Main group metal complexes of semicarbazones and thiosemicarbazones. A structural review

Anti-parasitic action and elimination of intracellular Toxoplasma gondii in the presence of novel thiosemicarbazone and its 4-thiazolidinone derivatives

“…This chemical structure showed anti-parasitic effects similar to those described by Tenório et al (14). The best compound was acid [2-(benzylidenehydrazone)-4-oxo-1,3-thiazolidin-5-yl]acetic, that had an The mechanism of action of TSC and TZD compounds is mainly associated with ribonucleotide reductase inhibition, as is that of HU (29), but it may also involve inhibition of other metallic proteins involved in metabolic processes.…”

“…The ability of TSC to arrest the cell cycle has been used in a variety of situations, such as antitumoral, antiviral, and anti-protozoa treatments (29,30). Another TSC, Triapine ® , has also shown significant activity on tumor cells (31) and was tested in a phase I clinical trial.…”

Chemistry, antiproliferative activity and low nephrotoxicity of 3,5-diacetyl-1,2,4-triazol bis(4N-thiosemicarbazone) ligands and their platinum(ii) complexes

“…40 Interestingly, the flexibility of the ligand originating from the free rotation of the two thiosemicarbazone arms around the C(2)-C(3) and C(4)-C(5) single bonds, allows the ligand to ligate the two metal ions in a twist conformation generating two parallel coordination planes. 35 Particularly, between the two triazole moi-45 eties, the interplane separation being 3.27 Å is considered optimal for p-p interactions (intramolecular stacking). This arrangement is reinforced by intramolecular hydrogen bonds between the 2 NH of the bridging thiosemicarbazone moieties and uncoordinated triazole nitrogen atoms [N(7)-H(7) ◊ ◊ ◊ N(6) 2.755(7) Å ].…”

Synthesis and Conjoint Experimental-DFT Characterization of Some Pyrazolone Functionalized Dioxovanadium (V) Schiff Base Complexes

“…A variety of semicarbazones and their metal complexes have been reported to possess properties of wide variation in their stereochemistry and modes of bonding through oxygen and azomethine nitrogen atoms [14]. The metal binding properties in semicarbazones are tailored and appended by tagging with different additional donor atoms involving substituted aldehydes or ketones [18][19][20][21] witnessed by a number of reports of the same field of investigation [22][23][24]. Vanadium (V) complexes have been shown to ensue stereo-chemically flexible coordination geometries [25].…”