Magnusiomyces capitatus Peritonitis in a Child With Acute Lymphocytic Leukemia as a Breakthrough Infection During Caspofungin Therapy

Barış, Ayşe; Gencer, Hasim; Dalgıç, Nazan; Şık, Güntülü; Özakkaş, Fatma; Aktaş, Elif

doi:10.1097/inf.0000000000001720

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…To our knowledge, this is the first reported case of S. capitata peritonitis with a fatal outcome in a patient without neutropenia or associated malignancy. Bariş et al reported a case of peritonitis due to S. capitat a in a child with acute lymphocytic leukemia during caspofungin therapy; the patient’s condition was improved after antifungal treatment adjustment [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

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Saprochaete Capitata Peritonitis in a Non-neutropenic Patient Without Underlying Malignancies: A Case Report

Rahali,

Bounani,

Babokh

et al. 2023

Cureus

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Saprochaete capitata ( S. capitata ) is an opportunistic arthroconidial yeast-like fungus causing invasive infections in immunocompromised patients, mainly those with hematological malignancies and severe neutropenia. However, infections due to S. capitata are extremely rare in immunocompetent and non-neutropenic patients. Saprochaete spp. are microscopically characterized by arthroconidia with hyaline-septated hyphae. S. capitata is known to be intrinsically resistant to echinocandins and highly resistant to fluconazole. It is suggested to use amphotericin B or voriconazole (in monotherapy or in combination) as the gold standard treatment for S. capitata systemic infections. We report a rare case of S. capitata peritonitis with fatal outcome in a non-neutropenic patient without underlying malignancies. This case report highlights the value of direct microscopic examination and stained smears in a prompt preliminary diagnosis of S. capitata invasive fungal infections. We also aim to emphasize the importance of early initiation of appropriate antifungal treatment in patients with S. capitata systemic infections, thus improving their therapeutic outcome.

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Section: Discussionmentioning

confidence: 99%

“…are urease negativity of Saprochaete spp. and its ability to grow on Sabouraud dextrose agar with cycloheximide [ 3 , 10 ]. Microscopically, Saprochaete spp.…”

Section: Discussionmentioning

confidence: 99%

Saprochaete Capitata Peritonitis in a Non-neutropenic Patient Without Underlying Malignancies: A Case Report

Rahali,

Bounani,

Babokh

et al. 2023

Cureus

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“…Consequently, precise and prompt diagnosis, as well as treatment, emerge as pivotal challenges [27]. As susceptibility breakpoints have not yet been established for M. capitatus [28], we employed breakpoints recommended by the CLSI M27-A3 document for other related yeast species to overcome this limitation. Based on the in vitro susceptibility results, the highest MICs were observed for fluconazole and caspofungin.…”

Section: Mortalitymentioning

confidence: 99%

The first case of isolation of Magnusiomyces capitatus from the oral cavity of an addicted patient

Ghojoghi,

Khodavaisy,

Zarei Mahmoudabadi

et al. 2024

J Infect Dev Ctries

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Magnusiomyces capitatus (M. capitatus) is an emerging opportunistic yeast, rarely found as a causal agent of invasive fungal infection. In this study, we report a 31-year-old man infected with M. capitatus in the oral cavity, with a history of heroin and amphetamine abuse. M. capitatus was isolated through culture and microscopic analysis and identified by PCR amplification of the ITS DNA region. Based on the in vitro antifungal susceptibility test, the lowest MICs for M. capitatus were recorded for nystatin, itraconazole, and amphotericin, while higher MICs were observed for caspofungin and fluconazole. Treatment with nystatin successfully eliminated M. capitatus and relieved the clinical symptoms. This study presents the first case of M. capitatus in a patient with substance use disorder, manifesting as a plaque-like ulcer in the oral cavity.

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“…In this review, 82% (61/74) of the publications reported peritoneal dialysis-related peritonitis. When data were available, other risk factors for peritonitis were underlying neoplasia [118], gastric and duodenal ulcer perforation [119], recent digestive surgery [120][121][122][123][124], severe immunosuppression [125,126], and pancreatitis [127]. In some cases, infection of the peritoneum, as well as other unusual infection sites including the biliary tract (9 publications), gastric tract (12 publications), and spleen (19 publications), may also be a secondary condition to the haematogenous dissemination of yeasts [128].…”

Section: Digestive Systemmentioning

confidence: 99%

A Repertoire of the Less Common Clinical Yeasts

Menu,

Filori,

Dufour

et al. 2023

JoF

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Invasive fungal diseases are a public health problem. They affect a constantly increasing number of at-risk patients, and their incidence has risen in recent years. These opportunistic infections are mainly due to Candida sp. but less common or rare yeast infections should not be underestimated. These so-called “less common” yeasts include Ascomycota of the genera Candida (excluding the five major Candida species), Magnusiomyces/Saprochaete, Malassezia, and Saccharomyces, and Basidiomycota of the genera Cryptococcus (excluding the Cryptococcus neoformans/gattii complex members), Rhodotorula, and Trichosporon. The aim of this review is to (i) inventory the less common yeasts isolated in humans, (ii) provide details regarding the specific anatomical locations where they have been detected and the clinical characteristics of the resulting infections, and (iii) provide an update on yeast taxonomy. Of the total of 239,890 fungal taxa and their associated synonyms sourced from the MycoBank and NCBI Taxonomy databases, we successfully identified 192 yeasts, including 127 Ascomycota and 65 Basidiomycota. This repertoire allows us to highlight rare yeasts and their tropism for certain anatomical sites and will provide an additional tool for diagnostic management.

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Magnusiomyces capitatus Peritonitis in a Child With Acute Lymphocytic Leukemia as a Breakthrough Infection During Caspofungin Therapy

Cited by 6 publications

References 7 publications

Saprochaete Capitata Peritonitis in a Non-neutropenic Patient Without Underlying Malignancies: A Case Report

Saprochaete Capitata Peritonitis in a Non-neutropenic Patient Without Underlying Malignancies: A Case Report

The first case of isolation of Magnusiomyces capitatus from the oral cavity of an addicted patient

A Repertoire of the Less Common Clinical Yeasts

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