Main Histologic Types of Non–Small-Cell Lung Cancer Differ in Expression of Prognosis-related Genes

Skrzypski, Marcin; Dziadziuszko, Rafał; Jassem, Ewa; Szymanowska-Narloch, Amelia; Gulida, G.; Rzepko, Robert; Biernat, Wojciech; Tarón, Miquel; Jelitto-Górska, Małgorzata; Marjański, Tomasz; Rzyman, Witold; Rosell, Rafael; Jassem, Jacek

doi:10.1016/j.cllc.2013.04.010

Cited by 35 publications

(27 citation statements)

References 44 publications

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“…For BAC, a subset of adenocarcinoma, there was an association with improved outcome in older patients, but this was not present in younger patients. The reasons for this difference are unclear, but it is possible that there may be unseen imbalances in the distribution of molecular features across both age groups and histologic subtypes that could have influenced subsequent prognosis [15].…”

Section: Discussionmentioning

confidence: 99%

Predictors of survival for younger patients less than 50 years of age with non-small cell lung cancer (NSCLC): A California Cancer Registry analysis

Lara¹,

Brunson

Wun

et al. 2014

Lung Cancer

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Section: Discussionmentioning

confidence: 99%

Predictors of survival for younger patients less than 50 years of age with non-small cell lung cancer (NSCLC): A California Cancer Registry analysis

Lara¹,

Brunson

Wun

et al. 2014

Lung Cancer

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“…Accordingly, high TAM densities correlate strongly with metastatic breast cancer, and high CSF-1 levels coincide with dense TAM foci at invading fronts of breast cancers [55,61,62,63]. High TAM counts are associated with a poor prognosis in a number of cancers, including cervical cancer, endometrial cancer, prostate cancer, lung cancer, pancreatic cancer and glioblastoma [64,65,66,67,68,69]. …”

Section: Macrophage Motility and Csf-1 In Cancermentioning

confidence: 99%

Promotion of Tumor Invasion by Tumor-Associated Macrophages: The Role of CSF-1-Activated Phosphatidylinositol 3 Kinase and Src Family Kinase Motility Signaling

Dwyer

Greenland

Pixley

2017

Cancers

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Macrophages interact with cells in every organ to facilitate tissue development, function and repair. However, the close interaction between macrophages and parenchymal cells can be subverted in disease, particularly cancer. Motility is an essential capacity for macrophages to be able to carry out their various roles. In cancers, the macrophage’s interstitial migratory ability is frequently co-opted by tumor cells to enable escape from the primary tumor and metastatic spread. Macrophage accumulation within and movement through a tumor is often stimulated by tumor cell production of the mononuclear phagocytic growth factor, colony-stimulating factor-1 (CSF-1). CSF-1 also regulates macrophage survival, proliferation and differentiation, and its many effects are transduced by its receptor, the CSF-1R, via phosphotyrosine motif-activated signals. Mutational analysis of CSF-1R signaling indicates that the major mediators of CSF-1-induced motility are phosphatidyl-inositol-3 kinase (PI3K) and one or more Src family kinase (SFK), which activate signals to adhesion, actin polymerization, polarization and, ultimately, migration and invasion in macrophages. The macrophage transcriptome, including that of the motility machinery, is very complex and highly responsive to the environment, with selective expression of proteins and splice variants rarely found in other cell types. Thus, their unique motility machinery can be specifically targeted to block macrophage migration, and thereby, inhibit tumor invasion and metastasis.

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“…Another study addressing prognostic significance of miRNA expression did not account for NSCLC subtypes in the validation phase (Yu et al , 2008). Owing to different expression of several miRNAs or mRNAs in particular histological types of NSCLC, prognostic analyses including more than one subtype of NSCLC are questionable (Landi et al , 2010; Skrzypski et al , 2013). In the current study, we investigated whether miRNA expression may predict disease dissemination in operable squamous cell lung carcinoma (SCC), which in many countries still constitutes the major histological subtype of NSCLC.…”

mentioning

confidence: 99%

Prognostic value of microRNA expression in operable non-small cell lung cancer patients

et al. 2014

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Background:About 50% of non-small cell lung cancer (NSCLC) patients develop distant metastases following pulmonary resection. Currently, there are no reliable factors allowing for individual selection of high-risk patients for adjuvant systemic therapies.Methods:We assessed by quantitative reverse transcription PCR microRNA (miRNA) expression in 273 stage I–IIIA NSCLC samples. Expression of 677 miRNAs was evaluated in fresh-frozen tumour samples in the training cohort of 50 squamous cell carcinoma (SCC) patients who underwent curative surgery. Of those, 20 patients developed distant metastases, and 30 were free of recurrence for >4 years. In the second step, miRNAs with highest predictive value for distant relapse were re-evaluated in formalin-fixed paraffin-embedded material in an independent group of 134 stage I–IIIA SCC patients. Additionally, the same miRNAs were investigated in 89 lung adenocarcinoma (AC) patients and in normal lung parenchyma (NLP).Results:In the training cohort of SCC, six miRNAs were differently expressed in the non-recurrent vs recurrent groups and correlated with distant recurrence-free survival, however none reached the level of significance after correction for multiple testing. Of these six miRNAs, miR-662, -192 and -192* were confirmed as prognostic in the independent SCC cohort. Expression of miR-128, -10b, -502-3p and -192 differed between SCC and AC, and miR-128 and -192 – between NLP and NSCLC.Conclusions:We identified three new miRNAs predictive of distant relapse in operable SCC. Future miRNA studies should account for differences between NSCLC subtypes.

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Main Histologic Types of Non–Small-Cell Lung Cancer Differ in Expression of Prognosis-related Genes

Cited by 35 publications

References 44 publications

Predictors of survival for younger patients less than 50 years of age with non-small cell lung cancer (NSCLC): A California Cancer Registry analysis

Predictors of survival for younger patients less than 50 years of age with non-small cell lung cancer (NSCLC): A California Cancer Registry analysis

Promotion of Tumor Invasion by Tumor-Associated Macrophages: The Role of CSF-1-Activated Phosphatidylinositol 3 Kinase and Src Family Kinase Motility Signaling

Prognostic value of microRNA expression in operable non-small cell lung cancer patients

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