Magneto‐Plasmonic Janus Vesicles for Magnetic Field‐Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors

Liu, Yijing; Yang, Xiangyu; Huang, Zhiqi; Huang, Peng; Zhang, Yang; Deng, Lin; Wang, Zhantong; Zhou, Zijian; Liu, Yi; Kalish, Heather; Khachab, Niveen M.; Chen, Xiaoyuan; Nie, Zhihong

doi:10.1002/anie.201608338

Cited by 111 publications

(118 citation statements)

References 45 publications

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“…To prepare multifunctional nanomaterials for the delivery of dual cargos, one strategy is hybrid nanoparticle, including metal–metal and metal–metal oxide nanocomposites which guarantee complex functionality. The hybrid nanoparticles can be used to realize efficient applications, for example, multitype drug delivery, implementation of orthogonal imaging strategies for enhanced imaging resolution, immunotherapy, and cancer therapy . Among them, multitype drug delivery strategy for single disease target is regarded as promising approach to treat multidrug resistant cells which commonly occur by mutation …”

Section: Methodsmentioning

confidence: 99%

Development of Dual‐Pore Coexisting Branched Silica Nanoparticles for Efficient Gene–Chemo Cancer Therapy

Lee

Kang

Ahn

et al. 2017

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Various strategies for combination therapy to overcome current limitations in cancer therapy have been actively investigated. Among them, simultaneous delivery of multiple drugs is a subject of high interest due to anticipated synergistic effect, but there have been difficulties in designing and developing effective nanomaterials for this purpose. In this work, dual-pore coexisting hybrid porous silica nanoparticles are developed through Volmer-Weber growth pathway for efficient co-delivery of gene and anticancer drug. Based on the different pore sizes (2-3 and 40-45 nm) and surface modifications of the core and branch domains, loading and controlled release of gene and drug are achieved by appropriate strategies for each environment. With excellent loading capacity and low cytotoxicity of the present platform, the combinational cancer therapy is successfully demonstrated against human cervical cancer cell line. Through a series of quantitative analyses, the excellent gene-chemo combinational therapeutic efficiency is successfully demonstrated. It is expected that the present nanoparticle will be applicable to various biomedical fields that require co-delivery of small molecule and nucleic acid.

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Section: Methodsmentioning

confidence: 99%

Development of Dual‐Pore Coexisting Branched Silica Nanoparticles for Efficient Gene–Chemo Cancer Therapy

Lee

Kang

Ahn

et al. 2017

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“…That is, low grafting density is not favorable for fusion of AuNP from the middle of the chain due to the steric effect because new NPs prefer to integrate from the end of chain (Figure E). Nie and co‐workers also demonstrated the versatility of this strategy to coassemble three constituent blocks, including AuNP@PSPEO, PS‐ b ‐PAA, and hydrophobic Fe 3 O 4 , into Janus vesicular structure (Figure F) . The incorporation of both plasmonic and magnetic components make the Janus vesicle (half Au and half Fe 3 O 4 ) an ideal platform for in vivo bimodal imaging of PAI and magnetic resonance imaging (MRI).…”

Section: Construction Of Plasmonic Assemblies Through Self‐assembly Omentioning

confidence: 97%

Section: Construction Of Plasmonic Assemblies Through Self‐assembly Omentioning

confidence: 99%

“…Very recently, Duan, Chen and co‐workers reported a PNC‐Polymer hybrid vesicle with a bilayer membrane wall using amphiphilic Au@Fe 3 O 4 JNPs . The Au@Fe 3 O 4 JNPs integrated magnetic and plasmonic properties into a single NP and therefore affords the dual PA and MR imagings in vivo applications, which together with SERS enhancement effect and interior cavity make them promising contrast agents, detection probes, and delivery vehicle to realize multifunctional diagnosis and therapeutic applications in a single nanoplatform …”

Section: Construction Of Plasmonic Assemblies Through Self‐assembly Omentioning

confidence: 99%

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Self‐Assembly of Polymer‐Coated Plasmonic Nanocrystals: From Synthetic Approaches to Practical Applications

Zhou

Chen

et al. 2018

Macromol. Rapid Commun.

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Such coupling can induce significant red-shifts in LSPR spectra and create greatly enhanced electromagnetic fields, both of which endow plasmonic assemblies with dramatically different optical properties compared to single PNC counterparts. [43,[48][49][50] Small molecular surfactants (i.e., hexadecyltrimethylammonium bromide-CTAB), [51] silica, [52][53][54] biomacromolecules (e.g., DNA), [55][56][57][58][59] and synthetic polymers are the most commonly used surface coatings for PNCs, [60,61] imparting surface functionalities to direct their selfassembly. Small molecular surfactants are able to provide decent stability in dielectric environments (e.g., aqueous solution), although their relatively small sizes makes it difficult to control interparticle spacing or intraparticle gap sizes. Both silica and DNA have been used as "spacers" for the SERS and fluorescence signal enhancement, but inherent size limits hold back their further extended uses. For example, the silica coating is difficult for building a gap of smaller than 10 nm, [52,62] while DNA has not demonstrated its utility in realizing a relatively large nanogap (i.e., >2 nm). [57,59] Consequently, such size-tuning limitation makes them challenging to offer sufficient structural flexibility to tailor the LSPR, which is crucial for obtaining an optimal enhancement effect (e.g., fluorescence enhancement). [52,63,64] Moreover, the coassembly of DNA and PNC is primarily based on the base-pairing recognition, [58,65,66] which is too specific for the extensive uses.In contrast, there are a number of benefits in conjugating polymers with PNCs to direct their self-assembly: i) The conformation transformation of polymer chains provides the driving force for self-assembly. [43,45,48,[67][68][69] For example, the amphiphilic single-component or mixed polymer brushes anchored onto the PNCs can afford amphiphilicity-driven self-assembly to produce a library of assemblies including core-shell structure, Janus nanoparticles (JNPs), nanocluster, nanochain, lamellae, and vesicle. ii) The polymeric corona protects the PNC core and stabilizes the assemblies in dispersion media. [68,70,71] iii) By using stimuli-responsive polymer coatings, the formed assemblies can readily undergo structural changes in response to the external triggers. [15,[72][73][74][75][76] Moreover, the strength of interactions between polymer/PNC hybrid materials and external stimuli can be adjusted by varying the structures of the polymer coating, such as molecular weight (M w ) of the polymer. The large-sized polymer coating leads to more significant multivalent effects compared to small molecular ligands. iv) Also important is Plasmonic Nanocrystals Self-assembly of plasmonic nanocrystals (PNCs) and polymers provides access to a variety of functionalized metallic-polymer building blocks and higher-order hybrid plasmonic assemblies, and thus is of considerable fundamental and practical interest. The hybrid assemblies often not only inherit individual characteristics of polymers and PNCs but also exhi...

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“…For example, sulfonate‐based saline [GdO] + [ICG] − (ICG, indocyanine green) nanoparticles were proposed with ICG (a FDA‐approved cyanine dye) as PA‐active component and GdO (a source of paramagnetic gadolinium for T 1 MR imaging but with some delayed toxicity concerns) as MRI‐active component . In these studies, each component serves its particular imaging function and there are only very few reports on the potential amplification of imaging performance due to the influence between the two active components in PA‐MRI bimodal contrast agents …”

Section: Introductionmentioning

confidence: 99%

Photoacoustic and Magnetic Resonance Imaging Bimodal Contrast Agent Displaying Amplified Photoacoustic Signal

Duan

Mao

et al. 2018

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Progress in photoacoustic (PA) and magnetic resonance imaging (MRI) bimodal contrast agents has been achieved mainly by utilizing the imaging capability of single or multiple components and consequently realizing the desired application for both imaging modalities. However, the mechanism of the mutual influence between components within a single nanoformulation, which is the key to developing high‐performance multimodal contrast agents, has yet to be fully understood. Herein, by integrating conjugated polymers (CPs) with iron oxide (IO) nanoparticles using an amphiphilic polymer, a bimodal contrast agent named CP‐IO is developed, displaying 45% amplified PA signal intensity as compared to bare CP nanoparticle, while the performance of MRI is not affected. Further experimental and theoretical simulation results reveal that the addition of IO nanoparticles in CP‐IO nanocomposites contributes to this PA signal amplification through a synergistic effect of additional heat generation and faster heat dissipation. Besides, the feasibility of CP‐IO nanocomposites acting as PA‐MRI bimodal contrast agents is validated through in vivo tumor imaging using mice models. From this study, it is demonstrated that a delicately designed structural arrangement of various components in a contrast agent could potentially lead to a superior performance in the imaging capability.

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Magneto‐Plasmonic Janus Vesicles for Magnetic Field‐Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors

Cited by 111 publications

References 45 publications

Development of Dual‐Pore Coexisting Branched Silica Nanoparticles for Efficient Gene–Chemo Cancer Therapy

Development of Dual‐Pore Coexisting Branched Silica Nanoparticles for Efficient Gene–Chemo Cancer Therapy

Self‐Assembly of Polymer‐Coated Plasmonic Nanocrystals: From Synthetic Approaches to Practical Applications

Photoacoustic and Magnetic Resonance Imaging Bimodal Contrast Agent Displaying Amplified Photoacoustic Signal

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