Maitake Beta-Glucan Enhances the Therapeutic Effect of Trastuzumab <i>via</i> Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity
Yuki Masuda,
Shizuka Yamashita,
Yoshiaki Nakayama
et al.
Abstract:Trastuzumab, an anti-HER2 monoclonal antibody, is the mainstay treatment for of HER2-positive breast cancer. However, trastuzumab resistance is often observed during treatment. Therefore, new therapeutic strategies are needed to enhance the clinical benefits of trastuzumab. Maitake β-glucan MD-Fraction, isolated from Grifola frondosa, inhibits tumor growth by enhancing immune responses. In this study, we examined the effect of MD-Fraction on trastuzumab treatment of HER2-positive breast cancer. MD-Fraction did… Show more
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