Maintenance Hemodialysis Decreases Serum Hepatitis C Virus (Hcv) Rna Levels in Hemodialysis Patients With Chronic Hcv Infection

Furusyo, Norihiro; Hayashi, Jun; Ariyama, Iwao; Sawayama, Yasunori; Etoh, Yoshitaka; Shigematsu, Masaru; Kashiwagi, Seizaburo

doi:10.1111/j.1572-0241.2000.01773.x

Cited by 61 publications

(40 citation statements)

References 23 publications

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“…The mechanism of the HBV viral load reduction by HD procedure in our patients may be explained by the suggestions from Furusyo et al's study, investigating the HD effect on hepatitis C viral load, that the viral particles are adsorbed onto the inner surface of membrane during dialysis and destroyed by the pressure applied to blood for dialysis. [17] This viral load reduction through HD may (at least in part) cause low HBV DNA levels in our uremic patients.…”

Section: Discussionmentioning

confidence: 85%

Hemodialysis Reduces the Viral Load in Uremic Patients with Chronic Hepatitis B Infection

et al. 2008

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Background and aims. The effect of hemodialysis (HD) to change the viral load of hepatitis B virus (HBV) in uremic patients with chronic HBV infection has never been studied. In this study, we investigated the HBV viral loads and their changes between the HD procedure in the uremic patients. Patients and methods. A total of 38 chronic HBV-infected uremic patients were enrolled, but eight cases were excluded due to HCV co-infection and under anti-viral therapy. To evaluate the HBV DNA levels and their changes through the course of HD, we quantified serial serum samples from each patient immediately before HD, at the end of HD, and 48 hours later-immediately before the next HD. Results. Most of our HBV-infected uremic patients had a relatively lower HBV viral load; 80% cases with HBV DNA Ϲ4 Log 10 copies/mL, in comparison with the Taiwan epidemiologic study for community base HBV carriers. There was no significant difference of HBV DNA level between HBeAg-positive and -negative patients, but a significant higher DNA level in the high ALT group (p = 0.029) and liver cirrhosis patients (p = 0.002). The mean HBV DNA levels, before and after HD, respectively, in our 30 patients were 3.823 ± 1.130 Log 10 copies/mL and 3.686 ± 1.114 Log 10 copies/mL. It was a significant decrease on HBV DNA level in chronic HBV-infected patients through HD procedure (p = 0.004). The mean HBV DNA level of two days after HD was 3.702 ± 1.094 Log 10 copies/ mL, which was not significantly different from the HBV DNA level before (p = 0.076) or after (p = 0.267) HD; however, the mean reduction of HBV DNA by a single HD was 0.11 ± 0.38 Log 10 copies/mL. Patients with low viral load also had a signifi-

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Section: Discussionmentioning

confidence: 85%

Hemodialysis Reduces the Viral Load in Uremic Patients with Chronic Hepatitis B Infection

et al. 2008

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“…In this paper, we describe confirmation of active infection by RT-nested-PCR in 94.3% of the patients studied. The unconfirmed cases may have been the result of a decrease in viral load observed in this group of patients (Furusyo et al 2000). The occurrence of HCV RNA detectable in patients with negative anti-HCV can be a consequence of immunossupression with decreased production of antibodies, or the window period of a recent infection (Sharara et al 1996, Lok & Gunaratnam 1997.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C and hepatitis B virus infection in different hemodialysis units in Belo Horizonte, Minas Gerais, Brazil

Busek

Baba

Filho

et al. 2002

Mem. Inst. Oswaldo Cruz

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“…Whereas in the study of Fabrizi et al [17] , HCV load was low and relatively stable. HCV RNA levels decreased in dialysis patients in another report [18] . In 1996, we first described the phenomenon in which the number of HCV viral particles decreased after each dialysis procedure and restored to the previous level at the next dialysis [19] .…”

Section: Discussionmentioning

confidence: 99%

“…Our observatrions have since been confirmed. According to Furusyo et al [18] , HCV RNA levels were significantly lower in 98 dialysis patients (0.4 mEq/mL) compared with 228 nonuremic patients (2.0 mEq/mL). The dialysis procedure itself might contribute to the reduction of viral load in the long run.…”

Section: Discussionmentioning

confidence: 99%

Natural history of chronic hepatitis C in patients on hemodialysis: Case control study with 4-23 years of follow-up

Okuda¹,

Yokosuka²

2004

WJG

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AIM: Hepatitis C virus (HCV) infection is very common among end-stage kidney disease patients on hemodialysis, but its natural history is not known. METHODS:In this study, 189 dialysis patients (case) positive for HCV antibodies who were followed up for more than 4 years were compared with twice as many sex/age matched controls with chronic hepatitis C who were diagnosed in the same month as the case and followed up for comparable periods. The longest follow-up was 23 years in dialysis cases. The disease activities were graded into "asymptomatic" if ALT was less than 40 (35 in cases) IU/L, "low activities" if ALT was 40 (35)-79 IU/L, and "high activities" if ALT was above 80 IU/L during the last or latest 4 year period. RESULTS:All 25 dialysis cases who were followed up for more than 15 years were asymptomatic and 15 of them were negative for HCV RNA. Of the 50 controls followed up for more than 15 years, 34 had high activities, and none cleared HCV RNA. There were 60 controls who were asymptomatic, but they were all positive for HCV RNA, while 22.3% of asymptomatic dialysis cases were RNA negative. No dialysis patients with chronic hepatitis C progressed to cirrhosis, whereas the disease progressed to cirrhosis in more than one quarter of the controls. These differences were highly significant (P<0.0001).

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Maintenance Hemodialysis Decreases Serum Hepatitis C Virus (Hcv) Rna Levels in Hemodialysis Patients With Chronic Hcv Infection

Abstract: These observations suggest that maintenance hemodialysis decreases the HCV RNA levels in hemodialysis patients with chronic HCV infection, but does not produce clearance of the viremia.

Cited by 61 publications

References 23 publications

Hemodialysis Reduces the Viral Load in Uremic Patients with Chronic Hepatitis B Infection

Hemodialysis Reduces the Viral Load in Uremic Patients with Chronic Hepatitis B Infection

Hepatitis C and hepatitis B virus infection in different hemodialysis units in Belo Horizonte, Minas Gerais, Brazil

Natural history of chronic hepatitis C in patients on hemodialysis: Case control study with 4-23 years of follow-up

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