Magnetoencephalography in Neurosurgery

Mäkelä, Jyrki P.; Forss, Nina; Jääskeläinen, Juha E.; Kirveskari, Erika; Korvenoja, Antti; Paetau, Ritva

doi:10.1227/01.neu.0000232762.63508.11

Cited by 99 publications

(32 citation statements)

References 120 publications

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“…1,2 The results of these studies can direct the surgeon to a confined resectable focus if they are concordant with the clinical semiology and scalp vEEG data.…”

supporting

confidence: 53%

Bilateral Intracranial Electrodes for Lateralizing Intractable Epilepsy

et al. 2010

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“…1,2 The results of these studies can direct the surgeon to a confined resectable focus if they are concordant with the clinical semiology and scalp vEEG data.…”

supporting

confidence: 53%

Bilateral Intracranial Electrodes for Lateralizing Intractable Epilepsy

et al. 2010

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“…Functional brain areas such as primary motor and somatosensory region, Broca's and Wernicke's language areas and their connecting fiber tracts within the CNS are amongst eloquent cortex that can be mapped by functional MRI and DTI [17]. Additionally, MEG is a valid and useful alternative technique for detection of functional brain regions and epileptogenic brain tissue [18,19,20]. …”

Section: Discussionmentioning

confidence: 99%

Frameless Stereotactic Functional Neuronavigation Combined with Intraoperative Magnetic Resonance Imaging as a Strategy in Highly Eloquent Located Tumors Causing Epilepsy

Sommer¹,

Grummich²,

Hamer

et al. 2013

Stereotact Funct Neurosurg

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Background: Intractable epilepsy due to tumors located in highly eloquent brain regions is often considered surgically inaccessible because of a high risk of postoperative neurological deterioration. Intraoperative MRI and functional navigation contribute to overcome this problem. Objectives: To retrospectively investigate the long-term results and impact of functional neuronavigation and 1.5-tesla intraoperative MRI on patients who underwent surgery of tumors associated with epilepsy located close to or within eloquent brain areas. Methods: Nineteen patients (9 female, 10 male, mean age 41.4 ± 13.4 years, 11 low-grade and 8 high-grade glial tumors) were evaluated preoperatively using BOLD imaging, diffusion-tensor imaging tractography and magnetoencephalography. Functional data were implemented into neuronavigation in this multimodal approach. Results: In 14 of 19 patients (74%), complete resection was achieved, and in 5 patients significant tumor volume reduction was accomplished. Eight of 14 (57%) complete resections were achieved only by performing an intraoperative image update. Neurological deterioration was found permanently in 2 patients. After a mean follow-up of 43.8 ± 23.8 months, 15 patients (79%) became seizure free (Engel class Ia). Conclusions: Despite the highly eloquent location of tumors causing intractable epilepsy, our multimodal approach led to complete resection in more than two-thirds of patients with an acceptable neurological morbidity and excellent long-term seizure control.

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“…This issue is not trivial and can become a serious challenge in certain patient populations due to, amongst others, heightened physiological responses, lack of control over movements, and magnetic materials necessary for diagnosis and treatment [4]. In general, the impact of artifacts may be reduced or controlled to some extent through careful preparation and experimental design, and exclusion of the most affected data may facilitate analysis and interpretation.…”

Section: Artifacts and Artifact Removalmentioning

confidence: 99%

“…Typically, healthy adult patients are highly motivated and maintain a constant head position within about 2 mm standard deviation of the measured head positions, in particular when scans are short. Movement related artifacts, however, might increase substantially in certain patient populations and in pediatric measurements [4]. Early approaches aimed at preventing head movement as far as possible with deflatable support cushions, bite-bars, or other constraints.…”

Section: Artifacts and Artifact Removalmentioning

confidence: 99%

Magnetoencephalography: Fundamentals and Established and Emerging Clinical Applications in Radiology

Braeutigam

2013

ISRN Radiology

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Magnetoencephalography is a noninvasive, fast, and patient friendly technique for recording brain activity. It is increasingly available and is regarded as one of the most modern imaging tools available to radiologists. The dominant clinical use of this technology currently centers on two, partly overlapping areas, namely, localizing the regions from which epileptic seizures originate, and identifying regions of normal brain function in patients preparing to undergo brain surgery. As a consequence, many radiologists may not yet be familiar with this technique. This review provides an introduction to magnetoencephalography, discusses relevant analytical techniques, and presents recent developments in established and emerging clinical applications such as pervasive developmental disorders. Although the role of magnetoencephalography in diagnosis, prognosis, and patient treatment is still limited, it is argued that this technology is exquisitely capable of contributing indispensable information about brain dynamics not easily obtained with other modalities. This, it is believed, will make this technology an important clinical tool for a wide range of disorders in the future.

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Magnetoencephalography in Neurosurgery

Abstract: MEG is a mature technique suitable for producing preoperative "road maps" of eloquent cortical areas and for localizing epileptiform activity.

Cited by 99 publications

References 120 publications

Bilateral Intracranial Electrodes for Lateralizing Intractable Epilepsy

Bilateral Intracranial Electrodes for Lateralizing Intractable Epilepsy

Frameless Stereotactic Functional Neuronavigation Combined with Intraoperative Magnetic Resonance Imaging as a Strategy in Highly Eloquent Located Tumors Causing Epilepsy

Magnetoencephalography: Fundamentals and Established and Emerging Clinical Applications in Radiology

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