Maintaining Muscle Strength in Crohn’s Disease: Can a Vitamin D Daily Keep Muscle Loss Away?

Langenberg, Daniel R. van

doi:10.1007/s10620-012-2543-3

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…However, to our knowledge this is the first review to highlight the potential of exercise to significantly improve upper and lower limb muscular endurance. Despite significantly impaired muscular function identified in IBD [61][62][63][64], and its association with reduced QOL, morbidity, mortality and further disability in other chronic conditions it remains one of the least researched extra-intestinal manifestations with IBD [65,66]. These findings highlight the importance of detecting muscle weakness in people with IBD as part of routine clinical care and integrating exercise interventions to manage and prevent the development of musculoskeletal extraintestinal manifestations.…”

Section: Plos Onementioning

confidence: 99%

Effects of structured exercise programmes on physiological and psychological outcomes in adults with inflammatory bowel disease (IBD): A systematic review and meta-analysis

Jones

Kimble²,

Baker

et al. 2022

PLoS ONE

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Background Exercise has been suggested to counteract specific complications of inflammatory bowel disease (IBD). However, its role as a therapeutic option remains poorly understood. Therefore, we conducted a systematic review and meta-analysis on the effects of exercise in IBD. Methods Five databases (MEDLINE, Embase, CINAHL, CENTRAL and SPORTDiscus) and three registers (Clinicaltrials.gov, WHO ICTRP and ISRCTN) were searched from inception to September 2022, for studies assessing the effects of structured exercise of at least 4 weeks duration on physiological and/or psychological outcomes in adults with IBD. Two independent reviewers screened records, assessed risk of bias using the Cochrane Risk of Bias (RoB 2.0) and ROBINS-I tools, and evaluated the certainty of evidence using the GRADE method. Data were meta-analysed using a random-effects model. Results From 4,123 citations, 15 studies (9 RCTs) were included, comprising of 637 participants (36% male). Pooled evidence from six RCTs indicated that exercise improved disease activity (SMD = -0.44; 95% CI [-0.82 to -0.07]; p = 0.02), but not disease-specific quality of life (QOL) (IBDQ total score; MD = 3.52; -2.00 to 9.04; p = 0.21) when compared to controls. Although meta-analysis could not be performed for other outcomes, benefits were identified in fatigue, muscular function, body composition, cardiorespiratory fitness, bone mineral density and psychological well-being. Fourteen exercise-related non-serious adverse events occurred. The overall certainty of evidence was low for disease activity and very low for HRQOL as a result of downgrading for risk of bias and imprecision. Conclusions Structured exercise programmes improve disease activity, but not disease-specific QOL. Defining an optimal exercise prescription and synthesis of evidence in other outcomes, was limited by insufficient well-designed studies to ascertain the true effect of exercise training. This warrants further large-scale randomised trials employing standard exercise prescription to verify this effect to enable the implementation into clinical practice. Registration This systematic review was prospectively registered in an international database of systematic reviews in health-related research (CRD42017077992; https://www.crd.york.ac.uk/prospero/).

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Section: Plos Onementioning

confidence: 99%

Effects of structured exercise programmes on physiological and psychological outcomes in adults with inflammatory bowel disease (IBD): A systematic review and meta-analysis

Jones

Kimble²,

Baker

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

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“…There is growing evidence that vitamin D (vitD) may alter skeletal muscle function and strength (2) . Our aim was to investigate the effects of vitD supplementation on muscle function and, correspondingly, on fatigue and QoL in patients with stable CD.…”

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confidence: 99%

“…Reduced muscle strength, fatigue and poor quality of life (QoL) are frequently reported in Crohn's disease (CD) even in remission ( 1 ) . There is growing evidence that vitamin D (vitD) may alter skeletal muscle function and strength ( 2 ) . Our aim was to investigate the effects of vitD supplementation on muscle function and, correspondingly, on fatigue and QoL in patients with stable CD.…”

mentioning

confidence: 99%

Supplemental vitamin D in quiescent Crohn's disease – effects on quality of life, fatigue and muscle strength: results from a double blind placebo controlled study

et al. 2013

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Reduced muscle strength, fatigue and poor quality of life (QoL) are frequently reported in Crohn's disease (CD) even in remission (1) . There is growing evidence that vitamin D (vitD) may alter skeletal muscle function and strength (2) . Our aim was to investigate the effects of vitD supplementation on muscle function and, correspondingly, on fatigue and QoL in patients with stable CD. In a double-blind placebo controlled study, 27 subjects with CD in remission were randomized to 2000 IU vitD3/d or placebo for 3mo. The primary outcome measures were changes in hand-grip strength (HGS) (Jamar Digital Hand Dynamometer), fatigue (Multi-fatigue inventory, MFI) and QoL (Inflammatory Bowel Disease questionnaire, IBDQ). At 0 and 3mo, disease activity (CD activity index, CDAI), FBC, CRP (mg/l) and serum 25(OH)D (nmol/l) were also measured. Ethical approval and informed written consent were obtained and the research was performed in accordance to the Declaration of Helsink.At enrolment mean ( In conclusion, oral daily supplementation with 2000IU vitd3/d for 3mo significantly increased dominant and non-dominant HGS compared to placebo. Achieving serum 25(OH)D levels of 75 nmol/l or greater was associated with increased QOL and reduced fatigue scores. These findings, to our knowledge, are the first to suggest potential benefits of vitD on muscle strength with corresponding benefits for fatigue and QOL in CD, and merit investigation in larger controlled studies.

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Maintaining Muscle Strength in Crohn’s Disease: Can a Vitamin D Daily Keep Muscle Loss Away?

Cited by 2 publications

References 12 publications

Effects of structured exercise programmes on physiological and psychological outcomes in adults with inflammatory bowel disease (IBD): A systematic review and meta-analysis

Effects of structured exercise programmes on physiological and psychological outcomes in adults with inflammatory bowel disease (IBD): A systematic review and meta-analysis

Supplemental vitamin D in quiescent Crohn's disease – effects on quality of life, fatigue and muscle strength: results from a double blind placebo controlled study

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