Maintenance Deep Transcranial Magnetic Stimulation Sessions are Associated with Reduced Depressive Relapses in Patients with Unipolar or Bipolar Depression

Rapinesi, Chiara; Bersani, Francesco Saverio; Kotzalidis, Georgios D.; Imperatori, Claudio; Casale, Antonio Del; Pietro, Simone Di; Ferri, Vittoria Rachele; Serata, Daniele; Raccah, Ruggero; Zangen, Abraham; Angeletti, Gloria; Girardi, Paolo

doi:10.3389/fneur.2015.00016

Cited by 40 publications

(27 citation statements)

References 28 publications

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“…While cTBS is used to inhibit certain brain regions, other TMS protocols could be applied to improve the access to bodily sensations and empower concomitant therapeutic approaches as demonstrated for various disorders, e.g. in the decrease of relapse rates in depression [73]. More clinical research is needed to further elucidate future therapeutic avenues.…”

Section: Discussionmentioning

confidence: 99%

Changes in interoceptive processes following brain stimulation

Pollatos

Herbert

Mai

et al. 2016

Phil. Trans. R. Soc. B

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The processing and perception of individual internal bodily signals (interoception) has been differentiated to comprise different levels and processes involved. The so-called heartbeat-evoked potential (HEP) offers an additional possibility to examine automatic processing of cardiac signals. Knowledge on neural structures potentially supporting different facets of interoception is still sparse. One way to get insights into neuroanatomical function is to manipulate the activity of different brain structures. In this study, we used repetitive transcranial magnetic stimulation (rTMS) and a continuous theta-burst protocol to inhibit specific central locations of the interoceptive network including the right anterior insula and the right somatosensory cortices and assessed effects on interoceptive facets and the HEP in 18 male participants. Main results were that inhibiting anterior insula resulted in a significant decline in cardiac and respiratory interoceptive accuracy (IAc) and in a consistent decrease in perception confidence. Continuous theta-burst stimulation (cTBS) over somatosensory cortices reduced only cardiac IAc and affected perception confidence. Inhibiting right anterior insula and right somatosensory cortices increased interoceptive sensibility and reduced the HEP amplitude over frontocentral locations. Our findings strongly suggest that cTBS is an effective tool to investigate the neural network supporting interoceptive processes. This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.

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Section: Discussionmentioning

confidence: 99%

Changes in interoceptive processes following brain stimulation

Pollatos

Herbert

Mai

et al. 2016

Phil. Trans. R. Soc. B

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“…Previous studies reported a reduction of nicotine [20] and alcohol craving after cycles of deep transcranial magnetic stimulation (dTMS) over bilateral DLPFC [21][22][23]. In addition, a single session of repetitive TMS (rTMS) over the right DLPFC significantly reduced cocaine craving, a reduction that persisted four hours after the end of the session [7].…”

Section: Introductionmentioning

confidence: 94%

Add-on high frequency deep transcranial magnetic stimulation (dTMS) to bilateral prefrontal cortex reduces cocaine craving in patients with cocaine use disorder

Rapinesi

Casale

Pietro

et al. 2016

Neuroscience Letters

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“…One study reported reduced relapse rate with continued maintenance TMS two times weekly and then weekly. The results suggested that maintenance TMS might be helpful in preventing affective episode relapses in a 12-month follow-up period (69).…”

Section: Transcranial Magnetic Stimulation Tms In Major Depressive DImentioning

confidence: 93%

Recent Developments in Noninvasive Neuromodulation for Mood and Anxiety Disorders

Rakesh

Lisanby

2015

Curr Behav Neurosci Rep

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Noninvasive neuromodulation refers to a family of device-based interventions that apply electrical or magnetic fields, either at convulsive or subconvulsive levels, to the brain through the intact skull to modulate neural function. This is a rapidly evolving field, with new research emerging regarding the various roles that these devices can play both in studying the neural mechanisms underlying mood and anxiety disorders, and in treating pharmacoresistant conditions either on their own or in combination with other therapies. Each neuromodulation modality has its pros and cons and should be carefully chosen after weighing the risks and benefits. This manuscript reviews some of the most exciting developments in this field over the past year and emphasizes themes that are emerging as being important for these tools to fulfill their potential to transform how we study and treat mood and anxiety disorders. Key among these themes is the concept of how we understand the "dose" of the stimulation, and how exogenously applied fields interact with endogenous brain activity. Refining the concept of dose will ultimately be important in allowing clinicians and researchers to apply the procedure with precision to engage the targeted network to achieve the desired effects in each individual. The large parameter space defining dose of neuromodulation makes interpreting the literature on safety and efficacy challenging and highlights the need for clear and accurate reporting of the spatial, temporal, and contextual features of dosage to make the emerging literature base as informative as possible. Ultimately, the impact of noninvasive neuromodulation devices is potentially transformational given their utility in providing mechanistic insight into the circuitbased and oscillatory origins of mood and anxiety disorders, as well as providing therapeutic interventions rationally designed to target disease-related processes.

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Maintenance Deep Transcranial Magnetic Stimulation Sessions are Associated with Reduced Depressive Relapses in Patients with Unipolar or Bipolar Depression

Cited by 40 publications

References 28 publications

Changes in interoceptive processes following brain stimulation

Changes in interoceptive processes following brain stimulation

Add-on high frequency deep transcranial magnetic stimulation (dTMS) to bilateral prefrontal cortex reduces cocaine craving in patients with cocaine use disorder

Recent Developments in Noninvasive Neuromodulation for Mood and Anxiety Disorders

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