Magnetohydrodynamic Thermochemotherapy and MRI of Malignant Tumorigenesis

Abstract

Citric-ferrite sol (CFS) has been synthesized and successfully tested as MRI negative contrast preparation for revealing primary tumors, and also invasions and metastases at the tumor relapses. Magnetohydrodynamic thermochemotherapy (MTC) by Cysplatin (CP), Mitoxantron (MX), Melphalan (MP) combined with CFS, which were carefully monitoring in vivo and quantified by an electronic detector, improved results of cancer treatment. At various stages of oncogenesis, MTC with CFS at a dose of 62 mg Fe/kg combined with chemotherapeutic drugs was performed at +48º C for 30 min. While such MTC, treatment of ~30 mm3 B 16 melanoma tumor by AC magnetic field led to tumor regression in female mice up to 40 %, and an increase of life span up to 300 % was achieved.

Combined Photodynamic Thermochemotherapy of Glial Tumors Controlled by MRI and Electronic Sensor

“…The same was done with 30 rats with glioblastoma 101/8. NaCl buffer (0.9 %, 0.5 ml), 20 µl of gadolinium-based contrast agent Magnevist® [3][4][5][6], DF sol (70-250 nm Fe 3 O 4 -γ-Fe 2 O 3 magnetic particles) were intravenously injected in the tail veins of the rats of groups #1, #2 and #3, respectively. The DF solution had solid content of 5% composed of dextran (69-78%) and magnetic nanoparticles (21-28 %) with magnetization of M s =8.5 kA/m and ζ = +15 mW in 0.5 ml of buffer (pH 6.4).…”

“…In recent experiments on animals, spectroscopy of the 1 H-nuclear magnetic-resonance revealed the tumor development on the 7 th day since inoculation by comparative quantitative analysis of metabolic processes in normal brain and glioma (GC6) of a Vistar rat [2,3]. However, by this time, proliferation of the cells of glioma (CGC6) or glioblastoma (CGB 101/8), neo angiogenesis and infiltration were also observed in the "normal" part of the rat's brain, though the real borders of the tumor cell infiltration were not visible [3][4][5]. The primary goal of this research was development of a method for early (by 3 rd -4 th day since inoculation) revealing with the contrast-enhanced MRI and sensitization of proliferation centers of glial tumors in rats.…”