Major achievements of evidence-based traditional Chinese medicine in treating major diseases

Chao, Jung; Dai, Yuntao; Verpoorte, Robert; Lam, Wing; Cheng, Yung‐Chi; Pao, Li-Heng; Zhang, Wei; Chen, Shilin

doi:10.1016/j.bcp.2017.06.123

Cited by 117 publications

(68 citation statements)

References 84 publications

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“…TCM has been shown to be an effective treatment for the relieve of complicated diseases in a multi-target/multi-component manner, which makes it unique among all traditional medicines [37]. Importantly, TCM has been used in the treatment of neurological diseases for over thousands of years.…”

Section: Discussionmentioning

confidence: 99%

“…The A. oxyphylla plant belongs to the Zingiber of Zingiberaceae genus, which is rich in terpenes, flavonoids, and diphenylpeptanes, among other compounds, which have been shown to have clinical activity in patients with diarrhea and enuresis [38][39][40][41]. Recently, a growing number of clinical trials and studies have shown that A. oxyphylla has a definite positive effect in ameliorating cognitive impairment and improving the characteristic pathological brain injuries in AD [26,37], although the underlying mechanism of action remains elusive. In addition, our previous results have shown that A. oxyphylla extracts have significant neuroprotective effects on reducing the paralysis ratio in AD transgenic C. elegans.…”

Section: Discussionmentioning

confidence: 99%

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Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer’s Disease

Wang

Guo

et al. 2020

IJMS

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Alpinia oxyphylla Miq. (i.e., A. oxyphylla), a traditional Chinese medicine, can exert neuroprotective effects in ameliorating mild cognitive impairment and improving the pathological hallmarks of Alzheimer's disease (AD). Here, 50 active compounds and 164 putative targets were collected and identified with 251 clinically tested AD-associated target proteins using network pharmacology approaches. Based on the Gene Ontology/Kyoto Encyclopedia of Genes and Genomes pathway enrichments, the compound-target-pathway-disease/protein-protein interaction network constructions, and the network topological analysis, we concluded that A. oxyphylla may have neuroprotective effects by regulating neurotransmitter function, as well as brain plasticity in neuronal networks. Moreover, closely-related AD proteins, including the amyloid-beta precursor protein, the estrogen receptor 1, acetylcholinesterase, and nitric oxide synthase 2, were selected as the bottleneck nodes of network for further verification by molecular docking. Our analytical results demonstrated that terpene, as the main compound of A. oxyphylla extract, exerts neuroprotective effects, providing new insights into the development of a natural therapy for the prevention and treatment of AD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer’s Disease

Wang

Guo

et al. 2020

IJMS

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“…The earliest Chinese herbalist texts, dating back to 168 B.C. mention dried leafs of Artemisia annua mixed with other plants prepared as an infusion used for treatment of haemorrhoids and as a libido enhancer (3)(4)(5).…”

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confidence: 99%

Anticancer Activity of Artemisinin and its Derivatives

Slezáková

Rudá-Kučerová

2017

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Artemisinin is an extract from the plant Artemisia annua. With its semi-synthetic derivatives, they form a group of well-known and efficacious antimalarial drugs. Recent studies have documented the potential anticancer effect of artemisinin and its derivatives (ARTs). This review summarizes results of preclinical studies, documenting mechanisms of anticancer actions of ARTs and clinical studies focused mainly on efficacy, safety and dose-ranging of ARTs as anticancer chemotherapeutics. The main mechanisms of action of ARTs is the production of reactive oxygen species, inhibition of cell cycle in G/G phase, induction of apoptosis and inhibition of angiogenesis. Safety studies have shown no evident toxicity and low incidence of adverse effects. ARTs potential to inhibit growth of solid tumours suggests their application in a neoadjuvant therapy. Dihydroartemisinin and artesunate exhibit chemosensitising effects in vivo in breast, lung, pancreas and glioma cancer cells, proposing the use of ARTs also in combination anticancer therapy.

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“…The clinical practice of traditional Chinese medicine (TCM) has a long history that has resulted in a considerable number of useful preparations, and TCM is still widely used today [5] [6]. Kanggan granule (KG) is a Chinese herbal compound that is included in the 2015 Chinese Pharmacopoeia for treating cold viruses.…”

Section: Introductionmentioning

confidence: 99%

Kanggan Granule Ameliorates Dexamethasone-Induced Immunosuppression in Mice

Gan¹,

Gu²,

Liu³

et al. 2019

JBM

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Objective: This study was to investigate the effect of the Chinese herbal compound Kanggan granule (KG) on immune function in a mouse model of immunosuppression and its possible mechanism of action. Method: ICR mice were randomly divided into a normal control group (untreated non-immunosuppressed, Control), untreated immunosuppressed group (Model), positive control group (immunosuppressed and treated with 1.6 g/kg astragalus granule [AG]), high-dose KG group (immunosuppressed and treated with 24 g/kg, KG-24), and low-dose KG group (immunosuppressed and treated with 6 g/kg, KG-6). Each group received intragastric administration once daily for 7 days. Immunosuppression was induced by an intraperitoneal injection of dexamethasone (25 mg/kg) once daily beginning on day 1 for 3 days. To illuminate the mechanism of immunomodulatory, we studied the effects of KG on nonspecific immunity, humoral immunity and cellular immunity in mice respectively. Results: KG improved organ weights and improved the phagocytic ability of mononuclear macrophages in immunosuppressed mice (p < 0.01 or p < 0.05). The proliferation of spleen lymphocytes and number of peripheral blood leukocytes were enhanced after KG treatment in immunosuppressed mice (p < 0.05). KG increased the CD4 + /CD8 + ratio in immunosuppressed mice (p < 0.01) and increased serum IL-2 and IgG levels (p < 0.01). Conclusions: KG can improve immune function in immunosuppressed mice. Nonspecific immunity, humoral immunity, and cellular immunity were all enhanced.

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Major achievements of evidence-based traditional Chinese medicine in treating major diseases

Cited by 117 publications

References 84 publications

Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer’s Disease

Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer’s Disease

Anticancer Activity of Artemisinin and its Derivatives

Kanggan Granule Ameliorates Dexamethasone-Induced Immunosuppression in Mice

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