Maintenance of discrete somatosensory maps in subcortical relay nuclei is dependent on an intact sensory cortex

Erzurumlu, Reha S.; Ebner, FF

doi:10.1016/0165-3806(88)90229-5

Cited by 22 publications

(7 citation statements)

References 30 publications

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“…A perinatal loss of corticobulbar projections has been shown to prevent the development of segmented metabolic activity within the brainstem (Chiaia et al, 1991; Erzurumlu and Ebner. 1988).…”

Section: Discussionmentioning

confidence: 99%

Neurotrophin receptor (p75) in the trigeminal thalamus of the rat: Development, response to injury, transient vibrissa-related patterning, and retrograde transport

2000

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Section: Discussionmentioning

confidence: 99%

Neurotrophin receptor (p75) in the trigeminal thalamus of the rat: Development, response to injury, transient vibrissa-related patterning, and retrograde transport

2000

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“…Barrelettes — each of which corresponds to a single whisker and sinus hair on the ipsilateral side of the face — are present in the PrV and in two of the three subnuclei of the SpV, interpolaris and caudalis. Of these nuclei, it is the PrV that transmits the patterned face map template to the contralateral thalamus and subsequently the somatosensory barrel cortex 66,67 . The ascending branches of the trigeminal tract axons convey the face map to the PrV and the descending branches to the SpV subnuclei.…”

Section: Face Map Patterning In the Brainstemmentioning

confidence: 99%

Mapping the face in the somatosensory brainstem

2010

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The facial somatosensory map in the cortex is derived from facial representations that are first established at the brainstem level and then serially ‘copied’ at each stage of the somatosensory pathway. Recent studies have provided insights into the molecular mechanisms involved in the development of somatotopic maps of the face and whiskers in the trigeminal nuclei of the mouse brainstem. This work has revealed that early molecular regionalization and positional patterning of trigeminal ganglion and brainstem target neurons are established by homeodomain transcription factors, the expression of which is induced and maintained by signals from the brain and face. Such position-dependent information is fundamental in transforming the early spatial layout of sensory receptors into a topographic connectivity map that is conferred to higher brain levels.

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“…Prior anatomical, electrophysiological, and neonatal whisker follicle or infraorbital nerve lesion studies (Belford and Killackey, 1979a,b;Hayashi, 1980Hayashi, , 1985Arvidsson, 1982;Bates et at., 1982;Jacquin and Rhoades, 1983, 1985Jacquin et at., 1984Jacquin et at., , 1986bJacquin et at., ,c, 1988aJacquin et at., ,b, 1989aJacquin et at., ,b, 1992Jacquin et at., , 1993Durham and Woolsey, 1984;Ma and Woolsey, 1984;Bates and Killackey, 1985;Nomura et at., 1986;Renehan et at., 1986;Chiaia et at., 1987aChiaia et at., ,b, 1991Chiaia et at., , 1992bYip et at., 1987;Erzurumlu and Ebner, 1988;Arvidsson and Rice, 1991;Waite and de Permentier, 1991;Bennett-Clarke et at., 1992;Henderson et at., 1992bHenderson et at., , 1993 suggest that the central projections of single whiskers are organized into longitudinally oriented columns that are somatotopically parcellated in the transverse plane in at least three of the four V brain-stem subnuclei.…”

Section: Trigeminal Patterns and Circuits: Adulthoodmentioning

confidence: 99%