Maintaining Coral Snakes (Micrurus nigrocinctus, Serpentes: Elapidae) for venom production on an alternative fish-based diet

Chacón, Danilo; Rodríguez, Santos; Arias, Javier Carrasco; Solano, Gabriela; Bonilla, Fabián; Gómez, Aarón

doi:10.1016/j.toxicon.2012.04.332

Cited by 18 publications

(16 citation statements)

References 26 publications

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“…One important aspect while keeping this species in captivity is the production of anti-venoms and researching its toxins. However, it is known that the maintenance of many species of Micrurus in captivity is difficult, largely due to the lack of knowledge of its natural habits in the wild and the consequential difficulty of capture (Ciscotto et al, 2011) Additionally, the feeding process in captivity is difficult because a maladaptation syndrome (Roze, 1996;Chacón et al, 2012;Renjifo et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…adults (dead or alive). Additionally, the coral snakes had never lived more than six months in captivity in our institution and the known life expectancy for Micrurus specimens rarely exceeds one year (Chacón et al, 2012). Therefore, it is necessary to evaluate alternatives to standardize protocols for the maintenance of these species in captivity.…”

Section: Introductionmentioning

confidence: 99%

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Maintenance of red-tail coral snake (Micrurus mipartitus) in captivity and evaluation of individual venom variability

Duque

Rangel

2016

Acta biol. Colomb.

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Red-tail coral snake (Micrurus mipartitus) is a long and thin bicolor coral snake widely distributed in Colombia and is the coral that causes the majority of accidents in the Andean region, so it is important to keep this species in captivity for anti-venom production and research. However, maintaining this species in captivity is very difficult because it refuses to feed, in addition to the high mortality rate due to maladaptation syndrome. In this study a force feeding diet, diverse substrates for maintenance and a milking technique were evaluated. Additionally, individual variability of the venom was determined by High Performance Liquid Chromatography (HPLC), Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (SDS-PAGE) and Coagulant, Anticoagulant and Hemolytic activities. The results of this study demonstrate that it was possible to increase the survival rate of this species in captivity and to determine some of the important factors in the maintenance. As to the individual variability of the venom, we found differences in number and intensity of peaks recovered by chromatography and also displayed variations in some of its biological activities.Keywords: antivenom, force-feeding, mortality. RESUMENLa coral "rabo de ají" es una coral bicolor larga y delgada. Esta especie está ampliamente distribuida en Colombia y es la coral que causa el mayor número de accidentes en la región Andina, por esto es importante mantener esta especie en cautiverio con fines de producción de antivenenos e investigación. No obstante, el mantenimiento de esta especie en cautiverio es difícil, debido a que se rehúsan a alimentarse voluntariamente y a que presentan alta mortalidad por el denominado síndrome de mal adaptación. En este estudio se evaluaron varios sustratos para el mantenimiento, además de una dieta forzada y una técnica de ordeño. Adicionalmente, se evaluó la variabilidad individual del veneno a través de cromatografía liquida de alta eficiencia (HPLC), electroforesis (SDS-PAGE) y las actividades coagulante, anticoagulante y hemolítica indirecta. Los resultados de este estudio demostraron que fue posible incrementar la sobrevivencia de esta especie en cautiverio, así como determinar algunos factores importantes en su mantenimiento. A partir de la evaluación del veneno se encontraron diferencias en el número y en la intensidad de picos en la cromatografía, así como en algunas de sus actividades biológicas.Palabras clave: alimentación forzada, antiveneno, mortalidad.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maintenance of red-tail coral snake (Micrurus mipartitus) in captivity and evaluation of individual venom variability

Duque

Rangel

2016

Acta biol. Colomb.

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“…A vítima deve ser hospitalizada por um período mínimo de 48 horas para monitoramento contínuo (Peterson, 2006). O único tratamento definitivo para o envenenamento é a administração do soro (FUNASA, 2001;WHO, 1981 (Chacón et. al., 2012).…”

Section: Envenenamentosunclassified

“…Sabe-se também que as serpentes do gênero Micrurus são de pequeno e médio porte com tamanho em torno de um metro (FUNASA, 2001), produzindo reduzidas quantidades de veneno, e que sua manutenção em cativeiro é bastante complexa (Chacón et. al., 2012), fato que dificulta a obtenção do veneno em quantidades suficientes para a produção de soro, gerando sua escassez.…”

Section: Tratamentounclassified

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Uso de venenos de serpentes australianas como potencial alternativa para a produção de soro anti-elapídico

Silva¹

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Variation in venom yield and protein concentration of the centipedes Scolopendra polymorpha and Scolopendra subspinipes

Cooper

Fox

Nelsen

et al. 2014

Toxicon

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Maintaining Coral Snakes (Micrurus nigrocinctus, Serpentes: Elapidae) for venom production on an alternative fish-based diet

Cited by 18 publications

References 26 publications

Maintenance of red-tail coral snake (Micrurus mipartitus) in captivity and evaluation of individual venom variability

Maintenance of red-tail coral snake (Micrurus mipartitus) in captivity and evaluation of individual venom variability

Uso de venenos de serpentes australianas como potencial alternativa para a produção de soro anti-elapídico

Variation in venom yield and protein concentration of the centipedes Scolopendra polymorpha and Scolopendra subspinipes

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