Magnetoencephalographic localization of peritumoral temporal epileptic focus previous surgical resection

Amo, Carlos; Saldaña, Cristóbal; Hidalgo, Mercedes González; Maestú, Fernando; Fernández, Alberto; Arrazola, Juan; Alonso, Tomás Ortiz

doi:10.1016/s1059131102001486

Cited by 10 publications

(4 citation statements)

References 11 publications

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“…Even in those cases where intracranial recordings are strictly necessary (generally when the sources are deep), MEG recordings are useful to determine the area where the electrodes will be implanted. This technique has shown superior performance than EEG (Amo et al 2003, Stefan et al 2004, Ramantani et al 2006.…”

Section: Discussionmentioning

confidence: 99%

“…The main advantage of MEG over EEG is that magnetic fields measured by MEG are much less influenced by the electrical conductivity of the tissues surrounding the cerebral cortex than electrical fields (Shibasaki et al 2007). Both techniques can be considered complementary, and the detection of IEDs improves substantially when used simultaneously (Lin et al 2003, Pataraia et al 2005, Knake et al 2006, although MEG has showed superior performance than EEG when localizing IEDs sources (Amo et al 2003, Stefan et al 2004, Ramantani et al 2006.…”

Section: Introductionmentioning

confidence: 99%

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Influence of metallic artifact filtering on MEG signals for source localization during interictal epileptiform activity

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of metallic artifact filtering on MEG signals for source localization during interictal epileptiform activity

et al. 2016

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“…At seven years of age, her EEG recording indicated high-voltage irregular slow waves intermixed with spikes and polyspikes, which are sometimes observed in patients with focal seizures characterized by impaired awareness [30] that were detected bilaterally in the frontal and central areas (Figure 1).…”

Section: Casementioning

confidence: 99%

Improvement in Impaired Social Cognition but Not Seizures by Everolimus in a Child with Tuberous Sclerosis-Associated Autism through Increased Serum Antioxidant Proteins and Oxidant/Antioxidant Status

Yui

Imataka

Sasaki

et al. 2019

Case Reports in Pediatrics

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We investigated the effect of the mammalian target of rapamycin (mTOR) inhibitor everolimus on tuberous sclerosis complex- (TSC-) associated autistic symptoms and focal seizures with impaired awareness in a female child with TSC. We further evaluated the relationship between improved autistic symptoms and seizures and increased the serum levels of the antioxidant proteins, ceruloplasmin (Cp) and transferrin (Tf), and oxidant-antioxidant status indicated by the oxidant marker oxidized low-density lipoprotein (ox-LDL) and the antioxidant marker total antioxidant power (TAP). Everolimus treatment improved impaired social cognition and autistic behaviors; however, seizure and epileptic activity persisted. Serum Cp and Tf levels gradually increased in response to improved autistic symptoms. Serum TAP levels gradually decreased from baseline to the lowest value at 16 weeks and then increased at 24 weeks, showing a trend toward decreased total score of the Aberrant Behavior Checklist. This study revealed that everolimus treatment improved impaired social cognition with increased serum levels of the copper mediator (Cp) and iron mediator (Tf) via homeostatic control of mTOR activity accompanied by overlap of the oxidant-antioxidant system. Everolimus had no effect on TSC-related epileptiform discharges, and thus, the autistic symptoms and epileptic activity may be two independent end results of a common central nervous system disorder including mTOR hyperactivity. This trial is registered with JMAS-IIA00258.

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“…La localización del foco epiléptico mediante MEG ha sido confirmada con técnicas intraquirúrgicas tal como la estimulación eléctrica cortical 2 , la electrocorticografía (ECoG) 3 y la monitorización invasiva con electrodos subdurales 4 . A pesar de que la capacidad de localización espacial se reduce por los movimientos de la cabeza durante la crisis generalizadas, bajo condiciones especiales se pueden obtener del trazado MEG datos sobre el inicio ictal 5 .…”

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Crisis del lóbulo temporal registrada mediante magnetoencefalografía: caso clínico

Amo

Santiuste

Maestú

et al. 2004

Arq. Neuro-Psiquiatr.

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RESUMEN -La localización del inicio de las crisis es un factor importante para la evaluación prequirúrgica de la epilepsia. En este trabajo se describe la localización del inicio de una crisis registrada mediante magnetoencefalografía (MEG) en un niño de 12 años que presenta crisis parciales complejas farmacorresistentes. La RM muestra una lesión de 20mm de diámetro en el hipocampo izquierdo. EEG de superficie con ondas theta temporales izquierdas. Registro MEG interictal con punta-onda aislada posterior e inferior a la lesión de la RM. Registro MEG ictal con punta-onda (2 Hz). La localización de los dipolos indica el inicio de la crisis en la circunvolución temporal inferior en la misma localización que la actividad interictal MEG. Esta actividad ictal se propaga bilateralmente a áreas frontales. El registro corticográfico intraquirúrgico confirma los resultados de la localización interictal mediante MEG.PALABRAS CLAVE: electrocorticografía, inicio ictal, magnetoencefalografía, propagación. Temporal lobe seizure recorded by magnetoencephalography: case reportABSTRACT -Ictal onset localization is a important factor in presurgical evaluation of epilepsy. This paper describes the localization of a seizure onset recorded by magnetoencephalography (MEG) from a 12-year-old male patient who suffered from complex partial drug-resistant seizures. MRI revealed a 20mm diameter lesion located in left hippocampus. Scalp EEG showed left temporal theta waves. Interictal MEG registrations detected isolated spike-wave activity posterior and inferior to the MRI lesion. Ictal MEG showed continuous spike-wave activity (2 Hz). Dipole localization sited seizure onset in the inferior left temporal gyrus, the same localization of the interictal MEG activity. This ictal activity spreads bilaterally to frontal areas. Intrasurgical electrocorticography recording confirmed interictal MEG results.KEY WORDS: electrocorticography, magnetoencephalography, seizure onset, spreading.La magnetoencefalografía (MEG) en combinación con las imágenes de resonancia magnética (RM) proporciona excelente resolución espacial (milíme-tros) y temporal (milisegundos) en el diagnóstico de la epilepsia, aumentando la capacidad de localización anatómica de la actividad en episodios clíni-cos y subclínicos 1 . La localización del foco epiléptico mediante MEG ha sido confirmada con técnicas intraquirúrgicas tal como la estimulación eléctrica cortical 2 , la electrocorticografía (ECoG) 3 y la monitorización invasiva con electrodos subdurales 4 . A pesar de que la capacidad de localización espacial se reduce por los movimientos de la cabeza durante la crisis generalizadas, bajo condiciones especiales se pueden obtener del trazado MEG datos sobre el inicio ictal 5 . Así la localización basada en datos ictales claramente definidos es considerada como superior a la basada en datos intercríticos 6 y puede aportar información equivalente o superior a la de los registros EEG invasivos 7 . En este artículo se describe la localización anatómica del inicio de una crisis parc...

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Magnetoencephalographic localization of peritumoral temporal epileptic focus previous surgical resection

Abstract: in this particular case, MEG has proven to be a useful presurgical evaluation technique to localize epileptogenic activity, validated by intrasurgical cortical stimulation.

Cited by 10 publications

References 11 publications

Influence of metallic artifact filtering on MEG signals for source localization during interictal epileptiform activity

Influence of metallic artifact filtering on MEG signals for source localization during interictal epileptiform activity

Improvement in Impaired Social Cognition but Not Seizures by Everolimus in a Child with Tuberous Sclerosis-Associated Autism through Increased Serum Antioxidant Proteins and Oxidant/Antioxidant Status

Crisis del lóbulo temporal registrada mediante magnetoencefalografía: caso clínico

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