Magnetoencephalographic analysis of bilaterally synchronous discharges in benign rolandic epilepsy of childhood

Lin, Yung Yang; Chang, Kai Ping; Hsieh, Jen Chuen; Yeh, Ta‐Chuan; Yu, Hsiang‐Yu; Kwan, Shang Yeong; Yen, Der Jen; Yiu, Chun Hing; Hari, Riitta

doi:10.1016/s1059-1311(03)00002-5

Cited by 12 publications

(6 citation statements)

References 28 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Later studies using whole head MEG localised IEDs 10–20 mm anterior and lateral to the hand somatosensory cortex (with concurrent median nerve stimulation) (Lin et al ., ). Dipole analysis of bilateral discharges showed two ECD sources in homotopic motor areas (Lin et al ., ).…”

Section: Magnetoencephalography In the Idiopathic Focal Epilepsies Ofmentioning

confidence: 97%

“…A single ECD accounted for most of the unilateral spikes in a pre‐central location and over 98% of spikes were seen simultaneously on EEG and MEG, suggesting a stable tangential dipole source. For bilateral IED, the temporal difference between bilateral foci was 15–21 ms (Lin et al ., ). The same group correlated the location of IED sources with sensory responses (Lin et al ., ), finding IED sources closer to S2 than S1.…”

Section: Magnetoencephalography In the Idiopathic Focal Epilepsies Ofmentioning

confidence: 97%

See 1 more Smart Citation

Idiopathic focal epilepsies: the “lost tribe”

Pal

Ferrie

Addis

et al. 2016

Epileptic Disorders

View full text Add to dashboard Cite

The term idiopathic focal epilepsies of childhood (IFE) is not formally recognised by the ILAE in its 2010 revision (Berg et al., ), nor are its members and boundaries precisely delineated. The IFEs are amongst the most commonly encountered epilepsy syndromes affecting children. They are fascinating disorders that hold many “treats” for both clinicians and researchers. For example, the IFEs pose many of the most interesting questions central to epileptology: how are functional brain networks involved in the manifestation of epilepsy? What are the shared mechanisms of comorbidity between epilepsy and neurodevelopmental disorders? How do focal EEG discharges impact cognitive functioning? What explains the age‐related expression of these syndromes? Why are EEG discharges and seizures so tightly locked to slow‐wave sleep? In the last few decades, the clinical symptomatology and the respective courses of many IFEs have been described, although they are still not widely appreciated beyond the specialist community. Most neurologists would recognise the core syndromes of IFE to comprise: benign epilepsy of childhood with centro‐temporal spikes or Rolandic epilepsy (BECTS/RE); Panayiotopoulos syndrome; and the idiopathic occipital epilepsies (Gastaut and photosensitive types). The Landau‐Kleffner syndrome and the related (idiopathic) epilepsy with continuous spikes and waves in sleep (CSWS or ESES) are also often included, both as a consequence of the shared morphology of the interictal discharges and their potential evolution from core syndromes, for example, CSWS from BECTS. Atypical benign focal epilepsy of childhood also has shared electro‐clinical features warranting inclusion. In addition, a number of less well‐defined syndromes of IFE have been proposed, including benign childhood seizures with affective symptoms, benign childhood epilepsy with parietal spikes, benign childhood seizures with frontal or midline spikes, and benign focal seizures of adolescence. The term “benign” is often used in connection with the IFEs and is increasingly being challenged. Certainly most of these disorders are not associated with the devastating cognitive and behavioural problems seen with early childhood epileptic encephalopathies, such as West or Dravet syndromes. However, it is clear that specific, and sometimes persistent, neuropsychological deficits in attention, language and literacy accompany many of the IFEs that, when multiplied by the large numbers affected, make up a significant public health problem. Understanding the nature, distribution, evolution, risk and management of these is an important area of current research. A corollary to such questions regarding comorbidities is the role of focal interictal spikes and their enduring impact on cognitive functioning. What explains the paradox that epilepsies characterised by abundant interictal epileptiform abnormalities are often associated with very few clinical seizures? This is an exciting area in both clinical and experimental arenas and will eventually have imp...

show abstract

Section: Magnetoencephalography In the Idiopathic Focal Epilepsies Ofmentioning

confidence: 97%

Section: Magnetoencephalography In the Idiopathic Focal Epilepsies Ofmentioning

confidence: 97%

Idiopathic focal epilepsies: the “lost tribe”

Pal

Ferrie

Addis

et al. 2016

Epileptic Disorders

View full text Add to dashboard Cite

show abstract

“…First, it was applied to MEG and EEG forward data simulated with realistic anatomy and real background MEG/EEG signals. Then, it was applied to an MEG experiment (language lexical judgment test) (Fujimaki et al 1999(Fujimaki et al , 2002 and an EEG experiment (bilateral epilepsy) (Lin et al 2003). From the extensive analyses, it will be shown that the proposed approach can enhance the source localization accuracy considerably, compared to the conventional ones.…”

Section: Introductionmentioning

confidence: 99%

Anatomically constrained dipole adjustment (ANACONDA) for accurate MEG/EEG focal source localizations

Jung

Fujimaki

2005

Phys. Med. Biol.

View full text Add to dashboard Cite

This paper proposes an alternative approach to enhance localization accuracy of MEG and EEG focal sources. The proposed approach assumes anatomically constrained spatio-temporal dipoles, initial positions of which are estimated from local peak positions of distributed sources obtained from a pre-execution of distributed source reconstruction. The positions of the dipoles are then adjusted on the cortical surface using a novel updating scheme named cortical surface scanning. The proposed approach has many advantages over the conventional ones: (1) as the cortical surface scanning algorithm uses spatio-temporal dipoles, it is robust with respect to noise; (2) it requires no a priori information on the numbers and initial locations of the activations; (3) as the locations of dipoles are restricted only on a tessellated cortical surface, it is physiologically more plausible than the conventional ECD model. To verify the proposed approach, it was applied to several realistic MEG/EEG simulations and practical experiments. From the several case studies, it is concluded that the anatomically constrained dipole adjustment (ANACONDA) approach will be a very promising technique to enhance accuracy of focal source localization which is essential in many clinical and neurological applications of MEG and EEG.

show abstract

“…Magnetoencephalography (MEG) can identify and localize benign Rolandic epileptiform discharges (7, 8). Various neuroradiological abnormalities have been reported in children with benign epilepsy of childhood with centrotemporal spikes (BECTS) (4, 6).…”

mentioning

confidence: 99%

Benign epileptiform discharges in Rolandic region with mesial temporal lobe epilepsy: MEG, scalp and intracranial EEG features

RamachandranNair¹,

Ochi²,

Benifla

et al. 2007

Acta Neurol Scand

View full text Add to dashboard Cite

This is the first report on MEG and intracranial video EEG features of BEDs in the Rolandic region, coexisting with hippocampal sclerosis. Persistence of contralateral benign MEG Rolandic dipoles after surgery indicates that BEDs are coincidental in mesial temporal lobe epilepsy. MEG identified Rolandic dipoles, although was unable to localize the deep and focal epileptogenic dipoles from the hippocampal sclerosis.

show abstract

Magnetoencephalographic analysis of bilaterally synchronous discharges in benign rolandic epilepsy of childhood

Cited by 12 publications

References 28 publications

Idiopathic focal epilepsies: the “lost tribe”

Idiopathic focal epilepsies: the “lost tribe”

Anatomically constrained dipole adjustment (ANACONDA) for accurate MEG/EEG focal source localizations

Benign epileptiform discharges in Rolandic region with mesial temporal lobe epilepsy: MEG, scalp and intracranial EEG features

Contact Info

Product

Resources

About