Magnetoencephalography for Mild Traumatic Brain Injury and Posttraumatic Stress Disorder

Huang, Mingxiong; Lewine, Jeffrey D.; Lee, Roland R.

doi:10.1016/j.nic.2020.02.003

Cited by 7 publications

(5 citation statements)

References 122 publications

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“…In addition, impairment in numerous cognitive domains has been reported in mTBI; these mainly include memory and learning, executive function, processing speed, and attention (4,56). It remains unclear why some of the cognitive domains affected by mTBI while others were spared.…”

Section: Discussionmentioning

confidence: 99%

“…Although deemed "mild", concussed patients remain symptomatic (characterized by physical, emotional, cognitive, and sleep disturbances) for more than 2 weeks in 50% of cases and up to several months in 5-20% of cases after the initial injury (2). Several neuropsychological studies have reported reduced cognitive efficiency in patients with mTBI, especially in processing speed, executive function, connectivity, attention, and memory (3,4). However, to date, the neurobiological mechanism of post-mTBI cognitive impairment remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

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Rich-club reorganization of functional brain networks in acute mild traumatic brain injury with cognitive impairment

Li¹,

Liu²,

Lu³

et al. 2022

Quant Imaging Med Surg

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Background: Mild traumatic brain injury (mTBI) is typically characterized by temporally limited cognitive impairment and regarded as a brain connectome disorder. Recent findings have suggested that a higher level of organization named the "rich-club" may play a central role in enabling the integration of information and efficient communication across different systems of the brain. However, the alterations in rich-club organization and hub topology in mTBI and its relationship with cognitive impairment after mTBI have been scarcely elucidated.Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 88 patients with mTBI and 85 matched healthy controls (HCs). Large-scale functional brain networks were established for each participant. Rich-club organizations and network properties were assessed and analyzed between groups. Finally, we analyzed the correlations between the cognitive performance and changes in rich-club organization and network properties.Results: Both mTBI and HCs groups showed significant rich-club organization. Meanwhile, the rich-club organization was aberrant, with enhanced functional connectivity (FC) among rich-club nodes and peripheral regions in acute mTBI. In addition, significant differences in partial global and local network topological property measures were found between mTBI patients and HCs (P<0.01). In patients with mTBI, changes in rich-club organization and network properties were found to be related to early cognitive impairment after mTBI (P<0.05).Conclusions: Our findings suggest that such patterns of disruption and reorganization will provide the basic functional architecture for cognitive function, which may subsequently be used as an earlier biomarker for cognitive impairment after mTBI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rich-club reorganization of functional brain networks in acute mild traumatic brain injury with cognitive impairment

Li¹,

Liu²,

Lu³

et al. 2022

Quant Imaging Med Surg

View full text Add to dashboard Cite

show abstract

“…Seventy-two scans from 52 healthy subjects (40 female, mean age=29.25 ± 7.43; min/max=21/57) were included in this study. We excluded subjects with: (b) hearing deficits; (a) contraindication to MRI; (c) taking medications acting on the central nervous system, (d) present or past neuropsychiatric disorders, and e) history of head trauma ( Huang et al., 2020 ). The study followed the recommendations of the 1964 Declaration of Helsinki and was approved by the local Ethics Board (Venice Province).…”

Section: Methodsmentioning

confidence: 99%

Auditory driven gamma synchrony is associated with cortical thickness in widespread cortical areas

et al. 2022

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“…Alpha and beta oscillations are thought to be generated in the thalamus [60], [61] and mediated by cortico-thalamic circuits [62], [63], [64] so these results suggest aberrant thalamocortical circuits in mTBI. Abnormalities in the gamma range have also been reported in adults with mTBI [56], [65], [66], [67], although there has been little research on alterations to gamma-mediated connectivity in mTBI. It is possible that decreased gamma coupling may reflect an excitatory-inhibitory (E/I) imbalance due to injury [68].…”

Section: Discussionmentioning

confidence: 99%

The structural, functional, and neurophysiological connectome of mild traumatic brain injury: a DTI, fMRI and MEG multimodal clustering and data fusion study

Zhang,

Solar,

Safar

et al. 2024

Preprint

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The clinical presentation and neurobiology of mild traumatic brain injury (mTBI) - also referred to as concussion - are complex and multifaceted, and interrelationships between neurobiological measures derived from neuroimaging are poorly understood. This study applied machine learning (ML) to multimodal whole-brain functional connectomes from magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI), and structural connectomes from diffusion tensor imaging (DTI) in a test of discriminative accuracy in cases of mTBI. Resting state MEG (amplitude envelope correlations), fMRI (BOLD correlations), and DTI (fractional anisotropy, FA; streamline count, SC) connectome data was acquired in 26 controls without mTBI (all male; 27.6 ± 4.7 years) and 24 participants with mTBI (all male; 29.7 ± 6.7 years) in the acute-subacute phase of injury. ML with data fusion was used to optimally identify modalities and brain features for discriminating individuals with mTBI from those without. Univariate group differences were only found for MEG functional connectivity, while no differences were found for fMRI or DTI. Functional connectivity (fMRI and MEG) showed robust unimodal classification accuracy for mTBI, followed by structural connectivity (DTI), where FA showed marginally better classification performance than SC, but SC outperformed FA in data interpretation and fusion. Perfect, unsupervised separation of participants with and without mTBI was achieved through participant fusion maps featuring all three data modalities. Finally, the MEG-only full feature fusion map showed group differences, and this effect was eliminated upon integrating DTI and fMRI datasets. The markers identified here align well with prior multimodal findings in concussion and highlight modality-specific considerations for their use in understanding network abnormalities of mTBI.

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Magnetoencephalography for Mild Traumatic Brain Injury and Posttraumatic Stress Disorder

Cited by 7 publications

References 122 publications

Rich-club reorganization of functional brain networks in acute mild traumatic brain injury with cognitive impairment

Rich-club reorganization of functional brain networks in acute mild traumatic brain injury with cognitive impairment

Auditory driven gamma synchrony is associated with cortical thickness in widespread cortical areas

The structural, functional, and neurophysiological connectome of mild traumatic brain injury: a DTI, fMRI and MEG multimodal clustering and data fusion study

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