Magnitude and duration of acute-exercise intensity effects on symptoms of restless legs syndrome: a pilot study

Cederberg, Katie L.J.; Motl, Robert W.; Burnham, Tim

doi:10.1007/s41105-018-0158-6

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…In patients with mild symptoms, nonpharmacologic therapies may be sufficient. These include wearing sensible shoes, exercise and behavioral strategies, distraction through mental activities, reduced caffeine intake, and massage [58].…”

Section: Treatmentmentioning

confidence: 99%

Why Are Women Prone to Restless Legs Syndrome?

Seeman

2020

IJERPH

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Restless legs syndrome is a relatively common neurologic disorder considerably more prevalent in women than in men. It is characterized by an inactivity-induced, mostly nocturnal, uncomfortable sensation in the legs and an urge to move them to make the disagreeable sensation disappear. Some known genes contribute to this disorder and the same genes contribute to an overlapping condition—periodic leg movements that occur during sleep and result in insomnia. Dopamine and glutamate transmission in the central nervous system are involved in the pathophysiology, and an iron deficiency has been shown in region-specific areas of the brain. A review of the literature shows that pregnant women are at particular risk and that increased parity is a predisposing factor. Paradoxically, menopause increases the prevalence and severity of symptoms. This implies a complex role for reproductive hormones. It suggests that changes rather than absolute levels of estrogen may be responsible for the initiation of symptoms. Both iron (at relatively low levels in women) and estrogen (at relatively high oscillating levels in women) influence dopamine and glutamate transmission, which may help to explain women’s vulnerability to this condition. The syndrome is comorbid with several disorders (such as migraine, depression, and anxiety) to which women are particularly prone. This implies that the comorbid condition or its treatment, or both, contribute to the much higher prevalence in women than in men of restless legs syndrome.

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Section: Treatmentmentioning

confidence: 99%

Why Are Women Prone to Restless Legs Syndrome?

Seeman

2020

IJERPH

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“…Non-medical treatment includes physical activity ( 24 ), adequate nutritional diet ( 25 ), and cognitive behavioral therapy ( 26 , 27 ). With respect to the former, results depend on exercise routine (acute vs. chronic) and intensity (light vs. vigorous), with acute exercise, at either intensity, having a direct effect on RLS symptoms.…”

Section: Introductionmentioning

confidence: 99%

Behavioral sleep medicine—The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental disabilities and restless sleep

Silvestri

Ipsiroglu

2022

Front. Psychiatry

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In behavioral medicine, sleep disorders, insomnia in particular, may be considered comorbidities and precipitating factors to intellectual or developmental disabilities (IDD). Nevertheless, sleep alterations have often been neglected in favor of daytime features and symptoms, albeit simple behavioral nighttime observations may disclose hypermotor features that characterize restless sleep. The root of most hypermotor restlessness is linked to central iron deficiency. The latter is often exacerbated by vitamin D deficiency (VDD), which interferes with both dopaminergic and serotonergic mechanisms. In this way, an imbalance affecting daytime behavior and mood is created. Several sleep-related motor disorders such as bruxism, periodic and aperiodic leg movements, Restless Legs Syndrome (RLS), and Restless Sleep Disorder (RSD) are commonly seen in Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorders (ASD). However, they are rarely diagnosed and often overlooked in affected children and adolescents. As a result, not only are these disorders not adequately addressed therapeutically, but their symptoms may be worsened by the side-effects of drugs used to contain disruptive daytime behavior, such as antipsychotics and antidepressants. In children with IDDs, obesity, inactivity and metabolic effects of antipsychotics often lead to Sleep Disordered Breathing (SDB), which is currently understood as an inflammatory state leading to “hyperactive” lethargy and further alterations of the hypoxic chain and vitamin D levels. Endorsing simple routine blood tests, including inflammatory markers such as C-reactive protein, ferritin, transferrin, and vitamin D levels, may favorably complement caregiver observations and ambulatory sleep recordings, leading to a sleep disorder diagnosis and consequent therapy. In fact, the treatment of SDB, RLS, and RSD has been copiously demonstrated to favorably impact vigilance, behavior, social competence, and academic skills in healthy and, to a greater extent, in IDD children. Thus, consulting and deliberating the root causes of functional and categorical diagnoses within a clinical framework may engender a more precise diagnosis and further benefit pediatric daytime and nighttime management of hyperactive behaviors.

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Sleep and exercise

Kline

2019

Sleep and Health

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Magnitude and duration of acute-exercise intensity effects on symptoms of restless legs syndrome: a pilot study

Cited by 3 publications

References 35 publications

Why Are Women Prone to Restless Legs Syndrome?

Why Are Women Prone to Restless Legs Syndrome?

Behavioral sleep medicine—The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental disabilities and restless sleep

Sleep and exercise

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