Maintenance therapy simplification using a single daily dose: A preliminary real-life feasibility study in patients with Wilson disease

Wilson Disease and Alpha1-Antitrypsin Deficiency: A Review of Non-Invasive Diagnostic Tests

“…Expressed as the percentage of total serum copper, relative exchangeable copper (REC) is a valuable diagnostic test with a high sensitivity and specificity. With a cut-off of 18.5%, REC was able to discriminate WD patients from heterozygous ATP7B carriers, healthy controls and patients with other liver diseases [45,47,48,51]. CuEXC has also shown interesting results to monitor treatment response in animal models and WD patients, but an optimal cut-off has yet to be defined [46,48].…”