Maintenance of the Corpus Luteum and Physiologic Actions of Progesterone

Bradbury, James T.; Brown, Willis E.; Gray, Laman A.

doi:10.1016/b978-0-12-571105-0.50009-5

Cited by 34 publications

(31 citation statements)

References 67 publications

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“…Apart from a variable extension of the cycle during which the operation is performed, hysterectomy is without effect on the oestrous cycle (Long & Evans, 1922;Bradbury, Brown & Gray, 1950). Similarly, neither posterior uterine section (O'Shea, 1971), nor ligation of the uterus leading to accumulation of fluid in the lumen (Perrine, 1967), affect the duration of subsequent oestrous cycles.…”

Section: Discussionmentioning

confidence: 99%

Observations on the Mechanism of Prolongation of Pseudopregnancy in the Rat Following Transection of the Uterine Horns

Jd¹

1971

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Summary. Transection of the uterine horns near to their cervical ends (posterior uterine section) led to a prolongation of pseudopregnancy from 13\m=.\1\m=+-\0\m=.\16 (control) to 14\m=.\9\ m=+-\ 0\m=.\24 days (P<0\m=.\001). This was significantly greater than the prolongation following transection of the uterine horns one third of the way from the uterotubal junction to the uterine bifurcation (14\m=.\0 \ m=+-\ 0\m=.\16 days, P<0\m=.\01).When unilateral ovariectomy was accompanied by contralateral posterior uterine section, the prolongation of pseudopregnancy ( 14\ m=. \ 5\ m=+-\ 0\m=.\20 days, control 12\m=.\8\ m=+-\ 0\m=.\25 days, P< 0\m=.\001) was greater than when accompanied by ipsilateral posterior uterine section (13\m=.\7 \ m=+-\ 0\m=.\20days, P<0\m=.\02).These results indicate a quantitative and a unilateral component in the effects of uterine section, and support the hypothesis that prolongation of pseudopregnancy following posterior uterine section is brought about by the same mechanism as that following hysterectomy.

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Section: Discussionmentioning

confidence: 99%

Observations on the Mechanism of Prolongation of Pseudopregnancy in the Rat Following Transection of the Uterine Horns

Jd¹

1971

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“…To account for these changes, he suggested that the uterus (endome¬ trium) produced an internal secretion that controlled the life-span of the corpus luteum, but his attempts to demonstrate this in hysterectomized guinea-pigs with transplanted uterine tissue were unsuccessful. The transplanted tissue was susceptible to the formation of placentomata which, as was suggested by Bradbury, Brown & Gray (1950), could have interfered with normal uterine function and prevented the tissue from exerting a replacement effect, i.e. causing regression of the corpora lutea.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hysterectomy at Different Stages in the Life Cycle of the Corpus Luteum in the Guinea-Pig

Rowlands¹

1961

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Summary. Hysterectomy on the 5th day of the luteal phase inhibited the dioestrous cycle for at least 8 months. The corpora lutea persisted throughout this period and, at the end, contained an appreciable amount of progesterone.Hysterectomy on the 10th day of the luteal phase caused the corpora lutea to enlarge as in pregnancy and to persist for a period about equal to that of gestation.Hysterectomy on the 15th day of the luteal phase prevented the impending ovulation and oestrus in 70 % (24/35) of animals. In these, the major effect was the arrest of the regressive changes in the corpora lutea, which became only slightly enlarged. In the remaining animals, ovulation and oestrus occurred shortly after the operation. The regres¬ sion of the corpora lutea occurred normally but the corpora lutea that formed post-operatively responded in the same way as those in animals operated on the 5th or 10th days of the luteal phase. The nature of the stimulus of hysterectomy on the corpus luteum of the guinea-pig is discussed briefly.

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“…In vivo, administration of hCG can increase the amount and duration of progesterone secretion (Hanson et al, 1971). However, the menstrual cycle is rarely prolonged for more than 2 weeks despite continued administration of hCG (Bradbury et al, 1950). In addition, corpus luteum function wanes and the luteal-placental shift occurs when maternal hCG reaches its peak, i.e.…”

Section: Biological Propertiesmentioning

confidence: 99%