Main Aspects of Dependence of Metabolic Syndrome and Male Infertility (Literature Review)

Suprunenko, S. M.

doi:10.29254/2077-4214-2020-3-157-35-40

Cited by 2 publications

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“…By most definitions, obesity and IR/DM-2 are key components of MS. A decrease in testosterone levels (androgen deficiency) is a new pathogenetically important component of MS in men, since the frequency and severity of androgen deficiency are directly proportional to obesity and impaired carbohydrate metabolism. (Korylchuk, 2019;Suprunenko, 2020). The main etiological factors of the metabolic syndrome are genetic predisposition, excessive intake of fats and lack of exercise .…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of the physical therapy program for patients with metabolic syndrome based on the study of the dynamics of the functional state of the autonomic nervous system and hemodynamic parameters

Kalmykova

Kalmykov

2023

Fìz. reabìl. rekreac.-ozdor. tehnol.

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Purpose: determination of the influence of the physical therapy program on the dynamics of blood pressure, heart rate and vegetative Kerdo index in patients with metabolic syndrome. Material & Methods: the study was conducted on the basis of the Municipal institution of health care "Kharkiv City Hospital No. 3". 28 young women were under observation, randomly divided into two groups: the main group (MG) – 14 patients and the control group (CG) – 14 patients. The mean age of patients in the MG was 31,49±0,71 years, in the CG – 31,06±0,57 years. The patients of the main group underwent rehabilitation measures according to the author's program of physical therapy, which included a hypocaloric diet with a lipid-lowering orientation (lipid-lowering diet No. 1), the basic principles of which are developed by the American Heart Association, therapeutic massage for patients with alimentary-constitutional obesity; kinesitherapy using elements of sports-oriented aerobics and special physical exercises based on Pilates gymnastics using fitballs and expanders; dosed walking in combination with breathing exercises, taking into account the activity of the autonomic nervous system, for patients in the control group – according to the program used for metabolic syndrome in the indicated medical institution. To identify the effectiveness of the author's program, a comparison was made of heart rate, arterial tonometry, vegetative Kerdo index (V.I.) at the beginning and end of the study. Results: in the determination and analysis of blood pressure, heart rate and vegetative Kerdo index during the second study, we noted the normalization of heart rate, SBP, DBP in women of the main group (р>0,05), in the control group, the dynamics of DBP was statistically insignificant (р>0,05). In women of the main group, the heart rate during the second examination compared with the primary one decreased by 19,8%, the SBP level decreased by 9,1%, the DBP level decreased by 11,0%. In CG patients, the heart rate during the second study decreased by 8.8% compared to the primary one, the SBP level decreased by 5,2%, the DBP level decreased by 3,9% (р>0,05). Conclusions: comparison of the obtained results of the study showed the normalization of hemodynamic parameters and the tone of the autonomic nervous system, there was also a tendency towards balance of the sympathetic and parasympathetic divisions of the ANS in patients of the main group, in the physical rehabilitation of which therapeutic exercises were applied with the use of regulated breathing exercises, taking into account the tone of the sympathetic or parasympathetic divisions of the autonomic nervous system, which helps to improve the quality of life of patients with metabolic syndrome.

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Section: Introductionmentioning

confidence: 99%

The effectiveness of the physical therapy program for patients with metabolic syndrome based on the study of the dynamics of the functional state of the autonomic nervous system and hemodynamic parameters

Kalmykova

Kalmykov

2023

Fìz. reabìl. rekreac.-ozdor. tehnol.

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“…Вченими доведено, що андрологічна складова безплідних шлюбів в Україні становить 47,5%, при цьому найбільш вагомою причиною порушень генеративної функції є розвиток інфекційно-запальних процесів статевих органів, що діагностуються у 35,5% випадків [8]. Розлади репродуктивного здоров'я чоловіків також можуть бути обумовлені впливом інших факторів, а саме: нервово-психічним напруженням, вродженою патологією, ендокринними розладами, дією шкідливих факторів зовнішнього середовища, шкідливими звичками, екзогенною та ендогенною інтоксикацією тощо [5,10]. За останніми даними, пандемія COVID-19 також була включена до переліку факторів, що потенційно негативно впливають на фертильність [6].…”

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Spermogram and Hormone Profile Indicators Analysis Among Patients with Different Types of Male Infertility Depending on Antioxidant System Status

Olexii

Fedir

Olexander

et al. 2021

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The objective: evaluation of interrelation between indicators of spermoplasm, androgen profile and malondialdehyde (MDA) content in spermoplasm among men with different types of male infertility. Materials and methods. 39 men at the age ranged from 24 to 45 years with different degrees of spermatogenesis and hormonal profile disorders were examined; MDA content in spermoplasm among patients who were diagnosed with «secretory male infertility» (n=7) was 23.3-38.3 μm/l, diagnosed with «excretory-toxic male infertility» (n=32) – 17.3–53.0 μm/l, therefore this group was divided into subgroups: 1 – up to 19.9 μm/l; 2 – within 20.6–29.1 mcm/l; 3 – more than 30.0 μm/l. In spermoplasm of the control group (donor sperm), this indicator was within 20.8–24.9 μm/l range. Interrelation assessment between the investigated indicators was carried out by methods of variational and correlation analysis using non-parametric statistics. Results. Studies results showed that the number of white blood cells in patients’ sperm of all groups exceeded the standard, wherein a close connection between this indicator and MDA content in spermoplasm (r=0.99 and r=0.48, with α≤0,05) was established. In groups where lipid peroxidation activity was significantly higher than control indicators, the highest percentage of men (more than 40%) with reduced sperm activity and viability was detected. Free testosterone decrease was observed among almost 70-90% of examined men, while the most significant changes were found among patients who were diagnosed with «excretory-toxic male infertility» and high MDA content in spermoplasm. A close positive connection between MDA content and sperm dilution time (r=0.79; α≤0,05) was established in group of patients who were diagnosed with «secretory male infertility», as well as the level of LH in blood (r=0.74; α≤0,05); among patients who were diagnosed with «excretory-toxic male infertility» the status of the pro-antioxidant system, which is characterized as «oxidative stress» (third subgroup), a reliable negative association was found between MDA level in spermoplasm and the level of FSH in blood (r=– 0.75; α≤0,05). Conclusions. A relation between high MDA level in spermoplasm and increase of white blood cells number in sperm was established, as well as a decrease of sperm motor activity and content of bioavailable testosterone in blood.

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Main Aspects of Dependence of Metabolic Syndrome and Male Infertility (Literature Review)

Cited by 2 publications

References 50 publications

The effectiveness of the physical therapy program for patients with metabolic syndrome based on the study of the dynamics of the functional state of the autonomic nervous system and hemodynamic parameters

The effectiveness of the physical therapy program for patients with metabolic syndrome based on the study of the dynamics of the functional state of the autonomic nervous system and hemodynamic parameters

Spermogram and Hormone Profile Indicators Analysis Among Patients with Different Types of Male Infertility Depending on Antioxidant System Status

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