Maintenance of brain thyroid hormone level during peripheral hypothyroid condition in adult rat

Kundu, Samita; Pramanik, Mitali; Roy, Sumedha; De, Jhuma; Biswas, Angshuman; Ray, Arun Kumar

doi:10.1016/j.lfs.2006.04.006

Cited by 42 publications

(58 citation statements)

References 29 publications

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“…expression after pharmacological suppression of TH occur at a much slower timescale, consistent with the known TH homeostasis capability of central neural tissue, which maintains physiological levels of T3 for some time, even under conditions of peripheral hypothyroidism (Kundu et al, 2006), and consistent with our observation that changes in the expression pattern of S-and M-cone opsin were first detectable 5-7 weeks after serum TH concentrations had decreased to hypothyroid levels.…”

Section: Discussionsupporting

confidence: 90%

Thyroid Hormone Controls Cone Opsin Expression in the Retina of Adult Rodents

Glaschke¹,

Weiland²,

Turco³

et al. 2011

J. Neurosci.

103

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Mammalian retinas display an astonishing diversity in the spatial arrangement of their spectral cone photoreceptors, probably in adaptation to different visual environments. Opsin expression patterns like the dorsoventral gradients of short-wave-sensitive (S) and middle-to long-wave-sensitive (M) cone opsin found in many species are established early in development and thought to be stable thereafter throughout life. In mouse early development, thyroid hormone (TH), through its receptor TR␤2, is an important regulator of cone spectral identity. However, the role of TH in the maintenance of the mature cone photoreceptor pattern is unclear. We here show that TH also controls adult cone opsin expression. Methimazole-induced suppression of serum TH in adult mice and rats yielded no changes in cone numbers but reversibly altered cone patterns by activating the expression of S-cone opsin and repressing the expression of M-cone opsin. Furthermore, treatment of athyroid Pax8 Ϫ/Ϫ mice with TH restored a wild-type pattern of cone opsin expression that reverted back to the mutant S-opsin-dominated pattern after termination of treatment. No evidence for cone death or the generation of new cones from retinal progenitors was found in retinas that shifted opsin expression patterns. Together, this suggests that opsin expression in terminally differentiated mammalian cones remains subject to control by TH, a finding that is in contradiction to previous work and challenges the current view that opsin identity in mature mammalian cones is fixed by permanent gene silencing.

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Section: Discussionsupporting

confidence: 90%

Thyroid Hormone Controls Cone Opsin Expression in the Retina of Adult Rodents

Glaschke¹,

Weiland²,

Turco³

et al. 2011

J. Neurosci.

103

View full text Add to dashboard Cite

show abstract

“…Thyroid hormones are involved in the regulation of numerous body functions including lipid and carbohydrate metabolism, oxygen consumption and several physiological functions such as development, reproduction and growth (Kundu et al, 2006). Alterations in their normal levels cause some biochemical and clinical abnormalities such as hypothyroidism.…”

Section: Introductionmentioning

confidence: 99%

Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)

Kumar¹

2013

IOSR-JPBS

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“…either singly or in combination with PTU (6n-propyl-2-thiouracil, Sigma Chemical Co., USA) at a dose of 2 mg/100 g b.w. for two consecutive days (Days '0' and '1') and sacrificed on Day '2' or the day of onset of 'central thyroid hormone homeostasis' [6]. Similarly they were injected with dopaminergic receptor antagonist haloperidol (HALO, Sigma Chemical Co., USA) at a dose of 0.1 mg/kg b.w.…”

Section: Animals and Treatmentmentioning

confidence: 99%

“…Infact, animal studies have shown that antidepressants affect deiodinase activities and T3/T4 concentrations in rat brain [5]. Nothing is known about the effect of dopamine (DA) in maintenance of cerebral TH levels effecting to 'central thyroid hormone homeostasis' during peripheral hypothyroidism [6].…”

Section: Introductionmentioning

confidence: 99%

Possible Influence of Dopaminergic Receptor in Maintenance of Thyroid Hormone Homeostasis: A Study in Adult Rat Brain

Kundu

2012

J Endocrinol Metab

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Background: The role of thyroid hormone (TH) disbalance in genesis of psychological disturbances in the adult humans is well known. A phenomenon of 'central thyroid hormone homeostasis' characterized by increased synaptosomal T3 content, deiodinase type II (DII) activity and cAMP level, is known to exist during peripheral hypothyroidism. This phenomenon tries to counteract the adverse psychobehavioural manifestations commonly associated with TH deficiency. A close physiological association between sympathetic nervous system activity and TH is well known. Dopamine, a predominant catecholamine neurotransmitter in the mammalian brain, controls a variety of functions including locomotion, cognition, emotion and also affects neuroendocrine secretion. In the present study relationship between TH and dopamine has been presumed to be involved in the maintenance of 'central thyroid hormone homeostasis' in adult rat.

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Maintenance of brain thyroid hormone level during peripheral hypothyroid condition in adult rat

Cited by 42 publications

References 29 publications

Thyroid Hormone Controls Cone Opsin Expression in the Retina of Adult Rodents

Thyroid Hormone Controls Cone Opsin Expression in the Retina of Adult Rodents

Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)

Possible Influence of Dopaminergic Receptor in Maintenance of Thyroid Hormone Homeostasis: A Study in Adult Rat Brain

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