studies were devoted to the fungal bioactive compounds. Exploration of fungal metabolites is significantly increased after the scientists figured out that marine fungi, especially sponge-associated fungi, produce structurally unique bioactive compounds (Hasan et al 2015;Imhoff 2016). This fungal group produced certain potential bioactive compounds for pharmaceutical application such as citreorosein (anti-obesity activity, IC 50 = 0.17 lM), truncateol M (antiviral activity, IC 50 = 8.8 lM), misszrtine A (cytotoxic, IC 50 = 3.1 lM), and aspergillusene A (antibacterial activity, MIC = 4.3 lM) (Wang et al 2014;Zhao et al 2015;Noinart et al 2017;Zhou et al 2018).…”