Magneto-Plasmonic Nanocapsules for Multimodal-Imaging and Magnetically Guided Combination Cancer Therapy

Abstract

Integrating multiple discrete functionalities into hollow-mesoporous architecture with distinctive electronic/magnetic property is of particular interest for building multifunctional drug carriers with complementary theranostic modalities. In this article, the "non-contact" incorporation of gold nanorod (GNR) into porous magnetic nanoshell is achieved via yolk−shell structure, which was intrinsically different from previous direct chemical or heterogeneous conjugation of the two components. The highly preserved plasmonic feature of GNRs enabled photothermal induced photoacoustic imaging and hyperthermia capabilities. The magnetic shell consisted of stacked primary iron oxide nanocrystals yields strong superparamagnetic response with excellent permeability for magnetically targeted drug delivery. Interestingly, the special coordination between doxorubicin and iron species enabled pH/local heating dual-responsive drug release with minor leakage at neutral pH. Under the guidance of magnetic resonance/photoacoustic dual-modal imaging and magnetically tumor targeting using the nanoagents, the photothermal-chemo synergistic therapy was conducted via near-infrared laser for highly efficient tumor eradication.

Next-generation superparamagnetic iron oxide nanoparticles for cancer theranostics

“…Photothermal therapy (PTT) uses near infrared irradiation (NIR) laser irradiation to generate heat for tumor ablation [46]. Compared to conventional therapeutic approaches, PTT can provide more precise spatial-temporal selectivity with little collateral damage of adjacent normal tissues [47].…”

Janus Magnetic‐Plasmonic Nanoparticles for Magnetically Guided and Thermally Activated Cancer Therapy

“…Besides, magnetic nanoparticles were recently found to be valuable PTT agents in the NIR, on top of their intrinsic heating potential for MHT, [ 16 ] which also allowed to combine both modalities in magneto‐photothermal tumor treatment. [ 17 ] However, the association of magnetic guiding and PTT has thus far attracted less attention and has been only scarcely investigated in magneto‐plasmonic nanohybrids, [ 14a,18 ] with just a few works reporting in vivo results (see Table S2, Supporting Information). Among them, Huang et al [ 18a ] recently showed efficient tumor eradication using magnetic homing of gold/iron oxide nanocapsules associated with 1 W cm −2 PTT ablation and anticancer drug delivery.…”

“…[ 17 ] However, the association of magnetic guiding and PTT has thus far attracted less attention and has been only scarcely investigated in magneto‐plasmonic nanohybrids, [ 14a,18 ] with just a few works reporting in vivo results (see Table S2, Supporting Information). Among them, Huang et al [ 18a ] recently showed efficient tumor eradication using magnetic homing of gold/iron oxide nanocapsules associated with 1 W cm −2 PTT ablation and anticancer drug delivery. Furthermore, the combination of magnetically guided targeting and subsequent 1.3 W cm −2 PTT irradiation of gold and iron multishells resulted in high therapeutic efficacy.…”

“…[ 14a ] In both studies, the treatments were complemented with the locally delivery of drugs. Yang et al [ 18c ] combined dual MRI/photoacoustic (PA) imaging with magnetically guided high‐dose PTT (2 W cm −2 ) employing magnetic polymer‐modified gold nanorods in a 10 d period treatment.…”

Optical Anisotropicity of Core‐Shell or Yolk‐Shell‐typed Ag@Fe3O4 Nanochains

“…For example, Okada et al, reported that YOSH particles were hollow silica particles containing a movable magnetic silica core were prepared to form pearl chains, showing doublet magnetic silica core in the shell compartment of the quasi-pearl chain structure under the external magnetic field. 11 However, research has been limited to use plasmonic and magnetic mingled structures such as COSH or YOSH nanostructure due to complex synthesis mechanism. [7][8][9][10] Recently, the non-contact incorporation of gold nanorod into porous magnetic nanoshell is achieved via yolk-shell structure to conduct photothermal induced photoacoustic imaging and hyperthermia capabilities with excellent permeability for magnetically targeted drug delivery.…”