Maintenance Therapy with Partially Hydrolyzed Guar Gum in the Conservative Treatment of Chronic Anal Fissure: Results of a Prospective, Randomized Study

Brillantino, Antonio; Iacobellis, Francesca; Izzo, Giuseppe; Martino, Natale Di; Grassi, Roberto; Renzi, Adolfo

doi:10.1155/2014/964942

Cited by 10 publications

(6 citation statements)

References 25 publications

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“…The goal of the treatment strategy is to decrease anal resting pressure in order to interrupt the vicious cycle of pain-spasm-ischemia involved in the arrest of fissure healing and self-maintenance of the disease [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Myoxinol (HydrolyzedHibiscus esculentusExtract) in the Cure of Chronic Anal Fissure: Early Clinical and Functional Outcomes

Renzi¹,

Brillantino

Sarno³

et al. 2015

Gastroenterology Research and Practice

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Objective. This study was designed to evaluate the early results of the topical application of Hydrolyzed Hibiscus esculentus Extract 3% ointment (Myoxinol 3%), a novel local product with Botox-like activity, in the conservative treatment of chronic anal fissure (CAF). Methods. Among all patients with CAF observed during the study period, 31 subjects met the inclusion criteria and underwent medical therapy with Myoxinol 3% ointment every 12 hours for 6 weeks. Two patients were lost to follow-up. Clinical and manometric follow-up was carried out eight weeks after treatment. Results. At follow-up the success rate was 72.4% (21/29); median VAS score and mean anal resting pressure were significantly lower if compared with respective baseline data. The only one adverse effect of the topical application of Myoxinol 3% ointment was perianal itch, which was reported by 3,4% (1/29) of the patients available for the analysis. However, in this case this symptom did not cause interruption of the treatment. Conclusions. The topical application of Myoxinol 3% ointment in the cure of CAF shows encouraging early results. Further researches with a larger series and a longer follow-up are needed to confirm these data.

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Section: Discussionmentioning

confidence: 99%

Myoxinol (HydrolyzedHibiscus esculentusExtract) in the Cure of Chronic Anal Fissure: Early Clinical and Functional Outcomes

Renzi¹,

Brillantino

Sarno³

et al. 2015

Gastroenterology Research and Practice

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“…According with a Cochrane meta-analysis of 18 randomized trials [ 48 ], with a multi-center double-blind placebo-controlled trial of 200 patients with chronic anal fissure [ 49 ] and with a systematic review [ 50 ], the treatment with topical nitroglycerine is associated with an healing rate of about 50%. Moreover, the treatment is limited by occurring of headache in at least 30% of patients, leading to cessation of therapy in up to 20% of them [ 50 – 52 ].…”

Section: Questions and Statementsmentioning

confidence: 99%

The Italian Unitary Society of Colon-proctology (SIUCP: Società Italiana Unitaria di Colonproctologia) guidelines for the management of anal fissure

Brillantino,

Renzi,

Talento

et al. 2023

BMC Surg

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Introduction The aim of these evidence-based guidelines is to present a consensus position from members of the Italian Unitary Society of Colon-Proctology (SIUCP: Società Italiana Unitaria di Colon-Proctologia) on the diagnosis and management of anal fissure, with the purpose to guide every physician in the choice of the best treatment option, according with the available literature. Methods A panel of experts was designed and charged by the Board of the SIUCP to develop key-questions on the main topics covering the management of anal fissure and to performe an accurate search on each topic in different databanks, in order to provide evidence-based answers to the questions and to summarize them in statements. All the clinical questions were discussed by the expert panel in different rounds through the Delphi approach and, for each statement, a consensus among the experts was reached. The questions were created according to the PICO criteria, and the statements developed adopting the GRADE methodology. Conclusions In patients with acute anal fissure the medical therapy with dietary and behavioral norms is indicated. In the chronic phase of disease, the conservative treatment with topical 0.3% nifedipine plus 1.5% lidocaine or nitrates may represent the first-line therapy, eventually associated with ointments with film-forming, anti-inflammatory and healing properties such as Propionibacterium extract gel. In case of first-line treatment failure, the surgical strategy (internal sphincterotomy or fissurectomy with flap), may be guided by the clinical findings, eventually supported by endoanal ultrasound and anal manometry.

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“…The application of functional oligosaccharides in food has penetrated various fields. As a functional health food, it plays an important role in human health (Brillantino et al, 2014). The main role of oligosaccharides in feed is to inhibit the colonization of pathogens, promote the proliferation of beneficial bacteria, protect the intestinal health of animals, enhance immunity, and reduce the production of harmful gases such as ammonia in feces.…”

Section: Application Of Oligosaccharidesmentioning

confidence: 99%

Research status of the effects of natural oligosaccharides on glucose metabolism

Zhang

Chen

et al. 2022

eFood

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Diabetes is a common and frequently occurring endocrine and metabolic disease characterized by hyperglycemia with genetic tendency. At present, the drugs for diabetes include metformin, glimepiride, and acarbose. Although these drugs are effective, long‐term usage will produce secondary symptoms, such as Cushing's syndrome, limb hypertrophy, and even the risk of hypoglycemia. Many natural products have been found to treat diabetes, among which oligosaccharides are the most valuable. Oligosaccharides are low‐level oligosaccharides formed by the linkage of 2–10 monosaccharides through glycosidic bonds. Common oligosaccharides include chitosan oligosaccharides, xylooligosaccharides, konjac glucomannan, and brown algae oligosaccharides. It has the effects of reducing blood glucose, blood pressure, antioxidant, anti‐inflammatory, immune regulation, antiallergy, promoting the growth of bifidobacteria, and improving body health. With the continuous exploration of the medicinal value of natural oligosaccharides, more and more attention has been paid to their research. This review introduces some representative oligosaccharides with hypoglycemic effects, including their structural characteristics and hypoglycemic mechanism, as well as the application status and future development trend of oligosaccharides.

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Maintenance Therapy with Partially Hydrolyzed Guar Gum in the Conservative Treatment of Chronic Anal Fissure: Results of a Prospective, Randomized Study

Cited by 10 publications

References 25 publications

Myoxinol (HydrolyzedHibiscus esculentusExtract) in the Cure of Chronic Anal Fissure: Early Clinical and Functional Outcomes

Myoxinol (HydrolyzedHibiscus esculentusExtract) in the Cure of Chronic Anal Fissure: Early Clinical and Functional Outcomes

The Italian Unitary Society of Colon-proctology (SIUCP: Società Italiana Unitaria di Colonproctologia) guidelines for the management of anal fissure

Research status of the effects of natural oligosaccharides on glucose metabolism

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