Magnetoimpedance biosensor prototype for ferrogel detection

Kurlyandskaya, G. V.; Férnández, Eduardo F.; Сафронов, А. П.; Blyakhman, F. A.; Svalov, A. V.; Burgoa, Aizeti; Бекетов, И. В.

doi:10.1016/j.jmmm.2017.06.073

Cited by 18 publications

(7 citation statements)

References 15 publications

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“…Further work will be carried out to test the performance of these FGs in order to create multifunctional devices for applications such as regenerative medicine and magnetic biosensing. Simple prototypes of compact analytical devices working on the principle of the detection of stray fields created by iron oxide magnetic nanoparticles were designed and tested for the case of polyacrylamide-based ferrogels [11,13,33]. For the enhancement of magnetic biosensor sensitivity one can search for magnetic filler, which differ from superparamagnetic iron oxide nanoparticles with the reduced magnetic moment.…”

Section: Resultsmentioning

confidence: 99%

“…Composite materials consisting of magnetic nanoparticles, nanorods, or nanowires embedded into a hydrogel matrix are called ferrogels (FGs) [10,11]. Because they are sensitive to the application of a magnetic field, FGs have attracted special attention for novel applications in regenerative medicine and magnetic biosensing, i.e., areas of research where their ability to mimic basic properties of natural tissues are useful [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Polyacrylamide Ferrogels with Ni Nanowires

Сафронов

Stadler

et al. 2019

Materials

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Nickel magnetic nanowires (NWs) have attracted significant attention due to their unique properties, which are useful for basic studies and technological applications, for example in biomedicine. Their structure and magnetic properties were systematically studied in the recent years. In this work, Ni NWs with high aspect ratios (length/diameter ~250) were fabricated by electrodeposition into commercial anodic aluminum oxide templates. The templates were then etched and the NWs were suspended in water, where their hydrodynamic size was evaluated by dynamic light scattering. The magnetic response of these NWs as a function of an external magnetic field indicates a dominant shape anisotropy with propagation of the vortex domain wall as the main magnetization reversal process. The suspension of Ni NWs was used in the synthesis of two types of polyacrylamide ferrogels (FGs) by free radical polymerization, with weight fractions of Ni NWs in FGs of 0.036% and 0.169%. The FGs were reasonably homogeneous. The magnetic response of these FGs (hysteresis loops) indicated that the NWs are randomly oriented inside the FG, and their magnetic response remains stable after embedding.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polyacrylamide Ferrogels with Ni Nanowires

Сафронов

Stadler

et al. 2019

Materials

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“…These restrictions stem from the difference in the mesh size of the network and the characteristic dimensions of the polysaccharide macromolecules. The mesh size of the PAAm network of the same composition was evaluated in our earlier work . It was found to be 3.9 nm.…”

Section: Discussionmentioning

confidence: 99%

Biomimetic gels with chemical and physical interpenetrating networks

Dobreikina

Shklyar

Сафронов

et al. 2018

Polymer International

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This study aimed to create and to characterize the functional properties of gels with semi-interpenetrating network (semi-IPN) with focus on possible use of these composites in biomedical engineering. Polyacrylamide as a synthetic biocompatible polymer was chosen for the chemical network. The physical network comprised the gel-forming polysaccharides xanthan gum or gellan gum. Gels were synthesized by radical polymerization of acrylamide in aqueous solutions of polysaccharides. Mechanical and electrical properties of gels with 0.2, 0.4, 0.6, 0.8 and 1.0 wt% content of polysaccharide were investigated. It was found that the inclusion of a small amount of xanthan or gellan into the polymeric network of a polyacrylamide gel significantly shifts the gel electrical potential towards the rest potential of living cells and Young's modulus towards the elasticity limits of biological soft tissues like non-activated muscles. From the viewpoint of biomedical applications, the main advantage of the proposed composites is that the semi-IPN structure provides a nonlinear dependence of gel tension on gel deformation, which mimics the elasticity of natural tissues. This feature opens the possibility for the promising use of the proposed gels for musculoskeletal minibioimplants or scaffolds for tissue engineering.

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“…Magnetoimpedance (MI) is the change of total impedance of ferromagnetic-conducting sensitive elements under application of an external magnetic field [ 18 , 19 , 20 ]. Recently, different MI-based bio-sensing systems for micro-sized/nano-sized magnetic particles and single biomarker detection were designed and tested [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

A Multi-Region Magnetoimpedance-Based Bio-Analytical System for Ultrasensitive Simultaneous Determination of Cardiac Biomarkers Myoglobin and C-Reactive Protein

Yang

Wang

Guo

et al. 2018

Sensors

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Cardiac biomarkers (CBs) are substances that appear in the blood when the heart is damaged or stressed. Measurements of the level of CBs can be used in course of diagnostics or monitoring the state of the health of group risk persons. A multi-region bio-analytical system (MRBAS) based on magnetoimpedance (MI) changes was proposed for ultrasensitive simultaneous detection of CBs myoglobin (Mb) and C-reactive protein (CRP). The microfluidic device was designed and developed using standard microfabrication techniques for their usage in different regions, which were pre-modified with specific antibody for specified detection. Mb and CRP antigens labels attached to commercial Dynabeads with selected concentrations were trapped in different detection regions. The MI response of the triple sensitive element was carefully evaluated in initial state and in the presence of biomarkers. The results showed that the MI-based bio-sensing system had high selectivity and sensitivity for detection of CBs. Compared with the control region, ultrasensitive detections of CRP and Mb were accomplished with the detection limits of 1.0 pg/mL and 0.1 pg/mL, respectively. The linear detection range contained low concentration detection area and high concentration detection area, which were 1 pg/mL–10 ng/mL, 10–100 ng/mL for CRP, and 0.1 pg/mL–1 ng/mL, 1 n/mL–80 ng/mL for Mb. The measurement technique presented here provides a new methodology for multi-target biomolecules rapid testing.

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Magnetoimpedance biosensor prototype for ferrogel detection

Cited by 18 publications

References 15 publications

Polyacrylamide Ferrogels with Ni Nanowires

Polyacrylamide Ferrogels with Ni Nanowires

Biomimetic gels with chemical and physical interpenetrating networks

A Multi-Region Magnetoimpedance-Based Bio-Analytical System for Ultrasensitive Simultaneous Determination of Cardiac Biomarkers Myoglobin and C-Reactive Protein

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