Magnolol promotes thermogenesis and attenuates oxidative stress in 3T3-L1 adipocytes

Parray, Hilal Ahmad; Lone, Jameel; Park, Jong Pil; Choi, Jang Won; Yun, Jong Won

doi:10.1016/j.nut.2018.01.017

Cited by 38 publications

(29 citation statements)

References 54 publications

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“…In this context, extracts from the bark of Magnolia species, such as M. officinalis and M. obovata, are widely used in traditional Korean, Chinese, and Japanese herbal medicine for the treatment of gastrointestinal disorders, anxiety, and allergies [2]. Other reported actions include anti-inflammatory [3][4][5], antimicrobial [6][7][8], anti-oxidative [9][10][11], neuroprotective [12], anti-thrombotic [13], and anti-depressant [14,15] properties.…”

Section: Introductionmentioning

confidence: 99%

Magnolol and Honokiol: Two Natural Compounds with Similar Chemical Structure but Different Physicochemical and Stability Properties

et al. 2021

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Magnolia spp. extracts are known for their use in traditional Korean, Chinese, and Japanese medicine in the treatment of gastrointestinal disorders, anxiety, and allergies. Among their main components with pharmacological activity, the most relevant are magnolol and honokiol, which also show antitumoral activity. The objectives of this work were to study some physicochemical properties of both substances and their stability under different conditions of temperature, pH, and oxidation. Additionally, liposomes of honokiol (the least stable compound) were formulated and characterized. Both compounds showed pH-dependent solubility, with different solubility–pH profiles. Magnolol showed a lower solubility than honokiol at acidic pH values, but a higher solubility at alkaline pH values. The partition coefficients were similar and relatively high for both compounds (log Po/w ≈ 4.5), indicating their lipophilic nature. Honokiol was less stable than magnolol, mainly at neutral and basic pH values. To improve the poor stability of honokiol, it was suitably loaded in liposomes. The obtained liposomes were small in size (175 nm), homogeneous (polydispersity index = 0.17), highly negatively charged (−11 mV), and able to incorporate high amounts of honokiol (entrapment efficiency = 93.4%). The encapsulation of honokiol in liposomes increased its stability only at alkaline pH values.

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Section: Introductionmentioning

confidence: 99%

Magnolol and Honokiol: Two Natural Compounds with Similar Chemical Structure but Different Physicochemical and Stability Properties

et al. 2021

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“…Increased oxidative stress contributes to the development of obesity-related metabolic disorders. Magnolol has been demonstrated to decrease ROS production, upregulate the expression of UCP1, Cd137, Prdm16, Cidea, Tbx1, PGC-1 α , CPT1, ACSL1, SIRT1, and PLIN, and downregulate the expression of FAS and SREBP1, resulting in browning of 3T3-L1 adipocytes, enhancing lipolysis and thermogenesis, and repressing oxidative stress through activation of AMP-activated protein kinase (AMPK), PPAR γ , and protein kinase A (PKA) signaling pathways [7] (Table 1). Acrolein, a neurotoxin, can induce neurodegenerative disorders through inducing oxidative stress and activating MEK/ERK signaling and mitochondrial caspases, leading to apoptosis in neuroblastoma SH-5Y5Y cells.…”

Section: Antioxidative Activitymentioning

confidence: 99%

“…Both magnolol and honokiol are isolated from the stem bark of a traditional Chinese herbal medicine Magnolia officinalis , which has been used for management of nervous disturbance, abdominal distention or disorders, gastrointestinal food stagnancy, and coughing and dyspnea [1]. Magnolol has showed a wide spectrum of beneficial activities, including anti-inflammation [2, 3], antimicroorganism [4, 5], antioxidation [6, 7], antiangiogenesis [8, 9], anticancer [10–12], neuroprotection [13, 14], cardiovascular protection [15, 16], and lipolysis activities [17, 18]. However, there are still some differences between magnolol and honokiol in safety and toxicology, which have been reviewed by Sarrica et al (2018)[19].…”

Section: Introductionmentioning

confidence: 99%

Insights on the Multifunctional Activities of Magnolol

Zhang

Chen

Huang

et al. 2019

BioMed Research International

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Over years, various biological constituents are isolated from Traditional Chinese Medicine and confirmed to show multifunctional activities. Magnolol, a hydroxylated biphenyl natural compound isolated from Magnolia officinalis, has been extensively documented and shows a range of biological activities. Many signaling pathways include, but are not limited to, NF-κB/MAPK, Nrf2/HO-1, and PI3K/Akt pathways, which are implicated in the biological functions mediated by magnolol. Thus, magnolol is considered as a promising therapeutic agent for clinic research. However, the low water solubility, the low bioavailability, and the rapid metabolism of magnolol dramatically limit its clinical application. In this review, we will comprehensively discuss the last five-year progress of the biological activities of magnolol, including anti-inflammatory, antimicroorganism, antioxidative, anticancer, neuroprotective, cardiovascular protection, metabolism regulation, and ion-mediating activity.

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“…In addition, it has been described that long-term supplementation of magnolol (17 mg/kg BW per day for 16 weeks) ameliorates body fat accumulation, insulin resistance, and adipose inflammation in HFD fed male C57BL/6J mice [125]. Moreover, regarding the thermogenic or browning effect in the adipocytes, Parray et al [126] described that 3T3-L1 adipocytes treated with 5–20 µM of magnolol during differentiation displayed a dose-dependent increase in the protein level UCP-1, PGC-1α, PRMD16, and PPARγ. The addition of 20 µM of magnolol in the presence of a 50 nM triiodothyronine with 1 µM rosiglitazone from day six to eight of differentiation in 3T3-L1 cells increased the expression of specific browning markers such as Ucp-1 , Pgc-1α , Prmd16 , Cd137 , Tbx1 , and Cidea .…”

Section: Food Compounds Related To the Browning Processmentioning

confidence: 99%

miRNAs and Novel Food Compounds Related to the Browning Process

Lorente‐Cebrián

Herrera

Milagro

et al. 2019

IJMS

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Obesity prevalence is rapidly increasing worldwide. With the discovery of brown adipose tissue (BAT) in adult humans, BAT activation has emerged as a potential strategy for increasing energy expenditure. Recently, the presence of a third type of fat, referred to as beige or brite (brown in white), has been recognized to be present in certain kinds of white adipose tissue (WAT) depots. It has been suggested that WAT can undergo the process of browning in response to stimuli that induce and enhance the expression of thermogenesis: a metabolic feature typically associated with BAT. MicroRNAs (miRNAs) are small transcriptional regulators that control gene expression in a variety of tissues, including WAT and BAT. Likewise, it was shown that several food compounds could influence miRNAs associated with browning, thus, potentially contributing to the management of excessive adipose tissue accumulation (obesity) through specific nutritional and dietetic approaches. Therefore, this has created significant excitement towards the development of a promising dietary strategy to promote browning/beiging in WAT to potentially contribute to combat the growing epidemic of obesity. For this reason, we summarize the current knowledge about miRNAs and food compounds that could be applied in promoting adipose browning, as well as the cellular mechanisms involved.

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Magnolol promotes thermogenesis and attenuates oxidative stress in 3T3-L1 adipocytes

Cited by 38 publications

References 54 publications

Magnolol and Honokiol: Two Natural Compounds with Similar Chemical Structure but Different Physicochemical and Stability Properties

Magnolol and Honokiol: Two Natural Compounds with Similar Chemical Structure but Different Physicochemical and Stability Properties

Insights on the Multifunctional Activities of Magnolol

miRNAs and Novel Food Compounds Related to the Browning Process

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