Major and minor salivary gland tumors

Guzzo, Marco; Locati, Laura D.; Prott, Franz J.; Gatta, Gemma; McGurk, Mark; Licitra, Lisa

doi:10.1016/j.critrevonc.2009.10.004

Cited by 439 publications

(429 citation statements)

References 129 publications

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“…Some specific histopathological tumor types may have tendency towards specific sites but there is a general rule for salivary neoplasms: the smaller the salivary gland, the higher the rate of malignancy. Mainstay of treatment is surgery for all benign and malignant salivary gland neoplasms [1]. Tumor type, localization, and stage and grade of a malignant tumor may influence extent of a surgery.…”

Section: Introductionmentioning

confidence: 99%

Salivary Gland Tumors in Turkey: Demographic Features and Histopathological Distribution of 510 Patients

Kızıl

Aydíl

Ekinci

et al. 2012

Indian J Otolaryngol Head Neck Surg

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The aim of this study was to evaluate the demographic and clinicopathologic data of salivary gland tumors managed at a tertiary referral medical center in Turkey. The data of 510 patients with salivary gland tumors managed during the period of January 1984 to May 2012, were reviewed. Only primary neoplasms derived from salivary glands were included. Out of 510 neoplasms, 352 (69.0 %) were classified as benign and 158 (31.0 %) were classified as malignant. There was a male predominance and male:female ratio was 1.23 (281/229). The most common location was parotid gland (372/510, 72.9 %) followed by minor salivary glands (97/510, 19.0 %) and submandibular gland (40/510, 7.9 %). The malignancy rates were 21.5, 40.0, and 56.7 % in parotid, submandibular, and minor salivary glands locations, respectively. The most common location for minor salivary gland neoplasms was oral cavity (61/97, 62.9 %). Pleomorphic adenoma (PA) was the most common histopathological type (45.3 %) in the whole study group and also among pediatric patients. The most common malignant neoplasms were adenoid cystic carcinoma (39/510, 7.6 %) and mucoepidermoid carcinoma (5.7 %). Salivary gland tumors are more common in men. The malignancy rate is almost three times higher in neoplasms derived from minor glands when compared to parotid gland. PA is the most common histopathological tumor type in all locations and in all age groups.

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Section: Introductionmentioning

confidence: 99%

Salivary Gland Tumors in Turkey: Demographic Features and Histopathological Distribution of 510 Patients

Kızıl

Aydíl

Ekinci

et al. 2012

Indian J Otolaryngol Head Neck Surg

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“…But there is a clear exception in cases of high-grade and adenoid cystic histology [31]. Therefore, along with Guzzo et al, we recommend a follow-up period of 20 years in particular in adenoid cystic carcinomas or high-grade tumors including yearly chest X-rays.…”

Section: Prognosismentioning

confidence: 99%

Malignant minor salivary gland tumors: a retrospective study of 27 cases

Kruse

Grätz

Obwegeser

et al. 2010

Oral Maxillofac Surg

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Purpose Malignant tumors of the intra-oral minor salivary glands are uncommon. The aim of this study was to give information concerning the clinical features of these tumors, the distribution of location, treatment opportunities, and outcome. Methods Twenty-seven patients with malignant salivary gland tumors that were treated between January 1999 and December 2008 were evaluated retrospectively. Results Of the 27 minor salivary gland carcinomas, 48.1% were adenoid cystic carcinomas (ACC), 29.7% mucoepidermoid carcinomas (MEC), 22.2% adenocarcinomas (ADCA). The most common first symptom was a painless swelling in 60% of the cases, with the second most common symptom being ulcers (28%). Four recurrences and two metastases were found. No recurrence was observed in ADCA. All four patients experiencing a recurrence developed it in the first 3 years after treatment. Conclusion Wide excision with a clinical margin of 1 cm and in large tumors, positive surgical margins or perineural infiltration and postoperative radiotherapy (RT) can be recommended; but in order to give exact information concerning the possible benefit from postoperative RT, it needs large prospective multicenter studies. Long-term follow-up controls and in particularly longer than 5 years in ACC including yearly chest X-rays should be offered to these patients because of late metastasis and recurrences.

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“…The periodic returns are important especially in the first three years, since 70% of recurrences of minor salivary gland tumors occur in this period 4 . Follow-up visits should be scheduled periodically, according to the risk of disease recurrence and should be performed by head and neck surgeons or oncologists and dentists 14 . In this clinical case, the medical/dental follow-up over 10 years revealed no recurrences, metastases or other complications and, according to Gallego et al 12 , in cases of low-grade cystadenocarcinoma, which is the lesion described in this case, annual reviews for a 5-year period seem to be sufficient.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the form of treatment, according to the guidelines of the National Comprehensive Cancer Network (NCCN), the first-line treatment for carcinoma of major and minor salivary glands is surgical excision 14 which can be associated or not with radiation therapy 5 . In the case of low-grade cystadenocarcinoma, because of its indolent behavior and low malignant potential, local but complete excision appears to be sufficient 3 .…”

Section: Discussionmentioning

confidence: 99%

Papillary mucinous cystadenocarcinoma: rare malignant tumor in minor salivary gland

Mariano

Oliveira

Silva

et al. 2016

RGO, Rev. Gaúch. Odontol.

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RESUMODescrição do caso clínico de um cistadenocarcinoma papilar mucinoso, tumor maligno extremamente raro em glândula salivar e de difícil diagnóstico, em um paciente geriátrico. Paciente com 86 anos foi encaminhado para tratamento com lesão nodular na parte interna do lábio inferior do lado esquerdo estendendo-se para a mucosa jugal sem qualquer aspecto clínico de malignidade. A lesão era assintomática, apresentava consistência flácida e crescimento lento. Apesar das características clínicas favoráveis, após a remoção cirúrgica, o diagnóstico foi de cistadenocarcinoma papilar mucinoso. Entretanto, a atipia celular encontrada foi considerada leve e a reação imunohistoquímica para o Ki67 baixa, indicando uma baixa taxa de proliferação do tumor. A avaliação médica confirmou a ausência de transtornos sistêmicos e de metástases a distância. Apesar de se tratar de uma lesão maligna, devido ao baixo grau de proliferação do tumor e o acompanhamento cuidadosos realizado houve uma evolução favorável após o tratamento conservador após um período de acompanhamento de 11 anos e 6 meses.

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Major and minor salivary gland tumors

Cited by 439 publications

References 129 publications

Salivary Gland Tumors in Turkey: Demographic Features and Histopathological Distribution of 510 Patients

Salivary Gland Tumors in Turkey: Demographic Features and Histopathological Distribution of 510 Patients

Malignant minor salivary gland tumors: a retrospective study of 27 cases

Papillary mucinous cystadenocarcinoma: rare malignant tumor in minor salivary gland

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