Magnetoplasmonic nanoparticles for photothermal therapy

Abstract

In recent decades the applications of nanotechnology in the biomedical field have attracted a lot of attention. Magnetic and gold nanoparticles (MNPs and GNPs) are now of interest as selective tools for tumour treatment, due to their unique properties and biocompatibility. In this paper, superparamagnetic iron oxide nanoparticles (MNPs) decorated with gold nanoparticles (GNPs) have been prepared by means of an innovative synthesis process using tannic acid as the reducing agent. The as-obtained nanoplatforms were characterized in terms of size, morphology, structure, composition, magnetic response and plasmonic properties. The results revealed that hybrid nanoplatforms (magnetoplasmonic nanoparticles, MPNPs) composed of a magnetic core and an external GNP decoration, acting in synergy, have been developed. Biological tests were also performed on both healthy cells and cancer cells exposed to different nanoparticle concentrations, upon laser irradiation. GNPs grafted onto the surface of MNPs revealed the ability to convert the received light into thermal energy, which was selective in its detrimental effect on cancer cells.

Multifunctional Iron Oxide Magnetic Nanoparticles for Biomedical Applications: A Review

“…Moreover, the high stability of gold can prevent decomposition of the magnetic nanoparticles [82]. Recently, Multari et al synthesized hybrid nanoparticles of iron oxide decorated with gold (Fe 3 O 4 -Au) nanoparticles using tannic acid as a reducing agent [75]. The nanoparticles exhibited superparamagnetic behavior and a plasmonic peak at 560 nm, which is suitable for use in biomedical applications.…”

Magneto‐plasmonic heterodimers: Evaluation of different synthesis approaches

“…In synthesis 3a and 3b, Au(OH) 3 and TA solutions were added in sequence to the M-A NPs suspension and then heated at a 70 • C for 5 min under stirring, as reported in a previous paper. 23 In order to remove the unreacted reagents and the excess of unloaded GNPs, all the suspensions were washed and centrifuged in bi-distilled water five times for 20 min at 40 rpm and re-suspended in bi-distilled water.…”

“…Recently, the authors proposed a simple in situ reduction process of a soluble gold salt on (3‐Aminopropyl)triethoxysilane (APTES)‐functionalized magnetite NPs tailoring the molar ratio of the reagents, the pH and temperature of the process and avoiding the use of a specific reducing agent 22 . In an additional study published by the authors, hybrid gold‐magnetite nanoplatforms was obtained through a facile and reproducible synthesis method in which tannic acid (TA) was used as eco‐friendly reducing agent 23 . Another in situ reduction was proposed by Sood et al., in which gold‐coated magnetite NPs were synthesized by reduction of gold chloride onto the iron oxide NPs surface, using ascorbic acid as reducing and capping agent 20 .…”

“…22 In an additional study published by the authors, hybrid goldmagnetite nanoplatforms was obtained through a facile and reproducible synthesis method in which tannic acid (TA) was used as eco-friendly reducing agent. 23 Another in situ reduction was proposed by Sood et al, in which goldcoated magnetite NPs were synthesized by reduction of gold chloride onto the iron oxide NPs surface, using ascorbic acid as reducing and capping agent. 20 Dizaji et al, proposed an environmentally friendly procedure to generate hybrid NPs by reducing Ag or Au ions directly on the MNPs surface by using plant extracts as reducing and stabilizing agents.…”

Multifunctional Magneto-Plasmonic Fe3O4/Au Nanocomposites: Approaching Magnetophoretically-Enhanced Photothermal Therapy

“…Currently, there is a growing interest towards nanocomposites of iron oxide (Fe 3 O 4 ) and gold (Au), which combine magnetic and optical (plasmonic) properties inherent to both individual components; such magneto-plasmonic nanocomposites manifest high potential for targeted drug delivery and therapeutic applications [ 21 , 22 ]. In the case of complex magneto-plasmonic nanosystems, a magnetic field can be applied for their targeted delivery to cancer cells and increased uptake, allowing for enhanced photothermal effect through irradiation in the plasmonic absorption band, followed by efficient PTT demonstrated in vitro and in vivo [ 23 , 24 , 25 ]. On the other hand, the application of a magnetic field can induce interaction or aggregation of magneto-plasmonic nanoparticles that may cause changes in their optical properties [ 26 , 27 ].…”