Magnetoliposomes Incorporated in Peptide-Based Hydrogels: Towards Development of Magnetolipogels

Abstract

A major problem with magnetogels is the encapsulation of hydrophobic drugs. Magnetoliposomes not only provide these domains but also improve drug stability and avert the aggregation of the magnetic nanoparticles. In this work, two magnetoliposome architectures, solid and aqueous, were combined with supramolecular peptide-based hydrogels, which are of biomedical interest owing to their biocompatibility, easy tunability, and wide array of applications. This proof-of-concept was carried out through combination of magnetoliposomes (loaded with the model drug curcumin and the lipid probe Nile Red) with the hydrogels prior to pH triggered gelation, and fluorescence spectroscopy was used to assess the dynamics of the encapsulated molecules. These systems allow for the encapsulation of a wider array of drugs. Further, the local environment of the encapsulated molecules after gelation is unaffected by the used magnetoliposome architecture. This system design is promising for future developments on drug delivery as it provides a means to independently modify the components and adapt and optimize the design according to the required conditions.

Computational Modeling of Combination of Magnetic Hyperthermia and Temperature-Sensitive Liposome for Controlled Drug Release in Solid Tumor

“…The insertion of nanoparticles into liposomes is limited by the thickness of the membrane, which is approximately 3.4 nm thick, so the incorporation of larger MNPs into liposomes is a formidable task [24,25]. Furthermore, the encapsulation of drugs, stability of nanoparticle-embedded liposomes, and purification of non-encapsulated magnetic nanoparticles are the other major problems [26,27]. There exist many computational and experimental studies on applying stand-alone MHT [28][29][30][31] or magnetoliposomes [32][33][34][35][36] to solid tumors, but there is a lack of studies on the intravenous administration of TSLs in combination with MHT.…”

Radiation Crosslinked Smart Peptide Nanoparticles: A New Platform for Tumor Imaging

“…Nanoparticle-based contrast agents that can be applied to common biomedical imaging devices such as fluorescence imaging, magnetic resonance imaging (MRI), computerized tomography (CT), positron emission tomography (PET), and single-photon emission computerized tomography (SPECT) have also been developed [ 6 ]. Additionally, peptide-based magnetic nanoparticles with targeting and drug release properties through external magnetic fields have been reported [ 7 , 8 ]. Many functionalized nanoparticles respond to the internal environment, such as pH, redox, temperature, and enzymes [ 9 , 10 ].…”

Multilobed Magnetic Liposomes Enable Remotely Controlled Collection, Transport, and Delivery of Membrane-Soluble Cargos to Vesicles and Cells

“…This could be overcome by enlarging the content of the magnetic material, as is for example achieved by the creation of solid magnetoliposomes with magnetic cores in sizes between 100 and 200 nm. 45,46 Such dimensions, however, prevent renal elimination of the magnetic particles, which then have to be removed otherwise. 47 Moreover, the magnetic particles can compete with the functional cargo for space in the liposome.…”

“…In the case of traditional magnetoliposomes, due to steric limitations, the concentration of magnetic nanoparticles that can be encapsulated into the lumen or the membrane of simple liposomes is low, leading to a weak macroscopic magnetic response. This could be overcome by enlarging the content of the magnetic material, as is for example achieved by the creation of solid magnetoliposomes with magnetic cores in sizes between 100 and 200 nm. , Such dimensions, however, prevent renal elimination of the magnetic particles, which then have to be removed otherwise . Moreover, the magnetic particles can compete with the functional cargo for space in the liposome.…”