Maintaining Quality in Endoscopy

Balakrishnan, Anita; Lewis, Stephen J.; Hosie, Kenneth B.

doi:10.5772/22022

Cited by 1 publication

(2 citation statements)

References 114 publications

(116 reference statements)

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“…Another source of potential variations can be determined from hemodynamics studies, as have been reported from Balakrishnan, et al and Kolachalama, et al, among others [21][22][23]48]. In these studies flow pattems can vary circumferentially and alter distributions of proximal compared to distal drug distributions in-stent.…”

Section: Discussionmentioning

confidence: 94%

“…This occurs through the use of several different transport scenarios. For instance, hemodynamic analysis coupled to convective/diffusive transport analysis provides a direct link between intraluminal fluid pressures, shear stress, and the convective component of transport [21][22][23]. Coupled multidomain approaches have offered the ability to show how shear force on endothelial cells or changes in the hemodynamic environment due to anatomical reasons can alter observed depositions of drugs or albumin [24,25].…”

Section: Introductionmentioning

confidence: 99%

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A Finite Element Study on Variations in Mass Transport in Stented Porcine Coronary Arteries Based on Location in the Coronary Arterial Tree

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Simon

Geest

2013

Journal of Biomechanical Engineering

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Drug-eluting stents have a significant clinical advantage in late-stage restenosis due to the antiproliferative drug release. Understanding how drug transport occurs between coronary arterial locations can better help guide localized drug treatment options. Finite element models with properties from specific porcine coronary artery sections (left anterior descending (LAD), right (RCA); proximal, middle, distal regions) were created for stent deployment and drug delivery simulations. Stress, strain, pore fluid velocity, and drug concentrations were exported at different time points of simulation (0-180 days). Tests indicated that the highest stresses occurred in LAD sections. Higher-than-resting homeostatic levels of stress and strain existed at upwards of 3.0 mm away from the stented region, whereas concentration of species only reached 2.7 mm away from the stented region. Region-specific concentration showed 2.2 times higher concentrations in RCA artery sections at times corresponding to vascular remodeling (peak in the middle segment) compared to all other segments. These results suggest that wall transport can occur differently based on coronary artery location. Awareness of peak growth stimulators and where drug accumulation occurs in the vasculature can better help guide local drug delivery therapies.

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Section: Discussionmentioning

confidence: 94%