Magnetokardiographie (MKG): Technischer Fortschritt durch ein Vielkanal-SQUID-System. Klinische Anwendung bei Linkshypertrophie und WPW-Syndrom.

Moshage, Werner; Weikl, A; Abraham-Fuchs, K.; Schneider, Siegfried; Bachmann, K.; Reichenberger, Helmut

doi:10.1515/bmte.1989.34.s1.205

Cited by 3 publications

(3 citation statements)

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“…Informed consent for the study was obtained from all participated women before the procedures. The FMCG was recorded digitally by a single channel biomagnetometer (DC-SQUID model 601, USA) (Moshage et al, 1989;Nakaya and Mori, 1992;Achenbach and Moshage, 1993). The SQUID gradiometer operates at the low liquid helium temperature of 4°K on the basis of the Josephson effect of superconductivity (Josephson, 1962).…”

Section: Linear Analysis Of Fetal Magnetocardiogram Recordings In Normentioning

confidence: 99%

Linear analysis of fetal magnetocardiogram recordings in normal pregnancies at various gestational ages

Kotini

Anninos

Adamopoulos³

et al. 2001

Journal of Obstetrics and Gynaecology

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In this study we investigated the fetal magnetocardiogram recordings (FMCG) in 64 women, 21-30 years old, with single normal pregnancies and gestational ages 28-40 weeks. Spectral analysis was used to quantify heart rate variability and to identify the maturation of the autonomic nervous system. According to our results, there was an increase of the ratio LF/HF of the power spectrum, which reflects the maturation of the autonomous nervous system and also an increase in heart rate variability in the course of pregnancies, which was statistically significant (ANOVA test, P < 0.0005) comparing the R-R intervals of the number of cases in the four groups of 28-30, 37-40, 31-33 and 37-40 weeks of gestation. This study highlights some of the advantages of FMCG as a novel, non-invasive technique for obtaining useful clinical information.

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Section: Linear Analysis Of Fetal Magnetocardiogram Recordings In Normentioning

confidence: 99%

Linear analysis of fetal magnetocardiogram recordings in normal pregnancies at various gestational ages

Kotini

Anninos

Adamopoulos³

et al. 2001

Journal of Obstetrics and Gynaecology

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“…Second, it is less affected by conductivity variations caused by lungs, skin, and muscles compared with ECG. With the help of multichannel systems, 21 the entire thoracic magnetic field can be assessed in one measurement. 21 , 22 Data can be obtained at rest within 60 seconds of measurement time.…”

mentioning

confidence: 99%

“…With the help of multichannel systems, 21 the entire thoracic magnetic field can be assessed in one measurement. 21 , 22 Data can be obtained at rest within 60 seconds of measurement time.…”

mentioning

confidence: 99%

Application of Magnetocardiography to Screen for Inflammatory Cardiomyopathy and Monitor Treatment Response

Brala

Thevathasan

Grahl

et al. 2023

JAHA

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Background Inflammatory cardiomyopathy is one of the most common causes of sudden cardiac death in young adults. Diagnosis of inflammatory cardiomyopathy remains challenging, and better monitoring tools are needed. We present magnetocardiography as a method to diagnose myocardial inflammation and monitor treatment response. Methods and Results A total of 233 patients were enrolled, with a mean age of 45 (±18) years, and 105 (45%) were women. The primary analysis included 209 adult subjects, of whom 66 (32%) were diagnosed with inflammatory cardiomyopathy, 17 (8%) were diagnosed with cardiac amyloidosis, and 35 (17%) were diagnosed with other types of nonischemic cardiomyopathy; 91 (44%) did not have cardiomyopathy. The second analysis included 13 patients with inflammatory cardiomyopathy who underwent immunosuppressive therapy after baseline magnetocardiography measurement. Finally, diagnostic accuracy of magnetocardiography was tested in 3 independent cohorts (total n=23) and 1 patient, who developed vaccine‐related myocarditis. First, we identified a magnetocardiography vector to differentiate between patients with cardiomyopathy versus patients without cardiomyopathy (vector of ≥0.051; sensitivity, 0.59; specificity, 0.95; positive predictive value, 93%; and negative predictive value, 64%). All patients with inflammatory cardiomyopathy, including a patient with mRNA vaccine‐related myocarditis, had a magnetocardiography vector ≥0.051. Second, we evaluated the ability of the magnetocardiography vector to reflect treatment response. We observed a decrease of the pathologic magnetocardiography vector toward normal in all 13 patients who were clinically improving under immunosuppressive therapy. Magnetocardiography detected treatment response as early as day 7, whereas echocardiographic detection of treatment response occurred after 1 month. The magnetocardiography vector decreased from 0.10 at baseline to 0.07 within 7 days ( P =0.010) and to 0.03 within 30 days ( P <0.001). After 30 days, left ventricular ejection fraction improved from 42.2% at baseline to 53.8% ( P <0.001). Conclusions Magnetocardiography has the potential to be used for diagnostic screening and to monitor early treatment response. The method is valuable in inflammatory cardiomyopathy, where there is a major unmet need for early diagnosis and monitoring response to immunosuppressive therapy.

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Case report: Magnetocardiography as a potential method of therapy monitoring in amyloidosis

Golpour,

Suwalski,

Landmesser

et al. 2023

Front. Cardiovasc. Med.

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Amyloidosis is characterized by a disorder of protein conformation and metabolism, resulting in deposits of insoluble fibrils in various organs causing functional disturbances. Amyloidosis can also affect the heart. Cardiac amyloidosis tends to have a poor prognostic outcome if diagnosed at a late stage. Therefore, early diagnosis and initiation of therapy as well as monitoring of treatment response are crucial to improve outcomes and to learn more about its pathophysiology and clinical course. We present an 83-year-old woman with cardiac transthyretin amyloidosis (ATTR) who was treated with tafamidis. The patient significantly improved 18 months after initiation of therapy with regards to exercise capacity and quality of life. In addition to standard diagnostic methods, we used magnetocardiography (MCG) to monitor potential treatment response by detecting changes in the magnetic field of the heart. MCG is a non-invasive method that detects the cardiac magnetic field generated by electrical currents in the heart with high sensitivity. We have recently shown that this magnetic field changes in various types of cardiomyopathies may be used as a non-invasive screening tool. We determined previously that an MCG vector ≥0.052 was the optimal threshold to detect cardiac amyloidosis. The patient's MCG was measured at various time points during therapy. At the time of diagnosis, the patient's MCG vector was 0.052. After starting therapy, the MCG vector increased to 0.090, but improved to 0.037 after 4 months of therapy. The MCG vector reached a value of 0.017 after 5 months of therapy with tafamidis, and then increased slightly after 27 months to a value of 0.027 (<0.052). Data from this case support our previous findings that MCG may be used to monitor treatment response non-invasively. Further research is needed to understand the unexpected changes in the MCG vector that were observed at the beginning of therapy and later in the course. Larger studies will be necessary to determine how these changes in the electromagnetic field of the heart are related to structural changes and how they affect clinical outcomes.

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Magnetokardiographie (MKG): Technischer Fortschritt durch ein Vielkanal-SQUID-System. Klinische Anwendung bei Linkshypertrophie und WPW-Syndrom.

Cited by 3 publications

References 0 publications

Linear analysis of fetal magnetocardiogram recordings in normal pregnancies at various gestational ages

Linear analysis of fetal magnetocardiogram recordings in normal pregnancies at various gestational ages

Application of Magnetocardiography to Screen for Inflammatory Cardiomyopathy and Monitor Treatment Response

Case report: Magnetocardiography as a potential method of therapy monitoring in amyloidosis

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