Magnetocardiography is sensitive to differences in inter-atrial conduction in patients with paroxysmal lone atrial fibrillation

Non-invasive detection of conduction pathways to left atrium using magnetocardiography: validation by intra-cardiac electroanatomic mapping

“…19 Magnetocardiography has been accurate in detecting ventricular arrhythmia substrate and localizing cardiac electrical sources, 20,21 and can also be used to analyse the direction of cardiac activation sequences. 22 Preliminary results of MCG mapping of atrial signal propagation during sinus rhythm suggested more variation in atrial activation pattern between AF patients than healthy subjects. 23 Differences were seen mainly in the later parts of the atrial complex and were hypothesized to reflect variation in the propagation of LA activation due to differences in inter-atrial conduction.…”

“…The P-wave morphology in limb leads of the standard ECG recorded during both mappings was used to capture similar atrial activity in each EAM and MCG map pairs. 22 An example of the EAM data and MCG data in the same timescale is shown in Figure 2.…”

Predictive value of unshielded magnetocardiographic mapping to differentiate atrial fibrillation patients from healthy subjects

“…Indeed, although experience is still limited to only few institution, contactless MCG is one of the most promising technology for non‐invasive cardiac electro‐anatomical imaging and accurate localization of arrhythmogenic substrates (Brisinda, Venuti, Sorbo, & Fenici, ; Fenici & Brisinda, ; Fenici, Brisinda, Venuti, & Sorbo, ; Kwong, Leithäuser, Park, & Yu, ). Several studies, all carried out in magnetically shielded rooms, have demonstrated the usefulness of MCG to study AF (Jurkko et al, , ; Kim & Ahn, ; Kim, Kim, Lee, & Ahn, ; Koskinen et al, ; Lehto et al, ; Lim et al, ; Mäntynen et al, ; Nakai et al, ; Sato et al, ; Yamada & Yamaguchi, ; Yamada, Tsukada, Miyashita, Kuga, & Yamaguchi, ; Yoshida et al, ). The reproducibility of automatically measured terminal high‐frequency component of signal averaged atrial magnetic signals was evaluated in PAF patients compared with controls (Koskinen et al, ).…”

“…The reproducibility of automatically measured terminal high‐frequency component of signal averaged atrial magnetic signals was evaluated in PAF patients compared with controls (Koskinen et al, ). MCG provides non‐invasive detection of inter‐atrial conduction pathways (Jurkko et al, ; Mäntynen et al, ) and has shown that susceptibility to PAF is associated with propagation from the right to the LA via margin of FO or multiple pathways (Jurkko et al, , ; Mäntynen et al, ). 3D‐spectral analysis with a 64‐channel MCG was used to preoperatively detect areas of AF dominant frequency (DF; Nakai et al, ; Yoshida et al, ).…”

“…Among different analytic approaches used to evaluate the predictive value of MCG for AF occurrence and recurrence, pseudo‐current reconstruction was reported as sensitive method to non‐invasively differentiate inter‐atrial conduction patterns in normal subjects as well as in patients with PAF (Jurkko et al, ; Koskinen et al, ; Lehto et al, ; Mäntynen et al, ; Sato et al, ). Delayed atrial conduction along in the Bachmann’s bundle (BB), prevalence of inter‐atrial conduction at the fossa ovalis (FO), or multisite inter‐atrial conduction pattern were associated with PAF (Jurkko et al, ).…”