Magnolol attenuates inflammatory pain by inhibiting sodium currents in mouse dorsal root ganglion neurons

Zhang, Lulu; Qiu, Jie; Hong, Jiangru; Xu, Xixi; Zhang, Guangqin; Li, Guang

doi:10.1007/s10787-021-00809-8

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…Honokiol (hit): An entire review has been dedicated to the myriad mechanistic pathways modulated by Honokiol. [ 48 ] Among those that are known to be pain‐relevant are CXCR4 receptors, STAT3, mTOR, EGFR, NF‐κB, GABAaR, and NMDA, [ 49 ] as well as voltage‐gated sodium [ 50 ] and delayed‐rectifier potassium [ 51 , 52 ] channels. A small number of antinociception studies have already been carried out in rodent inflammatory pain models, suggesting that Honokiol may serve as an effective treatment for both allodynia and hyperalgesia.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic Screening of Prospective Analgesics Among FDA‐Approved Compounds using an iPSC‐Based Model of Acute and Chronic Inflammatory Nociception

Black,

Ghazal,

Lojek

et al. 2024

Advanced Science

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Classical target‐based drug screening is low‐throughput, largely subjective, and costly. Phenotypic screening based on in vitro models is increasingly being used to identify candidate compounds that modulate complex cell/tissue functions. Chronic inflammatory nociception, and subsequent chronic pain conditions, affect peripheral sensory neuron activity (e.g., firing of action potentials) through myriad pathways, and remain unaddressed in regard to effective, non‐addictive management/treatment options. Here, a chronic inflammatory nociception model is demonstrated based on induced pluripotent stem cell (iPSC) sensory neurons and glia, co‐cultured on microelectrode arrays (MEAs). iPSC sensory co‐cultures exhibit coordinated spontaneous extracellular action potential (EAP) firing, reaching a stable baseline after ≈27 days in vitro (DIV). Spontaneous and evoked EAP metrics are significantly modulated by 24‐h incubation with tumor necrosis factor‐alpha (TNF‐α), representing an inflammatory phenotype. Compared with positive controls (lidocaine), this model is identified as an “excellent” stand‐alone assay based on a modified Z’ assay quality metric. This model is then used to screen 15 cherry‐picked, off‐label, Food and Drug Administration (FDA)‐approved compounds; 10 of 15 are identified as “hits”. Both hits and “misses” are discussed in turn. In total, this data suggests that iPSC sensory co‐cultures on MEAs may represent a moderate‐to‐high‐throughput assay for drug discovery targeting inflammatory nociception.

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Section: Discussionmentioning

confidence: 99%

Phenotypic Screening of Prospective Analgesics Among FDA‐Approved Compounds using an iPSC‐Based Model of Acute and Chronic Inflammatory Nociception

Black,

Ghazal,

Lojek

et al. 2024

Advanced Science

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“…Magnolol in in vivo studies on animal models showed a protective effect in Parkinson's disease [65] and Alzheimer's disease [66], supported the processes of concentration and learning and improved memory [66,67], or revealed antidepressant activity [68,69]. It should also be emphasized that magnolol has a proven analgesic effect [70,71]. Due to numerous reports on the protective effect of magnolol on the nervous system, it can be assumed that this lignan may also have neuroprotective effects in the course of diabetes, but careful research in this area is required.…”

Section: Magnolol and Diabetic Neuropathymentioning

confidence: 98%

Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities—A Review

Szałabska-Rąpała

Borymska

Kaczmarczyk-Sedlak

2021

IJMS

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Diabetes mellitus is a chronic metabolic disease characterized by disturbances in carbohydrate, protein, and lipid metabolism, often accompanied by oxidative stress. Diabetes treatment is a complicated process in which, in addition to the standard pharmacological action, it is necessary to append a comprehensive approach. Introducing the aspect of non-pharmacological treatment of diabetes allows one to alleviate its many adverse complications. Therefore, it seems important to look for substances that, when included in the daily diet, can improve diabetic parameters. Magnolol, a polyphenolic compound found in magnolia bark, is known for its health-promoting activities and multidirectional beneficial effects on the body. Accordingly, the goal of this review is to systematize the available scientific literature on its beneficial effects on type 2 diabetes and its complications. Taking the above into consideration, the article collects data on the favorable effects of magnolol on parameters related to glycemia, lipid metabolism, or oxidative stress in the course of diabetes. After careful analysis of many scientific articles, it can be concluded that this lignan is a promising agent supporting the conventional therapies with antidiabetic drugs in order to manage diabetes and diabetes-related diseases.

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Honokiol alleviates monosodium urate-induced gouty pain by inhibiting voltage-gated proton channels in mice

Miao,

Yuan,

Zhang

et al. 2024

Inflammopharmacol

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Magnolol attenuates inflammatory pain by inhibiting sodium currents in mouse dorsal root ganglion neurons

Cited by 4 publications

References 37 publications

Phenotypic Screening of Prospective Analgesics Among FDA‐Approved Compounds using an iPSC‐Based Model of Acute and Chronic Inflammatory Nociception

Phenotypic Screening of Prospective Analgesics Among FDA‐Approved Compounds using an iPSC‐Based Model of Acute and Chronic Inflammatory Nociception

Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities—A Review

Honokiol alleviates monosodium urate-induced gouty pain by inhibiting voltage-gated proton channels in mice

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