The literature on the modeling and management of data generated through the lifecycle of a manufacturing system is split into two main paradigms: product lifecycle management (PLM) and product, process, resource (PPR) modeling. These paradigms are complementary, and the latter could be considered a more neutral version of the former. There are two main technologies associated with these paradigms: ontologies and databases. Database technology is widespread in industry and is well established. Ontologies remain largely a plaything of the academic community which, despite numerous projects and publications, have seen limited implementations in industrial manufacturing applications. The main objective of this paper is to provide a comparison between ontologies and databases, offering both qualitative and quantitative analyses in the context of PLM and PPR. To achieve this, the article presents (1) a literature review within the context of manufacturing systems that use databases and ontologies, identifying their respective strengths and weaknesses, and (2) an implementation in a real industrial scenario that demonstrates how different modeling approaches can be used for the same purpose. This experiment is used to enable discussion and comparative analysis of both modeling strategies.