Maitake Pro4X has anti‐cancer activity and prevents oncogenesis in <scp>BALB</scp>c mice

Roldan-Deamicis, Agustina; Alonso, Ernesto; Brie, Belén; Braico, Diego Aguilera; Balogh, Gabriela Andrea

doi:10.1002/cam4.744

Cited by 16 publications

(11 citation statements)

References 35 publications

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“…Not differences were found in the breast-tumour volume from BALBc mice treated with Maitake alone, either. These results are support by our recent findings [39], whether no significant reduction in the breast tumour volume were found after oral treatment during cancer prevention with Maitake Pro4X (5 mg/kg) of BALBc mice compare to the control untreated. However, histological studies of those breast tumours revealed that Maitake Pro4X treatment reduce the malignancy of the tumour, acquiring benign characteristics, such as be full of liquid inside, with net borders and with a small mitotic index.…”

Section: Discussionsupporting

confidence: 91%

Comparative Effect of Maitake Pro4x with Chemotherapy Breast Cancer Treatment

Braico¹,

Roldan-Deamicis²,

Brie³

et al. 2017

Biol Med (Aligarh)

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Background: Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells. For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system against the tumorigenesis process.

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Section: Discussionsupporting

confidence: 91%

Comparative Effect of Maitake Pro4x with Chemotherapy Breast Cancer Treatment

Braico¹,

Roldan-Deamicis²,

Brie³

et al. 2017

Biol Med (Aligarh)

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“…For our experiments, we have chosen five commercially available glucans (Table I). Glucan #1 is one of the most studied glucans (20), glucan #2 is an insoluble glucan isolated from algae, glucan #3 is Glucan Elite, an Agrobacterium-derived glucan (21), glucan #4 is a semisoluble oat-derived glucan, and glucan #5 is Maitake Gold isolated from mushrooms (22).…”

Section: Resultsmentioning

confidence: 99%

Anti-infectious and Anti-tumor Activities of β-glucans

Větvička

Větvičková

2020

Anticancer Res

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Background/Aim: The aim of this study was to directly compare the anti-infectious and anti-cancer effects of five commercially available glucans. Materials and Methods: We used five different glucans isolated from algae, yeast, bacteria, oat, and mushroom. We compared their effects on the stimulation of phagocytosis of blood cells, on the secretion of IL-2, and on the inhibition of melanoma and breast and lung cancers. In addition, we evaluated the effects of glucan supplementation on two experimental models of infection. Results: Most of the tested glucans stimulated phagocytosis and IL-2 secretion, reduced cancer growth, and ameliorated some effects of experimental infections. Conclusion: Glucans can produce significant pleiotropic effects, but the activity varies among individual samples.β-Glucans (hereafter called "glucans") are well-established natural immunomodulators with documented history of research reaching 60 years back, when a crude yeast extract was discovered to stimulate macrophages by complement activation (1). Glucans were found to be active throughout the animal kingdom and so far, no species has been found to be glucan resistant. Immunostimulating effects of glucans have been demonstrated in shrimp, fish (2), chicken (3), mice, rats, rabbits, goats, sheep, pigs (4), apes (5), and humans [for a review, see Vetvicka 2013 (6)]. Well-established biological effects of glucans include stimulation of immune reactions (7), control of diabetes (8), reduction of chronic fatigue syndrome (9), lowering of cholesterol levels (10, 11), and inhibition of cancer development (12).With numerous natural sources of glucans, including yeast, mushroom, bacteria, seaweed, and grain, it is not surprising that hundreds of structurally and functionally different glucans exist. However, despite the significant efforts of many laboratories, a direct link between structure and function remains elusive (13)(14)(15).Currently, more than 30,000 studies on the biological actions of glucans can be found in the peer-reviewed literature. However, there are still problems with results not being fully comparable, as dozens and most probably hundreds of glucans exist, most commercially available. With significant differences in source, purity, physicochemical characteristics, and solubility, it is often difficult to reach a conclusion regarding the general effects of glucans. The only viable solution is to perform direct comparative evaluations; hence, we endeavored to directly compare the anti-infectious and anti-cancer effects of five commercially available glucans.

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“…So far, we have demonstrated that the treatment with Maitake D-Fraction Pro4X prevents the development of mammary tumorigenesis, blocks tumor invasiveness, reduce tumor angiogenesis, increases overall survival in animals, and exhibits selective cytotoxicity [24][25][26]. Moreover, we also demonstrated that the use of Maitake D-Fraction Pro4X is safe and nontoxic as well.…”

Section: Introductionmentioning

confidence: 69%

Immunotherapeutic and Preventive Role of Purified Extract Rich in Beta-Glucans Derived from D-Fraction of Grifola frondosa Mushroom in Experimental Mice Biomodel of Mammary Carcinogenesis

Braico¹,

Máximo²,

Balogh³

2017

Breast Cancer - From Biology to Medicine

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The overall vision of the modern science needs to change to a revalorization of the natural compounds and their beneicial efects on human diseases, such as cancer. Medicinal mushrooms have been used since thousands of years due to its healing properties. Maitake (Grifola frondosa) is presented as one of the most interesting medicinal mushrooms that have been studied. Until now, Maitake D-Fraction may have anticarcinogenic activity, preventing oncogenesis and metastasis in certain tumor types. However, the exact molecular mechanism by which D-Fraction acts are yet unknown. The results shown in this chapter suggest that Maitake D-Fraction Pro4X, administered intraperitoneally, prevents signiicantly the development of mammary tumorigenesis, increases survival, and reduces the process of angiogenesis in BALBc mice. Although yet to determine the active component of the extract and the molecular mechanism by which it operates in the breast carcinogenesis process. The socioeconomic impact of this research project could be important, considering that in Argentina similar studies using natural compounds derived from medicinal mushrooms for cancer therapy have not yet been performed. The beneicial efects of Maitake, if proven, could be useful for the treatment of cancer patients who are undergoing chemotherapy or radiation or for breast cancer prevention in high-risk population.

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Maitake Pro4X has anti‐cancer activity and prevents oncogenesis in BALBc mice

Cited by 16 publications

References 35 publications

Comparative Effect of Maitake Pro4x with Chemotherapy Breast Cancer Treatment

Comparative Effect of Maitake Pro4x with Chemotherapy Breast Cancer Treatment

Anti-infectious and Anti-tumor Activities of β-glucans

Immunotherapeutic and Preventive Role of Purified Extract Rich in Beta-Glucans Derived from D-Fraction of Grifola frondosa Mushroom in Experimental Mice Biomodel of Mammary Carcinogenesis

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