Magnetoresistance of a p-type Semiconducting Diamond

Mitchell, Emma; Wedepohl, P T

doi:10.1088/0370-1301/70/5/410

Cited by 15 publications

(6 citation statements)

References 10 publications

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“…Furthermore, it may increase the risk of thrombus fragmentation with distal embolization of multiple smaller fragments, increasing the technical challenge of performing thrombectomy . Six randomized clinical trials have compared EVT with altepase with EVT without alteplase, finding small differences without evidence for the superiority of either approach . Pooled analysis of the first 4 trials found a nonsignificant approximate 1% increase in favorable modified Rankin scale (mRS) score at 90 days for EVT without alteplase, whereas conversely the last 2 trials, currently published in abstract form only, found a nonsignificant decrease in favorable mRS for EVT without alteplase.…”

Section: Introductionmentioning

confidence: 99%

“…Six randomized clinical trials have compared EVT with altepase with EVT without alteplase, finding small differences without evidence for the superiority of either approach . Pooled analysis of the first 4 trials found a nonsignificant approximate 1% increase in favorable modified Rankin scale (mRS) score at 90 days for EVT without alteplase, whereas conversely the last 2 trials, currently published in abstract form only, found a nonsignificant decrease in favorable mRS for EVT without alteplase. The most recent meta-analysis of all 6 trials found that using EVT without alteplase resulted in worse disability outcomes at 90 days, but this difference was not statistically significant .…”

Section: Introductionmentioning

confidence: 99%

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Outcomes After Endovascular Thrombectomy With or Without Alteplase in Routine Clinical Practice

Smith

Zerna

Solomon³

et al. 2022

JAMA Neurol

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IMPORTANCEThe effectiveness and safety of intravenous alteplase given before or concurrently with endovascular thrombectomy (EVT) is uncertain. Randomized clinical trials suggest there is little difference in outcomes but with only modest precision and insufficient power to analyze uncommon outcomes including symptomatic intracranial hemorrhage (sICH).OBJECTIVE To determine whether 8 prespecified outcomes are different in patients with acute ischemic stroke treated in routine clinical practice with EVT with alteplase compared with patients treated with EVT alone without alteplase. It was hypothesized that alteplase would be associated with higher risk of sICH. DESIGN, SETTING, AND PARTICIPANTSThis was an observational cohort study conducted from February 1, 2019, to June 30, 2020, that included adult patients with acute ischemic stroke treated with EVT within 6 hours of time last known well, after excluding patients without information on discharge destination and patients with in-hospital stroke. Participants were recruited from Get With The Guidelines-Stroke, a large nationwide registry of patients with acute ischemic stroke from 555 hospitals in the US. EXPOSURES Intravenous alteplase or no alteplase.MAIN OUTCOMES AND MEASURES Prespecified outcomes were discharge destination, independent ambulation at discharge, modified Rankin score at discharge, discharge mortality, cerebral reperfusion according to modified Thrombolysis in Cerebral Infarction grade, and sICH. RESULTS There were 15 832 patients treated with EVT (median [IQR] age, 72.0 [61.0-82.0] years; 7932 women [50.1%]); 10 548 (66.7%) received alteplase and 5284 (33.4%) did not. Patients treated with alteplase were younger, arrived via Emergency Medical Services sooner, were less likely to have certain comorbidities, including atrial fibrillation, hypertension, and diabetes, but had similar National Institutes of Health Stroke Severity (NIHSS) scores. Compared with patients who did not receive alteplase treatment, patients treated with alteplase were less likely to die (11.1% [1173 of 10 548 patients] vs 13.9% [734 of 5284 patients]; adjusted odds ratio [aOR] 0.83; 95% CI, 0.77-0.89; P < .001), more likely to have no major disability based on modified Rankin scale of 2 or less at discharge (28.5% [2415 of 8490 patients] vs 20.7% [894 of 4322 patients]; aOR, 1.36; 95% CI, 1.28-1.45; P < .001), and to have better reperfusion based on modified Thrombolysis in Cerebral Infarction grade 2b or greater (90.9% [8474 of 9318 patients] vs 88.0% [4140 of 4705 patients]; aOR, 1.39; 95% CI, 1.28-1.50; P < .001). However, alteplase treatment was associated with higher risk of sICH (6.5% [685 of 10 530 patients] vs 5.3% [279 of 5249 patients]; OR, 1.28; 95% CI, 1.16-1.42; P < .001). CONCLUSIONS AND RELEVANCEIn this observational cohort study of patients treated with EVT, intravenous alteplase treatment was associated with better in-hospital survival and functional outcomes but higher sICH risk after adjusting for other covariates.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Outcomes After Endovascular Thrombectomy With or Without Alteplase in Routine Clinical Practice

Smith

Zerna

Solomon³

et al. 2022

JAMA Neurol

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“…These have been connected with the breakdown of the ergodic assumption that is the basis for using ionization and dissociation rate formulae 37 . This rich literature on chaotic escape of electrons from atoms sets a precedent for delineating the changes in phase space structures due to saddle-node bifurcation that can be expected in open potential wells where the eigenvalues of the saddle equilibrium point depend on the well depth parameter 36,[38][39][40][41] .…”

Section: Introductionmentioning

confidence: 99%

Tilting and Squeezing: Phase Space Geometry of Hamiltonian Saddle-Node Bifurcation and its Influence on Chemical Reaction Dynamics

García-Garrido

Naik

Wiggins

2020

Int. J. Bifurcation Chaos

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In this article we present the influence of a Hamiltonian saddle-node bifurcation on the highdimensional phase space structures that mediate reaction dynamics. To achieve this goal, we identify the phase space invariant manifolds using Lagrangian descriptors, which is a trajectorybased diagnostic suitable for the construction of a complete "phase space tomography" by means of analyzing dynamics on low-dimensional slices. First, we build a Hamiltonian system with one degree-of-freedom (DoF) that models reaction, and study the effect of adding a parameter to the potential energy function that controls the depth of the well. Then, we extend this framework to a saddle-node bifurcation for a two DoF Hamiltonian, constructed by coupling a harmonic oscillator, i.e. a bath mode, to the other reactive DoF in the system. For this problem, we describe the phase space structures associated with the rank-1 saddle equilibrium point in the bottleneck region, which is a Normally Hyperbolic Invariant Manifold (NHIM) and its stable and unstable manifolds.Finally, we address the qualitative changes in the reaction dynamics of the Hamiltonian system due to changes in the well depth of the potential energy surface that gives rise to the saddle-node bifurcation.

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“…The general principle of the hydroxidemotive Cu loop mechanism was briefly outlined in the Croonian Lecture, delivered at the Royal Society, London, in May 1987 [19]. …”

Section: Introductionmentioning

confidence: 99%

A new redox loop formality involving metal‐catalysed hydroxide‐ion translocation A hypothetical Cu loop mechanism for cytochrome oxidase

Mitchell

1987

FEBS Letters

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A new hypothetical type of redox loop is described, which translocates hydroxide ions instead of protons. Conventional protonmotive redox loops use carriers of protons with electrons (e.g. QH2/Q systems) to couple electron transfer to the translocation of protons. The putative hydroxidemotive redox loop uses carriers ' of hydroxide ions against electrons (e.g. transition-metal centres) to couple electron transfer to the translocation of hydroxide ions. This simple idea leads to the proposal of a hydroxidemotive Cu loop mechanism that may possibly be applicable to the CUA or CuB centre of cytochrome oxidase, and might thus account for the coupling of electron transfer to net proton translocation in that osmoenzyme.

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Magnetoresistance of a p-type Semiconducting Diamond

Cited by 15 publications

References 10 publications

Outcomes After Endovascular Thrombectomy With or Without Alteplase in Routine Clinical Practice

Outcomes After Endovascular Thrombectomy With or Without Alteplase in Routine Clinical Practice

Tilting and Squeezing: Phase Space Geometry of Hamiltonian Saddle-Node Bifurcation and its Influence on Chemical Reaction Dynamics

A new redox loop formality involving metal‐catalysed hydroxide‐ion translocation A hypothetical Cu loop mechanism for cytochrome oxidase

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