Main influencing factors and health-related quality of life issues in patients with oesophago-gastric cancer – as measured by EORTC tools

Tomaszewski, Krzysztof A.; Püsküllüoğlu, Mirosława; Biesiada, Katarzyna; Bochenek, Justyna; Ochenduszko, Sebastián; Tomaszewska, Iwona M.; Krzemieniecki, Krzysztof

doi:10.5114/wo.2013.35280

Cited by 6 publications

(11 citation statements)

References 21 publications

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“…However, the authors considered that this symptom seemed to be physiologically unrelated to postoperative complications 14 . Insomnia was also considered more as psychological issues than physiological ones 40 . This may be one of the reasons why the scores of insomnia item fluctuated.…”

Section: Discussionmentioning

confidence: 99%

Comparison of quality of life between Billroth-І and Roux-en-Y anastomosis after distal gastrectomy for gastric cancer: A randomized controlled trial

Yang

Zhang

Liu

et al. 2017

Sci Rep

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Studies comparing Billroth-I (B-I) with Roux-en-Y (R-Y) anastomosis are still lacking and inconsistent. The aim of this trial was to compare the quality of life (QoL) of B-I with R-Y reconstruction after curative distal gastrectomy for gastric cancer. A total of 140 patients were randomly assigned to the B-I group (N = 70) and R-Y group (N = 70) with the comparable baseline characteristics. The overall postoperative morbidity rates were 18.6% and 25.7% in the B-I group and R-Y group without significant difference. More estimated blood loss and longer surgical duration were found in the R-Y group. At the postoperative 1 year time point, the B-I group had a higher score in pain, but lower score in global health. However, the R-Y anastomosis was associated with lower incidence of reflux symptoms at postoperative 6 months (P = 0.002) and postoperative 9 months (P = 0.007). The multivariable analyses of variance did not show any interactions between the time trend and grouping. For the results of endoscopic examination, the degree and extent of remnant gastritis were milder significantly in the R-Y group. The stronger anti-reflux capability of R-Y anastomosis contributes to the higher QoL by reducing the reflux related gastritis and pain symptoms, and promotes a better global health.

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Section: Discussionmentioning

confidence: 99%

Comparison of quality of life between Billroth-І and Roux-en-Y anastomosis after distal gastrectomy for gastric cancer: A randomized controlled trial

Yang

Zhang

Liu

et al. 2017

Sci Rep

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“…Particularly noteworthy are the associations with socio-demographic factors that can be observed across almost all domains. While the association with age and gender is observed in almost all HRQoL studies [33], the positive correlation between HRQoL and early retirement/old age pension is not a general finding in oncology [34,35]. It seems possible that with the removal of occupational demands, mental and physical capacities are released, which ultimately has a positive effect on HRQoL.…”

Section: Results In Contextmentioning

confidence: 97%

The Health-Related Quality of Life of Sarcoma Patients and Survivors in Germany—Cross-Sectional Results of a Nationwide Observational Study (PROSa)

Eichler

Hentschel

Richter

et al. 2020

Cancers

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Sarcomas are rare cancers with high heterogeneity in terms of type, location, and treatment. The health-related quality of life (HRQoL) of sarcoma patients has rarely been investigated and is the subject of this analysis. Adult sarcoma patients and survivors were assessed between September 2017 and February 2019 in 39 study centers in Germany using standardized, validated questionnaires (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30)). Associated factors were analyzed exploratively using multivariable linear regressions. Among 1113 patients, clinically important limitations and symptoms were most pronounced in emotional (63%, 95% CI 60–66%), physical (60%, 95% CI 57–62%), role functioning (51%, 95% CI 48–54%), and pain (56%, 95% CI 53–59%) and fatigue (51%, 95% CI 48–54%). HRQoL differed between tumor locations with lower extremities performing the worst and sarcoma types with bone sarcoma types being most affected. Additionally, female gender, higher age, lower socioeconomic status, recurrent disease, not being in retirement, comorbidities, and being in treatment were associated with lower HRQoL. Sarcoma patients are severely restricted in their HRQoL, especially in functioning scales. The heterogeneity of sarcomas with regard to type and location is reflected in HRQoL outcomes. During treatment and follow-up, close attention has to be paid to the reintegration of the patients into daily life as well as to their physical abilities and emotional distress.

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“…Elder patients were more likely to report problems in the pain/discomfort dimension. Tomaszewski et al reported that oesophagogastric cancer patients aged ≥60 years had higher pain and discomfort scores than patients aged <60 years . In general, the HRQoL of elder patients is always significantly lower owing to the decline in physical function and the poor endurance capacity.…”

Section: Discussionmentioning

confidence: 99%

Health‐related quality of life of esophageal cancer patients in daily life after treatment: A multicenter cross‐sectional study in China

et al. 2018

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BackgroundThe improvement of diagnostic and therapeutic techniques has prolonged the survival time of patients with esophageal cancer. Little is known, however, about their health‐related quality of life (HRQoL) in daily life after treatment.MethodsEsophageal cancer patients who had been discharged from hospitals more than one year and healthy controls identified by screening were recruited from seven study centers covering eastern, central, and western regions of China. Patients were categorized into severe dysplasia/carcinoma in situ and stages I, II, III, and IV cancer, respectively. The EQ‐5D was employed to assess HRQoL. Multivariate regression analyses were conducted.ResultsA total of 1456 patients and 2179 controls were recruited. After adjusting for potential confounding factors, the likelihood of reporting problems in the five dimensions of patients was 3.8 to 23.1 times higher than controls, whilst the mean EQ‐5D utility score was 0.311 (95% CI, 0.276‐0.346) lower than controls. The mean utility scores of each patient subgroup were 0.158, 0.289, 0.303, 0.296, and 0.505 (95% CIs: 0.108‐0.208, 0.243‐0.336, 0.261‐0.346, 0.244‐0.347, and 0.437‐0.573) lower than controls, respectively. Patients had the greatest impairment in the self‐care dimension compared with controls, followed by the usual activities dimension. Therapeutic regimen, duration of illness, other chronic disease status, age, and marital status also had significant impact on different aspects of HRQoL in patients.ConclusionsEsophageal cancer significantly impaired patients' HRQoL in daily life after treatment. Advanced cancer stages were associated with larger decrements on health state utility. Utility scores reported here can facilitate further cost‐utility analyses.

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Main influencing factors and health-related quality of life issues in patients with oesophago-gastric cancer – as measured by EORTC tools

Cited by 6 publications

References 21 publications

Comparison of quality of life between Billroth-І and Roux-en-Y anastomosis after distal gastrectomy for gastric cancer: A randomized controlled trial

Comparison of quality of life between Billroth-І and Roux-en-Y anastomosis after distal gastrectomy for gastric cancer: A randomized controlled trial

The Health-Related Quality of Life of Sarcoma Patients and Survivors in Germany—Cross-Sectional Results of a Nationwide Observational Study (PROSa)

Health‐related quality of life of esophageal cancer patients in daily life after treatment: A multicenter cross‐sectional study in China

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