Magnetocardiography in hypertensive and coronary artery disease

Hailer, Birgit; Leeuwen, P. van; Lange, Silke; Chaikovsky, Illya; Grönemeyer, Dietrich

doi:10.1016/j.ics.2007.01.019

Cited by 3 publications

(6 citation statements)

References 10 publications

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“…In clinical applications, magnetocardiography has been mainly used for localization of cardiac arrhythmias 23 , 24 , 25 , 26 , 27 and for early diagnosis of myocardial ischemia. 28 , 29 Furthermore, early reports in literature have described its potential in detecting heart transplant rejection, suggesting a potential role in detecting myocardial inflammation. 30 , 31 …”

mentioning

confidence: 99%

Application of Magnetocardiography to Screen for Inflammatory Cardiomyopathy and Monitor Treatment Response

Brala

Thevathasan

Grahl

et al. 2023

JAHA

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Background Inflammatory cardiomyopathy is one of the most common causes of sudden cardiac death in young adults. Diagnosis of inflammatory cardiomyopathy remains challenging, and better monitoring tools are needed. We present magnetocardiography as a method to diagnose myocardial inflammation and monitor treatment response. Methods and Results A total of 233 patients were enrolled, with a mean age of 45 (±18) years, and 105 (45%) were women. The primary analysis included 209 adult subjects, of whom 66 (32%) were diagnosed with inflammatory cardiomyopathy, 17 (8%) were diagnosed with cardiac amyloidosis, and 35 (17%) were diagnosed with other types of nonischemic cardiomyopathy; 91 (44%) did not have cardiomyopathy. The second analysis included 13 patients with inflammatory cardiomyopathy who underwent immunosuppressive therapy after baseline magnetocardiography measurement. Finally, diagnostic accuracy of magnetocardiography was tested in 3 independent cohorts (total n=23) and 1 patient, who developed vaccine‐related myocarditis. First, we identified a magnetocardiography vector to differentiate between patients with cardiomyopathy versus patients without cardiomyopathy (vector of ≥0.051; sensitivity, 0.59; specificity, 0.95; positive predictive value, 93%; and negative predictive value, 64%). All patients with inflammatory cardiomyopathy, including a patient with mRNA vaccine‐related myocarditis, had a magnetocardiography vector ≥0.051. Second, we evaluated the ability of the magnetocardiography vector to reflect treatment response. We observed a decrease of the pathologic magnetocardiography vector toward normal in all 13 patients who were clinically improving under immunosuppressive therapy. Magnetocardiography detected treatment response as early as day 7, whereas echocardiographic detection of treatment response occurred after 1 month. The magnetocardiography vector decreased from 0.10 at baseline to 0.07 within 7 days ( P =0.010) and to 0.03 within 30 days ( P <0.001). After 30 days, left ventricular ejection fraction improved from 42.2% at baseline to 53.8% ( P <0.001). Conclusions Magnetocardiography has the potential to be used for diagnostic screening and to monitor early treatment response. The method is valuable in inflammatory cardiomyopathy, where there is a major unmet need for early diagnosis and monitoring response to immunosuppressive therapy.

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confidence: 99%

Application of Magnetocardiography to Screen for Inflammatory Cardiomyopathy and Monitor Treatment Response

Brala

Thevathasan

Grahl

et al. 2023

JAHA

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“…The MCG system originally consists of SQUID magnetometers with a single channel. These magnetometers need to be operated in a magnetically shielded room to avoid background noise 79 . Various types of MCG devices have been developed today, such as SQUID magnetocardiography in an unshielded environment, laser‐pumped optical magnetometers, and portable miniaturized induction coils 80,81 .…”

Section: Diagnostic and Predictive Value Of Emf‐based Modalitiesmentioning

confidence: 99%

“…These magnetometers need to be operated in a magnetically shielded room to avoid background noise. 79 Various types of MCG devices have been developed today, such as SQUID magnetocardiography in an unshielded environment, laser-pumped optical magnetometers, and portable miniaturized induction coils. 80,81 During the past 30 years, researchers have conducted extensive studies to evaluate the diagnostic and predictive ability of MCG for coronary artery disease (CAD) and arrhythmic events.…”

Section: Ability Of Mcg To Detect the Magnetic Field Of The Heartmentioning

confidence: 99%

“…The MCG is more sensitive to tangential currents that arise due to the electrical gradients between normal and ischemic heart tissue. It is capable of recording heart vortex currents, which are undetectable by ECG 79,85 . Clinical studies have investigated MCG for the identification of patients with ACS even in the absence of specific findings on ECG and positive marker tests 81,86–91 .…”

Section: Diagnostic and Predictive Value Of Emf‐based Modalitiesmentioning

confidence: 99%

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Electromagnetic field and cardiovascular diseases: A state‐of‐the‐art review of diagnostic, therapeutic, and predictive values

Wang,

Zhao,

Chai

et al. 2023

The FASEB Journal

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Despite encouraging advances in early diagnosis and treatment, cardiovascular diseases (CVDs) remained a leading cause of morbidity and mortality worldwide. Increasing evidence has shown that the electromagnetic field (EMF) influences many biological processes, which has attracted much attention for its potential therapeutic and diagnostic modalities in multiple diseases, such as musculoskeletal disorders and neurodegenerative diseases. Nonionizing EMF has been studied as a therapeutic or diagnostic tool in CVDs. In this review, we summarize the current literature ranging from in vitro to clinical studies focusing on the therapeutic potential (external EMF) and diagnostic potential (internal EMF generated from the heart) of EMF in CVDs. First, we provided an overview of the therapeutic potential of EMF and associated mechanisms in the context of CVDs, including cardiac arrhythmia, myocardial ischemia, atherosclerosis, and hypertension. Furthermore, we investigated the diagnostic and predictive value of magnetocardiography in CVDs. Finally, we discussed the critical steps necessary to translate this promising approach into clinical practice.

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“…Magnetocardiography (MCG) is a non-invasive diagnostic tool used to investigate the activity of the heart. Researchers have long considered its clinical applications, and many investigations have been conducted for cardiac diseases, such as ischemic heart disease (Park et al 2005, Hailer et al 2003, hypertensive cardiovascular disease (Hailer et al 2007, Yamada et al 2003, myocardial infarction (Korhonen et al 2003) and cardiac arrhythmias (Fenici and Melillo 1993). It was clinically proven that MCG can provide unique access to the electrophysiological processes of the heart.…”

Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of signal integrity for magnetocardiography

Zhang

Wang

et al. 2009

Phys. Med. Biol.

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Magnetocardiography (MCG) is a non-invasive diagnostic tool used to investigate the activity of the heart. For applications in an unshielded environment, in order to extract the very weak signal of interest from the much higher background noise, dedicated hardware configuration and sophisticated signal processing techniques have been developed during the last decades. Being powerful in noise rejection, the signal processing may introduce signal distortions, if not properly designed and applied. However, there is a lack of an effective tool to quantitatively evaluate the signal integrity for MCG at present. In this paper, we have introduced a very simple method by using a small coil driven by a human ECG signal to generate a simulated MCG signal. Three key performance indexes were proposed, which are correlation in time domain, relative heights of different peaks and correlation in frequency domain, to evaluate the MCG system performance quantitatively. This evaluation method was applied to a synthetic gradiometer consisting of a second-order axial gradiometer and three orthogonal reference magnetometers. The evaluation turned out to be very effective in optimizing the parameters for signal processing. In addition, the method can serve as a useful tool for hardware improvement.

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Magnetocardiography in hypertensive and coronary artery disease

Cited by 3 publications

References 10 publications

Application of Magnetocardiography to Screen for Inflammatory Cardiomyopathy and Monitor Treatment Response

Application of Magnetocardiography to Screen for Inflammatory Cardiomyopathy and Monitor Treatment Response

Electromagnetic field and cardiovascular diseases: A state‐of‐the‐art review of diagnostic, therapeutic, and predictive values

Quantitative evaluation of signal integrity for magnetocardiography

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