Maintenance of response to dupilumab in prurigo nodularis: A retrospective cohort study

Selvaraj, Katina J; Stewart, T. D.; Frew, John W.

doi:10.1016/j.jdin.2023.02.006

JAAD International

2023

DOI: 10.1016/j.jdin.2023.02.006

|View full text |Cite

Maintenance of response to dupilumab in prurigo nodularis: A retrospective cohort study

Katina J Selvaraj

T. D. Stewart

John W. Frew

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

(1 citation statement)

References 4 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, rates of skin lesion resolution, complete or nearly complete, were observed in up to 48% of patients after undergoing 24 weeks of treatment [170]. Furthermore, anecdotal evidence suggests that off-label use of dupilumab has demonstrated favorable efficacy and safety profiles in pediatric and adolescent PN patients [171][172][173]. However, dupilumab took longer to alleviate pruritus in atopic PN compared to nonatopic PN patients [174].…”

mentioning

confidence: 99%

Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics

Yook,

Lee

2024

IJMS

View full text Add to dashboard Cite

Chronic pruritus that lasts for over 6 weeks can present in various forms, like papules, nodules, and plaque types, with prurigo nodularis (PN) being the most prevalent. The pathogenesis of PN involves the dysregulation of immune cell–neural circuits and is associated with peripheral neuropathies, possibly due to chronic scratching. PN is a persistent and challenging condition, involving complex interactions among the skin, immune system, and nervous system. Lesional skin in PN exhibits the infiltration of diverse immune cells like T cells, eosinophils, macrophages, and mast cells, leading to the release of inflammatory cytokines and itch-inducing substances. Activated sensory nerve fibers aggravate pruritus by releasing neurotransmitters, perpetuating a vicious cycle of itching and scratching. Traditional treatments often fail, but recent advancements in understanding the inflammatory and itch transmission mechanisms of PN have paved the way for innovative therapeutic approaches, which are explored in this review.

show abstract

mentioning

confidence: 99%

Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics

Yook,

Lee

2024

IJMS

View full text Add to dashboard Cite

show abstract

A critical review of dupilumab for adult patients with prurigo nodularis

Biazus Soares,

Yosipovitch

2023

Expert Review of Clinical Immunology

View full text Add to dashboard Cite

Molecular mechanisms of pruritus in prurigo nodularis

Shao,

Wang,

Zhu

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Pruritus is the most common symptom of dermatological disorders, and prurigo nodularis (PN) is notorious for intractable and severe itching. Conventional treatments often yield disappointing outcomes, significantly affecting patients’ quality of life and psychological well-being. The pathogenesis of PN is associated with a self-sustained “itch-scratch” vicious cycle. Recent investigations of PN-related itch have partially revealed the intricate interactions within the cutaneous neuroimmune network; however, the underlying mechanism remains undetermined. Itch mediators play a key role in pruritus amplification in PN and understanding their action mechanism will undoubtedly lead to the development of novel targeted antipruritic agents. In this review, we describe a series of pruritogens and receptors involved in mediating itching in PN, including cytokines, neuropeptides, extracellular matrix proteins, vasculogenic substances, ion channels, and intracellular signaling pathways. Moreover, we provide a prospective outlook on potential therapies based on existing findings.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Maintenance of response to dupilumab in prurigo nodularis: A retrospective cohort study

Cited by 3 publications

References 4 publications

Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics

Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics

A critical review of dupilumab for adult patients with prurigo nodularis

Molecular mechanisms of pruritus in prurigo nodularis

Contact Info

Product

Resources

About