Magnocellular neurosecretory neurons with ferritin-like immunoreactivity in the hypothalamic supraoptic and paraventricular nuclei of the rat

Tokunaga, Akira; Ono, Katsuhiko; Ono, Toshiro; Ogawa, Makoto

doi:10.1016/0006-8993(92)91522-g

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…It can act as an immuno-suppressor (Recalcati et al 2008) and as an oxygen free radical-mediated damage protectant (Orino et al 2001). Water deprivation causes enlargement of the cell bodies and increases the number of AVP-ferritin containing neurons (Tokunaga et al 1992). There are no data available about ferritin presence in di/di Brattleboro PVN and SON neurons.…”

Section: Son and Pvn Principal Osmoregulatory Neuropeptidesmentioning

confidence: 98%

“…Ferritin protein is found almost in all AVPimmunoreactive neurons of the rat PVN and SON (Tokunaga et al 1992). It is involved in the intracellular storage of iron, and it has been implicated in the pathogenesis of many diseases such as atherosclerosis, Parkinson's disease, Alzheimer disease, and restless legs syndrome (You and Wang 2005).…”

Section: Son and Pvn Principal Osmoregulatory Neuropeptidesmentioning

confidence: 99%

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Response of Substances Co-Expressed in Hypothalamic Magnocellular Neurons to Osmotic Challenges in Normal and Brattleboro Rats

et al. 2008

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The intention of this review is to emphasize the current knowledge about the extent and importance of the substances co-localized with magnocellular arginine vasopressin (AVP) and oxytocin (OXY) as potential candidates for the gradual clarification of their actual role in the regulation of hydromineral homeostasis. Maintenance of the body hydromineral balance depends on the coordinated action of principal biologically active compounds, AVP and OXY, synthesized in the hypothalamic supraoptic and paraventricular nuclei. However, on the regulation of water-salt balance, other substances, co-localized with the principal neuropetides, participate. These can be classified as (1) peptides co-localized with AVP or OXY with unambiguous osmotic function, including angiotensin II, apelin, corticotropin releasing hormone, and galanin and (2) peptides co-localized with AVP or OXY with an unknown role in osmotic regulation, including cholecystokinin, chromogranin/secretogranin, dynorphin, endothelin-1, enkephalin, ferritin protein, interleukin 6, kininogen, neurokinin B, neuropeptide Y, vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, TAFA5 protein, thyrotropin releasing hormone, tyrosine hydroxylase, and urocortin. In this brief review, also the responses of these substances to different hyperosmotic and hypoosmotic challenges are pointed out. Based on the literature data published recently, the functional implication of the majority of co-localized substances is still better understood in non-osmotic than osmotic functional circuits. Brattleboro strain of rats that does not express functional vasopressin was also included in this review. These animals suffer from chronic hypernatremia and hyperosmolality, accompanied by sustained increase in OXY mRNA in PVN and SON and OXY levels in plasma. They represent an important model of animals with constantly sustained osmolality, which in the future, will be utilizable for revealing the physiological importance of biologically active substances co-expressed with AVP and OXY, involved in the regulation of plasma osmolality.

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Section: Son and Pvn Principal Osmoregulatory Neuropeptidesmentioning

confidence: 98%

Section: Son and Pvn Principal Osmoregulatory Neuropeptidesmentioning

confidence: 99%

Response of Substances Co-Expressed in Hypothalamic Magnocellular Neurons to Osmotic Challenges in Normal and Brattleboro Rats

et al. 2008

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“…Intraneuronal iron not utilized in the respiratory chain is probably bound to ferritin. Ferritin has been immunohistochemically demonstrated in neurons of the neocortex of monkey (Connor et al, 1994), habenular nucleus of rat (Tokunaga et al, 19921, and mouse (Moos, 1995b), and in the hypothalamic paraventricular and supraoptic nucleus of rat (Tokunaga et al, 1992). Moreover, there is good evidence that ferritin occurs in microglial cells (Kaneko et al, 1989).…”

Section: The Dynamics Of Neuronal Uptake Of Iron: Role Of Transferrinmentioning

confidence: 99%

Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system

Moos¹

1996

J. Comp. Neurol.

153

100

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Iron is essential for a variety of intracellular functions. Accordingly, the transfer of iron from blood to brain is vital for normal brain function. In the CNS, the receptor for iron-transferrin is generally accepted to be located in endothelial cells, whereas its occurrence in other cell types is less well established. I have investigated the distribution of the transferrin receptor in the adult mouse central nervous system by immunohistochemistry by using a monoclonal antibody raised against the transferrin receptor protein. Immunoreactive cell types comprised brain capillary endothelial cells, excluding those of circumventricular organs, and choroid plexus epithelial cells. Moreover, transferrin receptor immunoreactivity was detected intraneuronally in several brain regions without access to peripheral blood. The immunoreactive cell bodies were mainly confined to the cerebral cortex, hippocampus, habenular nucleus, red nucleus, substantia nigra, pontine nuclei, reticular formation, several cranial nerve nuclei, deep cerebellar nuclei, and cerebellar cortex. Transferrin receptor immunoreactivity was not detected in astrocytes, oligodendrocytes, or microglial cells. The occurrence of transferrin receptors at brain-barrier sites, i.e., the brain endothelium and choroid plexus epithelium, and the presence of the receptors intraneuronally are in accordance with the generally held belief that iron is released from liver transferrin and transported through capillaries and the choroid plexus into the brain interstitium. Subsequently, iron may be linked to brain transferrin synthesized within oligodendrocytes and choroid plexus epithelial cells followed by a concomitant uptake of iron-transferrin in neurons expressing transferrin receptors. The clinical importance of the intraneuronal transferrin receptor expression is discussed.

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Iron is Responsible for Production of Reactive Oxygen Species Regulating Vasopressin Expression in the Mouse Paraventricular Nucleus

Hyeun

Kim

et al. 2019

Neurochem Res

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Magnocellular neurosecretory neurons with ferritin-like immunoreactivity in the hypothalamic supraoptic and paraventricular nuclei of the rat

Cited by 5 publications

References 14 publications

Response of Substances Co-Expressed in Hypothalamic Magnocellular Neurons to Osmotic Challenges in Normal and Brattleboro Rats

Response of Substances Co-Expressed in Hypothalamic Magnocellular Neurons to Osmotic Challenges in Normal and Brattleboro Rats

Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system

Iron is Responsible for Production of Reactive Oxygen Species Regulating Vasopressin Expression in the Mouse Paraventricular Nucleus

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