Main Constituents and Antidiabetic Properties of <i>Otholobium mexicanum</i>

Suárez, Alírica I.; Thu, Zaw Min; Ramírez, Jorge; León, Diana Carolina Rubio; Cartuche, Luis; Armijos, Chabaco; Vidari, Geovanni

doi:10.1177/1934578x1701200418

Cited by 5 publications

(6 citation statements)

References 21 publications

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“…Indeed, pancreatic and intestinal glucosidases are the key enzymes of dietary carbohydrate digestion, and inhibitors of these enzymes may be effective in slowing glucose absorption to suppress postprandial hyperglycemia. In this context, it is significant to mention that the extracts and phenolic or flavonoid contents of Gaiadendron punctatum [73], Muehlenbeckia tamnifolia [93], Oreocallis grandiflora [19], and Otholobium mexicanum [56], as well as trans-tiliroside (22) [53], prenyloxy eriodictyol (92), and rhamnetin (101) [96], showed enzymatic inhibitory activity that was comparable or superior to acarbose, which is a drug that is currently used in the treatment of diabetes mellitus. Therefore, these results should promote studies on determining whether these hypoglycemic products can become sources of new antidiabetic drugs.…”

Section: Discussionmentioning

confidence: 99%

“…Bakuchiol (24), hydroxybakuchiol (25), daidzin (26), and genistin (27) (Figure 5) were isolated from a leaf methanolic extract and identified using NMR spectroscopy [56].…”

Section: W (Grimes) Culenmentioning

confidence: 99%

“…Daidzin (26) and genistin (27) exhibited lower inhibitory activity, with IC 50 values of 564 and 913 µM, respectively. Bakuchiol (24) exhibited poor inhibitory activity, with an inhibition percentage less than 10% at the maximum dose tested (1 mM) [56].…”

Section: W (Grimes) Culenmentioning

confidence: 99%

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Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

et al. 2021

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The use of plants as therapeutic agents is part of the traditional medicine that is practiced by many indigenous communities in Ecuador. The aim of this study was to update a review published in 2016 by including the studies that were carried out in the period 2016–July 2021 on about 120 Ecuadorian medicinal plants. Relevant data on raw extracts and isolated secondary metabolites were retrieved from different databases, resulting in 104 references. They included phytochemical and pharmacological studies on several non-volatile compounds, as well as the chemical composition of essential oils (EOs). The tested biological activities are also reported. The potential of Ecuadorian plants as sources of products for practical applications in different fields, as well the perspectives of future investigations, are discussed in the last part of the review.

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Section: Discussionmentioning

confidence: 99%

“…Bakuchiol (24), hydroxybakuchiol (25), daidzin (26), and genistin (27) (Figure 5) were isolated from a leaf methanolic extract and identified using NMR spectroscopy [56].…”

Section: W (Grimes) Culenmentioning

confidence: 99%

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Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

et al. 2021

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“…In addition, a previous study has confirmed that orally administering bakuchiol reduces blood glucose levels in db/db mice with type 2 diabetes [ 15 ]. A compound called 3-hydroxybakuchiol (HYD) with a similar structure to bakuchiol has been discovered in Otholobium mexicanum, showing potential anti-diabetic activity [ 17 , 18 ]. This suggested a potential anti-diabetic activity of HYD.…”

Section: Introductionmentioning

confidence: 99%

Integrated investigation and discovery of therapeutic targets for 3-hydroxybakuchiol against diabetes based on molecular docking studies and cell experiments

Liu,

Wang,

Yang

et al. 2023

BMC Complement Med Ther

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Background Diabetes mellitus is a prevalent endocrine condition. We aimed to investigate the anti-diabetic effects of 3-hydroxybakuchiol (HYD) by exploring its potential targets and molecular mechanisms through bioinformatics analysis and cell experiments. Methods We performed an extensive search and screening of HYD and its potential targets for diabetes mellitus across various databases. Enrichment analyses were conducted using the ClusterProfiler package. PPI networks of the identified genes were constructed using STRING, and topological analysis was performed to identify core targets. The results were further confirmed through molecular docking. To validate the findings of our bioinformatics analysis, we conducted cell experiments using insulin resistance-induced HepG2 cells and C2C12 cells. Results We discovered 260 common targets of HYD and diabetes mellitus, which were primarily related to the MAPK signaling pathway, PI3K-Akt signaling pathway, and endocrine resistance. A topological analysis of the PPI network identified four core targets (HSP90AA1, AKT1, SRC, and MAPK1). Molecular docking studies further confirmed the strong binding ability between HYD and these core targets. In cell experiments, we observed that HYD enhanced glucose uptake and suppressed gluconeogenesis in HepG2 cells and C2C12 cells. This resulted in an improvement in glucose metabolism, potentially through the regulation of the PI3K-Akt pathway. Conclusions This study provides valuable insights into the pharmacological effects of HYD on diabetes mellitus, suggesting its potential as a promising treatment option for the disease.

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“…It is known with the vernacular name of "mosquera", the exudate latex of the stem bark is yellow, and it is used to eliminate warts and to treat wounds, sores, and ulcers [34]. The diabetes is one of the major health problems in Ecuador [35,36] where the people commonly use medicinal plants to control this metabolic disease. In addition, finding new antibacterial agents is a big issue in medicinal chemistry because increasing resistance to antibiotic agents that are currently in use.…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents of Croton thurifer Kunth as α-Glucosidase Inhibitors

Morocho¹,

Sarango²,

Cruz-Erazo³

et al. 2019

Rec.Nat.Prod.

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Phytochemical investigation of Croton thurifer, collected in Loja-Ecuador, led to the isolation of seven known compounds identified as: (3R, 20S) -3-palmitate-20-hydroxydammar-24-ene (1); (3R, 20S)-3acetoxy-20-hydroxydammar-24-ene (2); trans-phytol (3); vomifoliol (4); β-sitosterol (5); trans-tiliroside (6) and sparsifol (7). The structures of the isolated compounds were determined by NMR, MS, as well as by comparison with literature data. The hypoglycemic activity of the crude extracts and isolated compounds was assessed by their ability to inhibit α-glucosidase activity. The hexane and methanol extracts did not show any inhibitory activity on α-glucosidase, while the ethyl acetate extract (EtOAc) showed very low inhibitory activity with IC50= 1.77 mg/mL. Two of the seven isolated compounds exhibited good inhibitory activity with IC50 values much higher than acarbose (377 μg/mL). trans-tiliroside was the compound with the highest inhibitory activity (IC50 = 114.85 μg/mL), while (3R, 20S)-3-Acetoxy-20-hydroxydammar-24-ene had moderate inhibitory activity (IC50=292.87). Trans-tiliroside exherted a non-competitive inhibition with Km values between 368 and 358 μM and Vmax value from 695 and 325 nM/min for unhibited and inhibited reaction, respectively and a Ki of 163,6 μM.

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Main Constituents and Antidiabetic Properties of Otholobium mexicanum

Cited by 5 publications

References 21 publications

Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

Integrated investigation and discovery of therapeutic targets for 3-hydroxybakuchiol against diabetes based on molecular docking studies and cell experiments

Chemical Constituents of Croton thurifer Kunth as α-Glucosidase Inhibitors

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