Major advances in the development of ordered mesoporous materials

Szczęśniak, Barbara; Choma, J.; Jaroniec, Mietek

doi:10.1039/d0cc02840a

Cited by 91 publications

(48 citation statements)

References 174 publications

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“…Unlimited opportunities exist for the synthesis of MSNs in pure, doped, composite, and modified forms by employing different templates (soft and hard), conditions, and methods [74]. .…”

Section: Discovery Synthesis and Properties Of Msnsmentioning

confidence: 99%

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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Natural prodrugs derived from different natural origins (e.g., medicinal plants, microbes, animals) have a long history in traditional medicine. They exhibit a broad range of pharmacological activities, including anticancer effects in vitro and in vivo. They have potential as safe, cost-effective treatments with few side effects, but are lacking in solubility, bioavailability, specific targeting and have short half-lives. These are barriers to clinical application. Nanomedicine has the potential to offer solutions to circumvent these limitations and allow the use of natural pro-drugs in cancer therapy. Mesoporous silica nanoparticles (MSNs) of various morphology have attracted considerable attention in the search for targeted drug delivery systems. MSNs are characterized by chemical stability, easy synthesis and functionalization, large surface area, tunable pore sizes and volumes, good biocompatibility, controlled drug release under different conditions, and high drug-loading capacity, enabling multifunctional purposes. In vivo pre-clinical evaluations, a significant majority of results indicate the safety profile of MSNs if they are synthesized in an optimized way. Here, we present an overview of synthesis methods, possible surface functionalization, cellular uptake, biodistribution, toxicity, loading strategies, delivery designs with controlled release, and cancer targeting and discuss the future of anticancer nanotechnology-based natural prodrug delivery systems.

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“…Unlimited opportunities exist for the synthesis of MSNs in pure, doped, composite, and modified forms by employing different templates (soft and hard), conditions, and methods [74]. .…”

Section: Discovery Synthesis and Properties Of Msnsmentioning

confidence: 99%

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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“…Schematic illustration of major developments in the synthesis of OMMs. 4 The driving force for synthesizing porous oxides with ordered and/or uniform mesopores is the need of improving their catalytic/adsorption properties. For instance, ordered mesoporous channels in solids improve mass transfer and diffusion as well as expose active sites.…”

Section: Figmentioning

confidence: 99%

“…Nowadays, mesopores in solids are commonly created by using templating strategies. 4,[9][10][11][12][13] Hard templating involves the use of rigid templates (e.g., mesoporous silica, colloidal crystals, spherical nanoparticles), which need to be removed at the final step of the synthesis usually via dissolution with HF or NaOH solutions. This strategy is convenient and enables to obtain a large variety of mesoporous solids, but is time consuming, expensive and requires specific templates.…”

Section: Figmentioning

confidence: 99%

“…There are numerous reviews devoted to OMMs including mesoporous metal oxides, 4,7,8 e.g., our previous review providing an overview of all major groups of OMMs. 4 However, this field is continuously growing. Especially, mechanochemical synthesis of mesoporous metal oxides seems to be an emerging area with many potential applications of the resulting materials.…”

Section: Figmentioning

confidence: 99%

“…2,3 Since this discovery, extensive efforts have been made toward the synthesis of ordered mesoporous materials (OMMs) including silicas, organosilicas, metal oxides, carbons, zeolites, metal-and covalentorganic frameworks and almost countless two-or three-component composites based on these OMMs. 4 Major developments in the field of OMMs are presented in Fig. 1.…”

Section: Introductionmentioning

confidence: 99%

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Recent advances in mechanochemical synthesis of mesoporous metal oxides

2021

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Engineering the Coordination Environment of Single‐Rh‐Site with N and S Atoms for Efficient Methanol Carbonylation

Mu,

Long,

Song

et al. 2023

Adv Funct Materials

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The local coordination environment of central active sites plays a critical role in tuning the catalytic properties of heterogeneous single‐metal‐site catalysts (HSMSCs). However, carbon supports with inert surface properties provide weak interaction with the active sites, which hamper the effective modulation of the coordination structure of HSMSCs. Herein, this work shows that introducing N and S atoms into carbon support can modify the coordination environment of single‐Rh‐site and effectively improves the catalytic activity for the methanol carbonylation reaction. The synthesized Rh/AC‐NS with single‐Rh‐site exhibits a high methanol conversion of 88% and a stable acetyl production rate of 2812 h−1, in contrast with 1285 h−1 of Rh/AC without N‐ and S‐ functional groups, and meanwhile remarkably higher than those of Rh/AC‐N and Rh/AC‐S with only N‐ or S‐ functional group under the same mild reaction conditions. As revealed by the experimental result and density functional theory (DFT) calculations, the special combination of N‐ and S‐ functional groups offers favorable coordination configuration and also beneficial electronic structure for facilitated CH3I oxidative addition and CO insertion steps of single‐Rh‐site. This work offers new opportunities for rationally tuning the coordination structure of HSMSCs for heterogeneous catalysis.

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Major advances in the development of ordered mesoporous materials

Abstract: This feature article presents the main developments in the area of ordered mesoporous materials (OMMs) since their discovery in 1992, which is considered one of the milestones in the history of porous materials.

Cited by 91 publications

References 174 publications

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

Recent advances in mechanochemical synthesis of mesoporous metal oxides

Engineering the Coordination Environment of Single‐Rh‐Site with N and S Atoms for Efficient Methanol Carbonylation

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