Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells

Chuang, Tzu Chao; Hsu, Shih Chung; Cheng, Yi Ting; Shao, Wei; Wu, Kuo-Hui; Fang, Guan; Ou, Chien Chih; Wang, Vinchi

doi:10.1016/j.canlet.2011.06.007

Cited by 38 publications

(48 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known that VEGF and HIF-1 are the downstream targets of PI3 K/AKT/mTOR pathway. The phosphorylation of AKT and mTOR is very remarkable events in angiogenesis [19]. They were evaluated by the western blot in hypoxic and normoxic conditions.…”

Section: Anti-angiogenesis Evect Of Ry10-4 On Zebrawsh Modelmentioning

confidence: 99%

RY10-4, a novel anti-tumor compound, exhibited its anti-angiogenesis activity by down-regulation of the HIF-1α and inhibition phosphorylation of AKT and mTOR

Liu

Yuan

Xue-nong

et al. 2012

Cancer Chemother Pharmacol

View full text Add to dashboard Cite

show abstract

Section: Anti-angiogenesis Evect Of Ry10-4 On Zebrawsh Modelmentioning

confidence: 99%

RY10-4, a novel anti-tumor compound, exhibited its anti-angiogenesis activity by down-regulation of the HIF-1α and inhibition phosphorylation of AKT and mTOR

Liu

Yuan

Xue-nong

et al. 2012

Cancer Chemother Pharmacol

View full text Add to dashboard Cite

show abstract

“…As a result, there has been an increasing amount of research interest in natural products and their bioactive effects, many of which have been used in traditional herbal medicine (4)(5)(6). Magnolol is a lignan found in the roots and bark of the magnolia tree Magnolia officinalis and has been shown to have anticancer effects in human cells in vitro and in vivo (7)(8)(9)(10)(11)(12)(13)(14)(15). Those studies performed in vivo suggest that magnolol remains active when administered at a sufficient oral dosage.…”

Section: Introductionmentioning

confidence: 96%

Magnolol Causes Alterations in the Cell Cycle in Androgen Insensitive Human Prostate Cancer CellsIn Vitroby Affecting Expression of Key Cell Cycle Regulatory Proteins

McKeown

McDougall

Catalli³

et al. 2014

Nutrition and Cancer

View full text Add to dashboard Cite

Prostate cancer, one of the most common cancers in the Western world, affects many men worldwide. This study investigated the effects of magnolol, a compound found in the roots and bark of the magnolia tree Magnolia officinalis, on the behavior of 2 androgen insensitive human prostate cancer cell lines, DU145 and PC3, in vitro. Magnolol, in a 24-h exposure at 40 and 80 μM, was found to be cytotoxic to cells. Magnolol also affected cell cycle progression of DU145 and PC3 cells, resulting in alterations to the cell cycle and subsequently decreasing the proportion of cells entering the G2/M-phase of the cell cycle. Magnolol inhibited the expression of cell cycle regulatory proteins including cyclins A, B1, D1, and E, as well as CDK2 and CDK4. Protein expression levels of pRBp107 decreased and pRBp130 protein expression levels increased in response to magnolol exposure, whereas p16(INK4a), p21, and p27 protein expression levels were apparently unchanged post 24-h exposure. Magnolol exposure at 6 h did increase p27 protein expression levels. This study has demonstrated that magnolol can alter the behavior of androgen insensitive human prostate cancer cells in vitro and suggests that magnolol may have potential as a novel anti-prostate cancer agent.

show abstract

“…Magnolol, a bioactive compound extracted from Magnolia officinalis, elicits multiple pharmacological effects, such as antitumor, antidepressant, antioxidant, and anti-inflammatory properties [22,23]. Lots of evidence revealed that Magnolol can serve as a therapeutic agent in several cancer types, such as lung, prostate, colon, and breast cancers [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Novel histone deacetylase inhibitors derived from Magnolia officinalis significantly enhance TRAIL-induced apoptosis in non-small cell lung cancer

Liu

Tong

Xia

et al. 2016

Pharmacological Research

View full text Add to dashboard Cite

Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells

Cited by 38 publications

References 41 publications

RY10-4, a novel anti-tumor compound, exhibited its anti-angiogenesis activity by down-regulation of the HIF-1α and inhibition phosphorylation of AKT and mTOR

RY10-4, a novel anti-tumor compound, exhibited its anti-angiogenesis activity by down-regulation of the HIF-1α and inhibition phosphorylation of AKT and mTOR

Magnolol Causes Alterations in the Cell Cycle in Androgen Insensitive Human Prostate Cancer CellsIn Vitroby Affecting Expression of Key Cell Cycle Regulatory Proteins

Novel histone deacetylase inhibitors derived from Magnolia officinalis significantly enhance TRAIL-induced apoptosis in non-small cell lung cancer

Contact Info

Product

Resources

About