Magneto‐Mechano‐Electric Cascade Stimulation System Accelerates Wound Healing Constructed by Biodegradable Magnetoelectric Nanofibers

Abstract

Reconstructing the intricate biophysical microenvironment to provide multiple biologically beneficial stimulation is deemed a promising therapeutic strategy. However, developing multi‐biophysical stimuli with wireless integration and accurate management remains a formidable challenge. Herein, a novel design of a magneto‐mechano‐electric (MME) cascade stimulation system based on aligned magnetoelectric nanofibrous membranes (PLLA/CFO) is reported. Simply regulating the loading amount of CFO nanoparticles endows the PLLA/CFO membranes with excellent magnetism, enhanced crystallization, and resultant piezoelectric responsiveness, thus providing built‐in topographical guidance and nanoscale magnetic field as well as manageably remote stimulation. Specifically, assisted by an external magnetic field (EMF), the magnetic response in PLLA/CFO can be amplified to offer an apparent deformation, which then induces the output of mechanical and electrical cues. Benefiting from the slow degradability of PLLA and continuous EMF triggering, such a performance can be well modulated to match the practical wound healing process, demonstrated by the repair of a rat full‐thickness skin defect. More importantly, this work offers a new strategy to reconstruct the complex biophysical microenvironment in a wireless remote manner.

Magneto-responsive biocomposites in wound healing: from characteristics to functions

“…39,40 Researchers have confirmed that magneto-responsive biocomposites can effectively promote skin wound healing through mechanisms such as modulating cell behavior, magnetic hyperthermia sterilization, and controlled drug release. [41][42][43][44] However, a comprehensive review of magneto-responsive biocomposites as wound dressings has yet to be reported.…”

“…This work presents a novel strategy for reconstructing complex biophysical microenvironments remotely. 42 Apart from the magneto-mechano-electric effect, the increase in conductivity due to magnetic anisotropy can also be utilized to enhance intercellular electrical signal transmission. Inspired by the highly ordered hierarchical structure of natural soft tissues, Li et al introduced ordered magneto-electric nanosheets (MPG) into gelatin-oxidized dextran (Gel-ODex) hydrogels, imparting anisotropy to the hydrogel (Fig.…”

“…5 (A) Schematic illustration of the design of an MME cascade stimulation system constructed by the coupled PLLA/CFO nanofibrous membrane and the mechanism of the system for promoting wound healing. 42 Copyright 2023, Wiley. (B) Schematics of the preparation of the anisotropic GOH-MPG conductive hydrogel and its medical application; effect of rGO, PDA and MPG on the conductive performance of the hydrogels.…”

Wearable Magnetoelectric Stimulation for Chronic Wound Healing by Electrospun CoFe2O4@CTAB/PVDF Dressings

“…19 To date, magneto-electric coupling stimulation has rarely been reported to enhance the endogenous electric field in promoting skin wound healing. 20 This may be attributed to several challenges. On the one hand, traditional magnetic field generation devices rely on large magnets (DC magnetic field) or high-power Helmholtz coils (AC magnetic field), lacking tissue safety and wearability due to high intensity or frequency.…”

“…To date, magneto-electric coupling stimulation has rarely been reported to enhance the endogenous electric field in promoting skin wound healing . This may be attributed to several challenges.…”