Main Approaches to Controlled Protein Degradation in the Cell

Kapitonova, M. A.; Shadrina, Olga; Korolev, S. P.; Gottikh, Marina

doi:10.1134/s0026893321030067

Cited by 3 publications

(2 citation statements)

References 85 publications

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“…Transfer of Ub to substrate proteins typically requires a third enzyme—ubiquitin ligase that catalyzes the formation of an isopeptide bond between a lysine residue of the substrate protein and the C-terminal glycine residue of Ub (E3). Depending on E3, substrate ubiquitination occurs either by direct transfer of Ub from E2 or through the intermediate formation of a thioester bond between Ub and E3 [ 24 , 25 ]. Repeating these steps results in polyubiquitination of the substrate protein.…”

Section: Factors Affecting Integrase Stabilitymentioning

confidence: 99%

Complex Relationships between HIV-1 Integrase and Its Cellular Partners

Rozina

Anisenko

Kikhai

et al. 2022

IJMS

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RNA viruses, in pursuit of genome miniaturization, tend to employ cellular proteins to facilitate their replication. HIV-1, one of the most well-studied retroviruses, is not an exception. There is numerous evidence that the exploitation of cellular machinery relies on nucleic acid-protein and protein-protein interactions. Apart from Vpr, Vif, and Nef proteins that are known to regulate cellular functioning via interaction with cell components, another viral protein, integrase, appears to be crucial for proper virus-cell dialog at different stages of the viral life cycle. The goal of this review is to summarize and systematize existing data on known cellular partners of HIV-1 integrase and their role in the HIV-1 life cycle.

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Section: Factors Affecting Integrase Stabilitymentioning

confidence: 99%

Complex Relationships between HIV-1 Integrase and Its Cellular Partners

Rozina

Anisenko

Kikhai

et al. 2022

IJMS

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“…4 Once proteins have fulfilled their functions, or when errors or injuries arise during the processes of synthesis, folding, and transportation, it becomes necessary for them to be degraded and cleared in time to maintain the stability of the intracellular environment. 5,6 In human cells, there are two main sites for protein degradation, namely lysosomes and proteasomes. 7,8 Among them, proteasome-mediated protein degradation is the primary pathway, which requires the participation of the ubiquitin-proteasome system (UPS).…”

Section: Introductionmentioning

confidence: 99%

In silico screening and computational evaluation of novel promising USP14 inhibitors targeting the palm–thumb pocket

Wang¹,

Tong²,

Zhang³

et al. 2023

Phys. Chem. Chem. Phys.

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Review of Small Molecule Anticancer NF-κB Inhibitors

Кзыргалин

Yamidanov

Nazmieva

et al. 2023

Kreativnaâ hirurgiâ i onkologiâ

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Cancer is one of the most common diseases in the world. Th e transcription factor NF-κB plays a key role in various physiological processes including immune response, cell proliferation, cell apoptosis and inflammation. Due to participation of NF-kappa B signaling pathways in carcinogenesis, angiogenesis, and tumor resistance to chemo- and radiotherapy, the factor is considered to be the ideal target for pharmacological treatment of cancer. Th e paper presents a literature review of the RSCI, PubMed, Scopus, Web of Science, Chemical Abstracts NCCN databases and other open access data. The carcinogenesis inhibitors were selected from all NF-κB inhibitors found. Inhibitors with antitumor activity of analytical interest include Bruton tyrosine kinase (BTK) inhibitors, cellular inhibitors of apoptosis proteins (c-IAP), proteasome inhibitors, and one inhibitor of NF-κB translocation to the nucleus. Th e authors analyzed products of diff erent development stages with recorded antitumor activity to varying degrees. NF-κB inhibitors are promising drug candidates, but since NF-κB is involved in most biological processes and the broad spectrum of action can cause side eff ects, the selective action of these compounds is to be explored.

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Main Approaches to Controlled Protein Degradation in the Cell

Cited by 3 publications

References 85 publications

Complex Relationships between HIV-1 Integrase and Its Cellular Partners

Complex Relationships between HIV-1 Integrase and Its Cellular Partners

In silico screening and computational evaluation of novel promising USP14 inhibitors targeting the palm–thumb pocket

Review of Small Molecule Anticancer NF-κB Inhibitors

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